A5089779635- Acute Lymphoblastic Leukemia research
- Virus-based gene therapy research
- CAR-T cell therapy research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Eastern European Communism and Reforms
- Soviet and Russian History
- Historical Geopolitical and Social Dynamics
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Animal Virus Infections Studies
- Cervical and Thoracic Myelopathy
- Animal Disease Management and Epidemiology
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- German History and Society
- Bacteriophages and microbial interactions
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- RNA and protein synthesis mechanisms
- Intracranial Aneurysms: Treatment and Complications
Loyola University Medical Center
2022-2025
Boca Raton Regional Hospital
2021-2024
Georgetown University
2021-2023
Nova Southeastern University
2023
Argonne National Laboratory
1977-2023
University Health System
2023
Loyola Medicine
2023
University at Buffalo, State University of New York
2018-2022
Loyola University Chicago
2022
University of Chicago
2022
Activation of angiotensin-converting enzyme 2 (ACE2), production angiotensin-(1-7) [Ang-(1-7)] and stimulation the Ang-(1-7) receptor Mas exert beneficial actions in various peripheral cardiovascular diseases, largely through opposition deleterious effects angiotensin II via its type 1 receptor. Here we considered possibility that may against CNS damage neurological deficits produced by cerebral ischaemic stroke. We determined central administration or pharmacological activation ACE2 on...
Breakthrough SARS-CoV-2 infections following vaccination against COVID-19 are of international concern. Patients with cancer have been observed to worse outcomes associated during the pandemic. We sought evaluate clinical characteristics and patients who developed breakthrough after 2 or 3 doses mRNA vaccines.
A leukemia helper virus indigenous to the Moloney isolate of sarcoma was isolated in pure form from an infected clone 3T3 cells. The has been propagated chronically cell subline (IC line) for over 70 weekly transfers. Morphologically IC line does not show overt signs viral transformation. cells contained no detectable but they produced high titers a (IC) defective sarcoma. This could be indefinitely other susceptible murine Attempts at superinfection by either Rauscher or pseudotypes showed...
The Rauscher leukemia virus separated as a single band upon density gradient centrifugation in cesium chloride, rubidium sucrose, potassium citrate, or tartrate. Prolonged exposure to concentrated citrate tartrate solutions caused lysis of the virus; resulting products, having different densities, on gradients.
Infection of cat embryo cells by a centrifugally induced aggregate murine sarcoma virus and feline leukemia gave rise to defective, focus-forming which propagated in cells, but not mouse cells. This virus, apparently enveloped with coat, was later subjected aggregation whereupon it regained the capacity for growth
Stocks of inurine sarcoma virus show titration patterns ranging from one-to two-hit kinetics. The comparison various titrations this virus, both with and without added helper to theoretical model systems composed defined constituents, suggests the existence a that does not need coinfecting murine leukemia be manifested as focus-forming unit. behavior such nondefective particles is compatible postulated leukemia-sarcoma hybrid.
On the basis of results ZUMA-3 trial, brexucabtagene autoleucel (brexu-cel), a CD19-directed chimeric antigen receptor T-cell therapy, gained US Food and Drug Administration approval in October 2021 for adults with relapsed/refractory (R/R) B-cell ALL (B-ALL). We report outcomes patients treated brexu-cel as standard therapy.
Endogenous levels of angiotensin II (Ang II) are increased in the cortex and hypothalamus following stroke, Ang type 1 receptor blockers (ARBs) have been shown to attenuate deleterious effects animal stroke models using middle cerebral artery (MCA) intraluminal occlusion procedures. However, endothelin-1 (ET-1)-induced (MCAO) model ischaemia is thought more closely mimic temporal events an embolic stroke. This method provides rapid MCA a gradual reperfusion that lasts for 16-22 h. The aim...
OBJECT Ventriculostomy occlusion is a known complication after external ventricular drain (EVD) placement. There have been no prospective published series that primarily evaluate the incidence of and risk factors for EVD occlusion. These phenomena are investigated using database. METHODS An ongoing study all patients undergoing frontal placement in Neurosurgery Intensive Care Unit at University Florida was accessed purposes this analysis. Demographic, procedural, radiographic data were...
Murine sarcoma virus apparently coated with feline leukemia envelope [MSV (FelLV)] could, in association virus, morphologically alter and actively replicate various human cell cultures. New defective MSV (FelLV) cat which could grow both cells cells, were produced. exhibited selective tissue tropism required active growth. Human embryo cultures be chronically infected either or FelLV alone. In embryonic lung a cell-free passage of the complex established. Cat per se also infect productively...
Takayasu arteritis (TA) is an idiopathic large-vessel vasculitis that can result in significant morbidity and mortality secondary to progressive stenosis occlusion. Monitoring disease progression crucial preventing relapse, but often complicated by the lack of clinical symptoms setting active disease. Although acute phase reactants such as ESR CRP are generally used indicator inflammation activity, mounting evidence suggests these markers cannot reliably distinguish from inactive TA.We...
Abstract Background Previous studies suggest that nonurgent pages comprise a substantial portion of the received by residents while on duty. We evaluated number, type, and urgency task being performed at time paging on-call junior neurosurgery large teaching hospital, with aim providing insight into mechanisms can be developed to improve patterns ultimately reduce physician distractions due communications. Methods For eight 12-hour call sessions, medical student shadowed resident recorded...