A5006550282- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Visual perception and processing mechanisms
- Ocular and Laser Science Research
- Orthopedic Surgery and Rehabilitation
- Glaucoma and retinal disorders
- Neural dynamics and brain function
- Tendon Structure and Treatment
- Color Science and Applications
- Neuroscience and Neuropharmacology Research
- Systemic Lupus Erythematosus Research
- Musculoskeletal synovial abnormalities and treatments
- Neuroscience and Neural Engineering
- Retinal Diseases and Treatments
- Musculoskeletal Disorders and Rehabilitation
- Impact of Light on Environment and Health
- Foot and Ankle Surgery
- Gout, Hyperuricemia, Uric Acid
- Shoulder Injury and Treatment
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Corneal surgery and disorders
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Hip disorders and treatments
Roche (Canada)
2024
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2023
National Institutes of Health
2023
Arthritis and Rheumatism Associates
2013-2021
Center for Rheumatology
2020-2021
Georgetown University
2018-2020
University of Louisville
2006-2017
Francis Marion University
2013
MedStar Washington Hospital Center
2005-2007
University of Louisville Hospital
2007
Abstract Objective The reported frequency of scleroderma M01‐R renal crisis (SRC) in diffuse systemic sclerosis (SSc; scleroderma) is 15–20%. Early use angiotensin‐converting enzyme (ACE) inhibitors has markedly improved outcome. present analysis reexamines the prognostic factors for and outcome SRC a prospective cohort patients with early SSc. Methods We retrospectively evaluated SSc who participated High‐Dose Versus Low‐Dose D‐Penicillamine Diffuse trial. Patients cutaneous were enrolled...
We derived the cone fundamentals for X-chromosome-linked anomalous trichromats wavelength range of 400–700 nm. Pigment templates were constructed from normal after correction ocular media absorption. The resultant retinal-level sensitivities had small irregularities in short-wavelength region that smoothed. pigment templates, expressed as quantal sensitivities, then shifted on a frequency abscissa to solve λmax pigments needed predict average anomaloscope matching data. found protanomalous...
Purpose.: The Pro23His (P23H) rhodopsin (RHO) mutation underlies the most common form of human autosomal dominant retinitis pigmentosa (adRP). objective this investigation was to establish a transgenic miniature swine model RP using P23H RHO gene. Methods.: Somatic cell nuclear transfer (SCNT) used create pigs that expressed mutation. From these experiments, six founders were identified whose retinal function studied with full-field electroretinography (ffERG) from 3 months through 2 years....
Gout typically affects the peripheral joints of appendicular skeleton and rarely involves axial joints. The literature on gout is limited to case reports series. This preliminary study was conducted identify frequency characteristics gout.Six hundred thirty medical records with ICD codes 274.0, 274.82, 274.9 for were reviewed. Ninety-two patients had clinical or crystal-proven gout, which 64 prior computed tomography (CT) images spine performed various reasons. These CT reviewed features...
Background: Ultrasound is increasingly recognized as a valuable addition to medical school curriculum. Purpose: In this study, we tested the ability of rising second year students learn and conduct an ultrasound examination vertical liver span at point care. Methods: Six patients from GI clinic volunteered have their size measured. Ten were trained measure with ultrasound. Four physicians recruited standard methods. Student physician measurements compared each other reference measurement for...
Microspectrophotometry studies show that zebrafish ( Danio rerio ) possess four cone photopigments. The purpose of this study was to determine the contributions photopic increment threshold spectral-sensitivity function. Electroretinogram (ERG) b -wave responses monochromatic lights presented on a broadband or chromatic background were obtained. It found under condition, function showed several peaks narrower in sensitivity compared spectra. modeled with L − M and S opponent interactions...
The transcription factor Nr2e3 is an essential component for development and specification of rod cone photoreceptors; however, the mechanism through which it acts not well understood. In this study, we use rd7/rd7 mice that harbor a mutation in , to serve as model human retinal disease Enhanced S Cone Syndrome. Our studies reveal NR2E3 expressed late progenitors differentiating photoreceptors developing retina localized cell bodies mature rods cones. particular, demonstrate abnormal...
purpose. Subretinal prosthetics are designed to electrically stimulate second-order cells, replacing dysfunctional photoreceptors in diseases such as retinitis pigmentosa (RP). For functional vision occur, this signal must also reach central visual structures. In the current study, a subretinally implanted prosthetic was evaluated Royal College of Surgeons (RCS) rat model RP, determine its capacity activate retinotectal pathway. methods. Prosthetic implants were placed RCS and wild-type (WT)...
PURPOSE. Transgenic pigs carrying a mutant human rhodopsin transgene have been developed as large animal model of retinitis pigmentosa (RP). This displays some key features RP, but the time course disease progression makes this costly, consuming, and difficult to study because size animals at end-stage disease. Here, authors evaluate an iodoacetic acid (IAA) photoreceptor degeneration in pig alternative that shares transgenic RP. METHODS. IAA blocks glycolysis, thereby inhibiting function....
Human and swine retinas have morphological functional similarities. In the absence of primate models, is an attractive model to study retinal function disease, with its cone-rich visual streak, our ability manipulate their genome, differences in susceptibility rod cone photoreceptors disease. We characterized normal development subsequent decline a P23H rhodopsin transgenic (TgP23H) miniswine autosomal dominant RP.Semen from TgP23H 53-1 inseminated domestic produced Wt hybrid littermates....
To determine the reliability and validity of an objective structured clinical examination (OSCE) for musculoskeletal ultrasound (MSUS).A 9-station OSCE was administered to 35 rheumatology fellows trained in MSUS 3 expert faculty (controls). Participants were unaware joint health (5 diseased/4 healthy). Faculty assessors (n = 9) graded image quality with predefined checklists a 0-5 global rating, blinded who performed study. Interrater reliability, correlation between written multiple choice...
We characterize the progression of retinopathy in Filial 1 (F1) progeny a transgenic (Tg) founder miniswine exhibiting severe Pro23His (P23H) retinopathy.The F1 TgP23H were created by crossing 53-1 with wild type (WT) inbred miniature swine. Scotopic (rod-driven) and photopic (cone-driven) retinal functions evaluated WT littermates using full field electroretinograms (ffERGs) at 1, 2, 3, 6, 9, 12, 18 months age, as well Tg 6 years age. Miniswine euthanized their retinas processed for...
Abstract The vertebrate retina processes visual information in parallel neural pathways known as the ON and OFF pathways. These encode increments decrements of light independently excitatory responses. We examined photopic spectral response mechanisms goldfish by measuring sensitivity optic nerve responses to onset termination stimuli various wavelengths. Using adapting backgrounds, we found that have different sensitivities. weighting cone inputs was estimated an algebraic summation model....
Abstract Psychophysical studies have documented that many observers show lower thresholds for rapid-off than rapid-on sawtooth luminance modulation. This finding, together with physiological findings from chromatically opponent ganglion cells of the macaque monkey, prompted a search similar bias in psychophysical detection chromatic increments and decrements light. Using pedestal conjunction background to favor by mechanisms, we measured spectral sensitivity stimuli presented spatially...
Abstract Previous studies report that background luminance flicker, which is asynchronous with signal averaging, reduces the amplitude and increases latency of pattern-onset visual evoked potential (VEP). This effect has been attributed to saturation magnocellular (m-) pathway by flicker stimulus. In current study, we evaluate this hypothesis further characterize effect. We found had similar effects on pattern-reversal VEP, suggesting reversal onset responses have generators. Chromatic...
Abstract Visual responses of goldfish to rotating square-wave gratings were recorded before and after intraocular injection 2-amino-4-phosphonobutyric acid (APB). High doses APB reduced the rate optokinetic nystagmus (OKN) a relatively high spatial frequency grating moving at temporal frequency. Responses low not altered, nor higher when it rotated slowly. The effects transient lasted no longer than 3 d. We conclude that reduces OKN spatiotemporal frequencies in goldfish.