A5009918421- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Toxoplasma gondii Research Studies
- Research on Leishmaniasis Studies
- SARS-CoV-2 and COVID-19 Research
- Advanced Radiotherapy Techniques
- Ultrasound and Hyperthermia Applications
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Obesity, Physical Activity, Diet
- Hepatocellular Carcinoma Treatment and Prognosis
- Trypanosoma species research and implications
- Economic and Financial Impacts of Cancer
- Infection Control and Ventilation
- HIV/AIDS drug development and treatment
- Science and Education Research
- Healthcare cost, quality, practices
- Toxin Mechanisms and Immunotoxins
- Pancreatic and Hepatic Oncology Research
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Cervical Cancer and HPV Research
- Genetic Associations and Epidemiology
- HIV Research and Treatment
McGill University Health Centre
2022
Jewish General Hospital
2021
Discovery Institute
2015-2019
Sanford Burnham Prebys Medical Discovery Institute
2015-2019
Universidade Federal de Minas Gerais
2007-2016
Fundação Oswaldo Cruz
2012-2014
Vaccination is an important preventive health measure to protect against symptomatic and severe COVID-19. Impaired immunity secondary underlying malignancy or recent receipt of antineoplastic systemic therapies can result in less robust antibody titers following vaccination possible risk breakthrough infection. As clinical trials evaluating COVID-19 vaccines largely excluded patients with a history cancer those on active immunosuppression (including chemotherapy), limited evidence available...
Breakthrough SARS-CoV-2 infections following vaccination against COVID-19 are of international concern. Patients with cancer have been observed to worse outcomes associated during the pandemic. We sought evaluate clinical characteristics and patients who developed breakthrough after 2 or 3 doses mRNA vaccines.
Retinochoroiditis manifests in patients infected with Toxoplasma gondii. Here, we assessed 30 sibships and 89 parent/case trios of presumed ocular toxoplasmosis (POT) to evaluate associations polymorphisms the NOD2 gene. Three haplotype-tagging single-nucleotide (tag-SNPs) within gene were genotyped. The family-based association test showed that tag-SNP rs3135499 is associated retinochoroiditis (P = .039). We then characterized cellular immune response 59 cases POT 4 active (AOT). found no...
Background Visceral leishmaniasis (VL) is a severe vector-born disease of humans and dogs caused by Leishmania donovani complex parasites. Approximately 0.2 to 0.4 million new human VL cases occur annually worldwide. In the world, these alarming numbers are primarily due impracticality current control methods based on vector reduction dog euthanasia. Thus, prophylactic vaccine appears be essential for control. The efforts develop an efficacious include use animal models that as close VL. We...
ABSTRACT Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a member of the IRAK family and has an important role in inducing production inflammatory mediators. This downstream MyD88, adaptor protein essential for Toll-like (TLR) function. We investigated this IRAK4-deficient mice orally infected with cystogenic ME49 strain Toxoplasma gondii . IRAK4 −/− displayed higher morbidity, tissue parasitism, accelerated mortality than control mice. The lymphoid follicles germinal centers...
Abstract It has been suggested that Chlamydia trachomatis (CT) and human papillomaviruses (HPV) co‐infection could contribute to development of intraepithelial lesions. In this study, HPV CT‐DNA were investigated in 250 cervicovaginal samples patients from Minas Gerais, Brazil. The cytological analysis revealed 70% (175) negative, 5.2% (13) presented atypical squamous or glandular cells undetermined significance (ASCUS/AGUS), 12.4% (31) low‐grade lesion (LSIL), 10.8% (27) high‐grade (HSIL),...
Influenza A virus (IAV) is a human respiratory pathogen that causes yearly global epidemics, as well sporadic pandemics due to adaptation of pathogenic strains. Efficient replication IAV in different species is, part, dictated by its ability exploit the genetic environment host cell. To investigate tropism cells, we evaluated strains diverse subset epithelial cell lines. HeLa cells were refractory growth H1N1 and H3N2 viruses low-pathogenic avian influenza (LPAI) viruses. Interestingly,...
We aimed to estimate the heritability and genetic correlation between glucose homeostasis adiposity traits in a population rural community Brazil. The Jequitinhonha Community Family Study cohort consists of subjects aged ≥18 years residing areas data on following were assembled for 280 individuals (51.7% women): body mass index (BMI), fat percentage, waist mid-upper arm circumferences, triceps skinfold, conicity index, insulin, glucose, high-density lipoprotein cholesterol (HDLc),...
Objectives The purpose of this study was to estimate the heritability genetic and environmental correlations between cardiometabolic risk factors in extended pedigrees. Methods Jequitinhonha Community Family Study Cohort (JCFSC) consists individuals aged ≥18 years living rural villages. pedigrees were constructed cohort. following data collected: demographic socioeconomic status, lifestyle variables, anthropometrics, lipid traits. Results JCFSC 931 distributed into 69 with 4,907 members...
Background: Breakthrough SARS-CoV-2 infections following vaccination against COVID-19 are of international concern. Patients with cancer have been observed to worse outcomes associated during the pandemic. We sought evaluate clinical characteristics and patients who developed breakthrough after 2 or 3 doses mRNA vaccines.Methods: evaluated using data from multi-institutional Cancer Consortium (CCC19; NCT04354701). Analysis was restricted laboratory-confirmed diagnosed in 2021 2022, allow for...
Data regarding outcomes among patients with cancer and co-morbid cardiovascular disease (CVD)/cardiovascular risk factors (CVRF) after SARS-CoV-2 infection are limited. To compare Coronavirus 2019 (COVID-19) related complications without CVD/CVRF. Retrospective cohort study of laboratory-confirmed SARS-CoV-2, reported to the COVID-19 Cancer Consortium (CCC19) registry from 03/17/2020 12/31/2021. CVD/CVRF was defined as established CVD or no CVD, male ≥ 55 female 60 years, one additional...
Abstract Background and study aims Pancreatic cancer is a devastating disease with limited locoregional treatment options. Diffusing alpha-emitter radiation therapy (Alpha DaRT), novel using alpha-particle interstitial radiotherapy, may help address this challenge. The aim of was to evaluate the feasibility safety endoscopic ultrasound (EUS)-guided Alpha DaRT for advanced pancreatic cancer. Patients methods inoperable locally or metastatic adenocarcinoma were treated EUS-guided insertion....