A5049572188- Chronic Myeloid Leukemia Treatments
- Colorectal Cancer Treatments and Studies
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- PARP inhibition in cancer therapy
- CAR-T cell therapy research
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Retinal Development and Disorders
- Neuroendocrine Tumor Research Advances
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Retinal Diseases and Treatments
- Peptidase Inhibition and Analysis
- Veterinary Oncology Research
- Cancer Research and Treatments
- Optical Coherence Tomography Applications
- Healthcare cost, quality, practices
- Glioma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
National Cancer Institute
2021-2025
National Institutes of Health
2021-2024
Center for Cancer Research
2023-2024
Fred Hutch Cancer Center
2019-2023
Virginia Mason Medical Center
2020-2023
Lam Research (United States)
2021
University of Washington
2013-2021
Clinical Research Management
2021
Michigan State University
2014-2018
Grand Rapids Community College
2014-2018
<h3>Importance</h3> Anthracycline-based therapy is standard first-line treatment for most patients with advanced and metastatic sarcomas. Although multiple trials have attempted to show improved outcomes in soft-tissue sarcoma over doxorubicin monotherapy, each has fallen short of demonstrating outcomes. <h3>Objective</h3> To evaluate the safety efficacy combination pembrolizumab advanced, anthracycline-naive <h3>Design, Setting, Participants</h3> This nonrandomized clinical trial used a...
Vaccination is an important preventive health measure to protect against symptomatic and severe COVID-19. Impaired immunity secondary underlying malignancy or recent receipt of antineoplastic systemic therapies can result in less robust antibody titers following vaccination possible risk breakthrough infection. As clinical trials evaluating COVID-19 vaccines largely excluded patients with a history cancer those on active immunosuppression (including chemotherapy), limited evidence available...
RNA-seq has spurred important gene fusion discoveries in a number of different cancers, including lung, prostate, breast, brain, thyroid and bladder carcinomas. Gene discovery can potentially lead to the development novel treatments that target underlying genetic abnormalities. In this study, we provide comprehensive view landscape 185 glioblastoma multiforme patients from two independent cohorts. Fusions occur approximately 30-50% GBM patient samples. Ivy Center cohort 24 patients, 33%...
// Biaoyang Lin 1, 2, 3 , Hwahyung Lee 4 Jae-Geun Yoon Anup Madan 4, 6 Elizabeth Wayner Sanja Tonning Parvinder Hothi Brett Schroeder Ilya Ulasov Gregory Foltz Leroy Hood 5 Charles Cobbs 1 Cancer Institute (Key Laboratory of Prevention and Intervention, China National Ministry Education), The Second Affiliated Hospital, Zhejiang University School Medicine, Hangzhou, 310003, 2 Dept. Urology, Washington, Seattle, WA 98195, USA System Biology Division, Zhejiang-California International...
Patients with relapsed small cell lung cancer (SCLC), a high replication stress tumor, have poor prognoses and few therapeutic options. A phase 2 study showed antitumor activity the addition of ataxia telangiectasia Rad3-related kinase inhibitor berzosertib to topotecan.
Despite promising preclinical studies, toxicities have precluded combinations of chemotherapy and DNA damage response (DDR) inhibitors. We hypothesized that tumor-targeted delivery might enable clinical translation such combinations.In a phase I trial, we combined sacituzumab govitecan, antibody-drug conjugate (ADC) delivers topoisomerase-1 inhibitor SN-38 to tumors expressing Trop-2, with ataxia telangiectasia Rad3-related (ATR) berzosertib. Twelve patients were enrolled across three dose...
Metastatic soft tissue sarcomas (STSs) have limited systemic therapy options, and immunomodulation has not yet meaningfully improved outcomes. Intratumoral (IT) injection of the toll-like receptor 4 (TLR4) agonist glycopyranosyl lipid A in stable-emulsion formulation (GLA-SE) been studied as immunotherapy other contexts.To evaluate safety, efficacy, immunomodulatory effects IT GLA-SE with concurrent radiotherapy patients metastatic STS injectable lesions.This phase 1 nonrandomized controlled...
Abstract Small‐cell lung cancer (SCLC) is the most lethal type of cancer. Specifically, MYC‐driven non‐neuroendocrine SCLC particularly resistant to standard therapies. Lurbinectedin was recently approved for treatment relapsed SCLC, but combinatorial approaches are needed increase depth and duration responses lurbinectedin. Using high‐throughput screens, we found inhibitors ataxia telangiectasia mutated rad3 related (ATR) as effective agents augmenting lurbinectedin efficacy. First‐in‐class...
It has been shown that after a visible stimulus, optical oscillations of nearly all cone photoreceptors can be observed using long coherence length light and in few cones short light. Here, we show exposure to imaging source reveals light-evoked oscillation signals large number cones. More than 80% given retinal area are activated (modulation the reflectance signal) stimulation, pattern their activation subjectively classified into one four categories. The application signal detection...
Background Dedifferentiated liposarcoma (DDLPS) is one of the most common soft tissue sarcoma subtypes and devastating in advanced/metastatic stage. Despite observation clinical responses to PD-1 inhibitors, little known about immune microenvironment relation patient prognosis. Methods We performed a retrospective study 61 patients with DDLPS. completed deep sequencing T-cell receptor (TCR) β-chain RNA for predictive modeling, evaluating both markers tumor escape genes. Hierarchical...
Abstract Metastasis is the leading cause of cancer-related deaths, yet its regulatory mechanisms are not fully understood. Small-cell lung cancer (SCLC) most metastatic form cancer, with patients presenting widespread disease, making it an ideal model for studying metastasis. However, lack suitable preclinical models has limited such studies. We utilized well-annotated rapid autopsy-derived tumors to develop xenograft that mimic key features SCLC, including histopathology, and development...
Abstract Background: Small cell lung cancer (SCLC) is the most aggressive type of with 5-year survival 7%. Besides chemotherapy, immune checkpoint blockade (ICB) part treatment regimen but only a subset patients derive benefit. Tumor tissue can identify distinct subtypes therapeutic vulnerabilities. Need for prompt and limited access to biopsies at relapse highlight demand noninvasive methods monitor response. Methods: We used sequential blood samples from relapsed/refractory SCLC enrolled...
Abstract One obstacle for human solid tumor immunotherapy research is the lack of clinically relevant animal models. In this study, we sought to establish a chimeric antigen receptor (CAR) T-cell treatment model naturally occurring canine sarcomas as CAR therapy. Canine CARs specific B7-H3 were constructed using single-chain variable fragment derived from B7-H3–specific antibody MGA271, which confirmed be cross-reactive with B7-H3. After refining activation, transduction, and expansion...
External ventricular drains (EVDs) measure intracranial pressure, divert cerebrospinal fluid, and allow for orthotropic administration of pharmacologic agents. Currently, neurosurgeons neurosurgery residents are the primary practitioners placing EVDs. Due to urgency neurosurgical pathologies lack qualified at most hospitals, midlevel practitioner (MLP) placement EVDs would be advantageous.To assess accuracy complication rates MLP neurosurgeon EVD placement.This was a retrospective cohort all...
// Ilya V. Ulasov 1, 4 , Nameeta Shah 1 Natalya Kaverina 2, 5 Hwahyang Lee Biaoyang Lin Andre Lieber 3 Zaira G. Kadagidze 2 Jae-Guen Yoon Brett Schroeder Parvinder Hothi Dhimankrishna Ghosh Anatoly Y. Baryshnikov Charles S. Cobbs Swedish Neuroscience Institute, Seattle, WA, 98122, USA NN. Blokhin Cancer Research Center, RAMN, Moscow, Russia, 115478 University of Washington, Institute Experimental Diagnostic and Biotherapy, Current address: Division Nephrology, 98109, Correspondence to:...
Ewing sarcoma (ES) is one of the most frequent types malignant tumors among children. The active metabolic state ES cells presents a new potential target for therapeutic interventions. As primary regulator cellular homeostasis, carbonic anhydrases (CAs; EC 4.2.1.1) have emerged as promising molecular targets development anticancer drugs. Within present study, we tested commercial drug acetazolamide and our previously discovered inhibitors to CAII isoform, which was overexpressed positively...
Targeted therapy development in soft tissue sarcoma (STS) has been burdened by the heterogeneity of this group rare tumors. B7 homolog 3 protein (B7-H3) is a molecule same family as programmed death-ligand 1 (PD-L1). It limited expression noncancerous tissues and overexpressed many cancers, making it an attractive target for cancer therapy, clinical trials targeting B7-H3 are actively underway. While available data demonstrate high levels individual subtypes, its patterns across STS subtypes...
Glioblastoma Multiforme (GBM) is a rapidly progressing brain tumor. Despite the relatively low percentage of cancer patients with glioma diagnoses, recent statistics indicate that number may have increased over past decade. Current therapeutic options for include tumor resection, chemotherapy, and concomitant radiation therapy an average survival approximately 16 months. The rapid progression gliomas has spurred development novel treatment options, such as gene oncolytic virotherapy....