Akash Mukherjee
A5024842091- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Hematopoietic Stem Cell Transplantation
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Brain Metastases and Treatment
- Neutropenia and Cancer Infections
- Cancer Diagnosis and Treatment
- Polyomavirus and related diseases
- Acute Myeloid Leukemia Research
- Gut microbiota and health
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Anesthesia and Pain Management
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Platelet Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
Indian Institute of Technology Delhi
2023-2025
University of Arkansas for Medical Sciences
2021-2024
Methodist Hospital
2016-2024
The University of Texas MD Anderson Cancer Center
2018-2024
University of Arkansas Medical Center
2024
Oncology Hematology Care
2024
Winthrop Rockefeller Foundation
2023
Kempegowda Institute of Medical Sciences
2021
Cornell University
2017-2018
Weill Cornell Medicine
2017-2018
Sustainable Development Goal 3.4 (SDG-3.4) aims to reduce non-communicable disease (NCD) mortality by one-third 2030, compared 2015 levels. First, we examined whether the National Clean Air Program (NCAP) is sufficient allow India achieve this target. Subsequently, integrated GAINS-simulated sector-specific PM2.5 concentrations across three pathways─business-as-usual (BAU), advanced control technology (ACT), and sustainable development scenario (SDS)─with Global Burden of Disease framework...
On the basis of results ZUMA-3 trial, brexucabtagene autoleucel (brexu-cel), a CD19-directed chimeric antigen receptor T-cell therapy, gained US Food and Drug Administration approval in October 2021 for adults with relapsed/refractory (R/R) B-cell ALL (B-ALL). We report outcomes patients treated brexu-cel as standard therapy.
Highlights•CKS1B gain(1q+)/CDKN2C deletion (1p–) has shorter progression-free survival (PFS) despite propensity score matching.•PFS of 3 copies 1q+ was longer than ≥4 and approached significance•1q+/1p– suggestive being an independent risk factor for survival.ABSTRACTThe gain/amplification CKS1B gene at chromosome region 1q21 (1q+) is one the most common genetic aberrations in multiple myeloma (MM). Amplification frequently associated with CDKN2C 1p32 (1p–), which also inferior outcomes.In...
The effect of prior inotuzumab ozogamicin (InO) treatment on brexucabtagene autoleucel (brexu-cel) outcomes remains unclear in adults with acute lymphoblastic leukemia (ALL). We conducted a retrospective multicenter analysis 189 patients relapsed/refractory ALL treated brexu-cel. Over half the received InO before brexu-cel (InO exposed). InO-exposed were more heavily pretreated (P = .02) and frequently had active marrow disease apheresis .03). Response rate toxicity profile after comparable...
Acute gastrointestinal intestinal GVHD (aGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation, and the microbiota known to impact on its severity. However, an association between treatment response aGI-GVHD has not been well-studied. In cohort patients with (n=37), we found that non-response standard therapy corticosteroids was associated prior carbapenem antibiotics loss
Patients with multiple myeloma t(11;14) have been considered to standard-risk disease. However, several recent reports shown contradictory results. We identified 95 patients on FISH studies, who underwent upfront autologous hematopoietic stem cell transplant (auto-HCT) at our center. compared their outcome a group of had diploid cytogenetics by both conventional (CC) and (n = 287).To reduce the bias between groups, we performed 1:1 propensity score matching technique for analysis. A total...
Importance. Laryngeal cancer infrequently results in distant metastases, but metastasis to skeletal muscle is extremely uncommon. Observations. A 55-year-old male presenting with progressive dyspnea and hoarseness was found have Stage IVA T4aN2cM0 laryngeal eventually underwent total laryngectomy. Before the patient could be started on adjuvant chemoradiation, developed masses both thighs. Biopsy revealed metastatic squamous cell carcinoma consistent primary cancer. He offered palliative...
An important assessment of the quality health care is patient satisfaction. However, only few studies are available which look into this aspect. The primary objective study was to compare satisfaction between regional anaesthesia (RA) and general (GA) in patients undergoing upper limb surgeries. length hospital stay duration analgesia two techniques were secondary objectives.This cross-sectional carried out a tertiary teaching hospital. Patients aged 18 years 60 years, physical status...
sufficient" (either insufficient or deficient) were 47% higher at 100 days, 30% 6 mo., 69% lower 1 y, and 81% 2 y (linear trend p = .023)and estimated odds of sufficiency 39% 21% 41-42% .087)(Figure1).A review medical records showed that proportion patients receiving supplemental vitamin D 7.5%, 10%, 19%, 42% pre-HCT, +100 post-HCT time-points, respectively.Conclusions: We show a high prevalence rate insufficiency deficiency prior to early after HCT.We also found the improved over À...
We aimed to study the risks of graft-versus-host disease (GVHD), non-relapse mortality (NRM) and survival outcomes allogeneic stem cell transplantation (alloSCT) in patients with chronic lymphocytic leukemia (n = 17), Richter's syndrome 14), or lymphoma 18) after small molecule inhibitors (SMIs). Patients had a median 4 prior therapies, including ibrutinib 46; 94%), venetoclax 19; 39%), idelalisib 6; 12%). Twenty-one (43%) >1 SMI. P53 mutation was detected 58% patients. The 3-year overall...
General anesthesia and neuraxial blockade have their own advantages disadvantages over each other when used for hip surgery. Single shot lumbar plexus block can be the choice of anesthetic technique postrenal transplant, immunocompromised, postspinal surgery patient to undergo dynamic screw