A5032044615- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Lipid Membrane Structure and Behavior
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Chemical Synthesis and Analysis
- Polydiacetylene-based materials and applications
- Analytical Chemistry and Sensors
- Advanced Chemical Sensor Technologies
- Venomous Animal Envenomation and Studies
- Conducting polymers and applications
- Advanced oxidation water treatment
- Carbon and Quantum Dots Applications
- Forensic Toxicology and Drug Analysis
- Environmental remediation with nanomaterials
- Nanomaterials for catalytic reactions
- Quantum Dots Synthesis And Properties
- Neurobiology and Insect Physiology Research
- Analytical chemistry methods development
- Insect and Pesticide Research
- Protein Hydrolysis and Bioactive Peptides
- Peptidase Inhibition and Analysis
- Phytochemicals and Antioxidant Activities
- Force Microscopy Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
Universidade Federal dos Vales do Jequitinhonha e Mucuri
2016-2025
Departamento de Ciência e Tecnologia
2025
Universidade Federal de Minas Gerais
2007-2020
Federal University of São João del-Rei
2020
Bioactive peptides are promising therapeutic agents due to their antimicrobial and anticancer activities, although lack of selectivity often limits clinical applications. This study demonstrates the optimal synthetic route for conjugating folic acid (FA) with bioactive peptide Lunatin-1, aiming improve neoplastic cells. The synthesis combines solid-phase (SPPS) Cu(I)-catalyzed cycloaddition link Lunatin-1 via a triazole ring. Using model tripeptide FIG-NH2, key intermediates final product...
O presente trabalho apresenta uma metodologia simples, rápida e de baixo custo para determinação simultânea paracetamol (PC) ibuprofeno (IB) em formulações farmacêuticas por voltametria pulso diferencial usando eletrodo diamante dopado com boro (BDD).Os analitos apresentaram picos oxidação definidos 0,85 V o PC 1,72 IB (vs.Ag/AgCl) sobre BDD meio solução H 2 SO 4 0,1 mol L -1 10% (v/v) etanol.As curvas calibração mostraram resposta linear dos entre 20 a 400 μmol (r = 0,999) os limites...
The heterodimeric antimicrobial peptide distinctin is composed of 2 linear chains 22- and 25-aa residues that are connected by a single intermolecular S-S bond. This heterodimer has been considered to be unique example previously unrecorded class bioactive peptides. Here the were prepared chemical synthesis in quantitative amounts labeled with (15)N, as well (15)N (2)H, at selected residues, respectively, was formed oxidation. CD spectroscopy indicates high content helical secondary...
The biological activity of antimicrobial peptides and proteins is closely related to their structural aspects sensitive certain post-translational modifications such as glycosylation, lipidation PEGylation. However, PEGylation protein peptide drugs has expanded in recent years due the reduction toxicity. Due size, process can either preserve or compromise overall structure these biopolymers properties. LyeTx I-b cys was synthesized by Fmoc strategy coupled polyethylene glycol 2.0 kDa....
The antimicrobial peptide LyeTxI isolated from the venom of spider Lycosa erythrognatha is a potential model to develop new antibiotics against bacteria and fungi. In this work, we studied derived LyeTx I, named LyeTxI-b, characterized its structural profile in vitro vivo activities. Compared LyeTxI, LyeTxI-b has an acetylated N-terminal deletion His residue, as modifications. secondary structure well-defined helical segment, second amino acid amidated C-terminal, with no clear partition...
Background/Objectives: This study investigates the structural and biophysical properties of wild-type antimicrobial peptide LyeTx I, isolated from venom spider Lycosa erythrognatha, its analog I-b, designed to enhance antibacterial activity, selectivity, membrane interactions by acetylation increased amphipathicty. Methods: To understand mechanisms behind these enhanced properties, comparative analyses structural, topological, biophysical, thermodynamic aspects between each phospholipid...
Emerging bacterial infections pose a serious threat to human health. Acinetobacter baumannii is particular concern due its antimicrobial resistance phenotypes, especially carbapenems. In this context, peptides appear as promising class. Jelleine-I peptide identified from the royal jelly Apis mellifera bee, which has demonstrated significant antibacterial effects against various microorganisms. This study aimed characterize activity of jelleine-I clinical isolates A. resistant carbapenems...
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a multidrug-resistant (MDR) gram-negative bacterium frequently involved in hospital-acquired pneumonia. The infection caused by this superbug has spread quickly health centers worldwide, leading to high mortality rates. Due emerging scenario, the World Health Organization categorized CRKP as highest-priority species for development of new compounds. In context, antimicrobial peptides (AMPs) stand out prototypes alternative...
Abstract Antimicrobial peptides (AMPs) from amphibian skin are valuable template structures to find new treatments against bacterial infections. This work describes for the first time structure and membrane interactions of a homodimeric AMP. Homotarsinin, which was found in Phyllomedusa tarsius anurans, consists two identical cystine-linked polypeptide chains each 24 amino acid residues. The high-resolution monomeric dimeric were determined aqueous buffers. dimer exhibits tightly packed...