A5018540261- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Chemistry and Chemical Engineering
- Radiomics and Machine Learning in Medical Imaging
- Molecular Junctions and Nanostructures
- Cancer Genomics and Diagnostics
- Force Microscopy Techniques and Applications
- Various Chemistry Research Topics
- Immune cells in cancer
- Nanofabrication and Lithography Techniques
- Health and Medical Research Impacts
- Cinema and Media Studies
- Lung Cancer Treatments and Mutations
- Single-cell and spatial transcriptomics
- History and advancements in chemistry
- Ferroptosis and cancer prognosis
- Colorectal and Anal Carcinomas
- Head and Neck Cancer Studies
- CAR-T cell therapy research
- Nanowire Synthesis and Applications
- Synthesis and Catalytic Reactions
- Science, Research, and Medicine
- Click Chemistry and Applications
Cofactor Genomics (United States)
2019-2023
American Chemical Society
2020-2022
Washington University in St. Louis
2010-2014
To characterize changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy with goal of informing immunotherapy trial design.Paired pre- and postneoadjuvant specimens were retrospectively identified for 32 patients STSs analyzed three modalities: multiplexed IHC, NanoString, RNA sequencing ImmunoPrism analysis.All patients, representing a variety STS histologic subtypes, received radiotherapy 21 (66%) chemotherapy prior to radiotherapy. The...
Background Dedifferentiated liposarcoma (DDLPS) is one of the most common soft tissue sarcoma subtypes and devastating in advanced/metastatic stage. Despite observation clinical responses to PD-1 inhibitors, little known about immune microenvironment relation patient prognosis. Methods We performed a retrospective study 61 patients with DDLPS. completed deep sequencing T-cell receptor (TCR) β-chain RNA for predictive modeling, evaluating both markers tumor escape genes. Hierarchical...
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy worldwide, as patients are typically diagnosed at a late stage and eventually develop chemoresistant disease following front-line platinum-taxane based therapy. Only modest results have been achieved with PD-1 immunotherapy in patients, despite fact that immunological responses observed EOC patients. Therefore, goal of this present study was to identify novel immune response genes cell subsets significantly associated...
Abstract Purpose Anti-PD-1 therapy provides clinical benefit in 40–50% of patients with relapsed and/or metastatic head and neck squamous cell carcinoma (RM-HNSCC). Selection anti- PD-1 is typically based on patient PD-L1 immunohistochemistry (IHC) which has low specificity for predicting disease control. Therefore, there a critical need biomarker that will predict to anti-PD-1 treatment high specificity. Methods Clinical outcomes data 103 RM-HNSCC were paired RNA-sequencing from...
Abstract The development of new surface coatings is critical for combating wear and increasing the device lifetime in microelectromechanical systems (MEMS). Here, a class arsonic acid self‐assembled monolayers (SAMs) reported that form readily on oxide substrates including silicon oxide, borosilicate glass, titanium oxide. Monolayers are easily prepared using straightforward soaking technique, which amenable to large‐scale commercial applications. Monolayer formation glass characterized...
The relationship between sequence, structure, and function is examined by comparing nineteen cyclic nucleotide monophosphate binding domains of known structure from six different functional families. Comparisons are made sequence alignment through the generation 3610 homology models. This analysis suggests there only weak relationships families, and/or structure. However, we have identified that for privileged template structures occur modeling. existence structures, capable creating...
Microcontact printing provides a rapid, highly reproducible method for the creation of well-defined patterned substrates.1 While microcontact can be employed to directly print large number molecules, including proteins,2 DNA,3 and silanes,4 formation self-assembled monolayers (SAMs) from long chain alkane thiols on gold simple way confine proteins cells specific patterns containing adhesive resistant regions. This confinement used control cell morphology is useful examining variety questions...
Abstract The International Younger Chemists Network (IYCN) began as a task force at the 2015 ACS National Meeting in Boston between group of young chemists from USA, Africa, Southeast Asia, and Europe. ultimate goal was to create unified international network for younger connect share ideas. Successful efforts led official launch IYCN an associated organization IUPAC 46th World Chemistry Congress (IUPAC2017) held Brazil.
Immunotherapies show promise in the treatment of oncology patients, but complex heterogeneity tumor microenvironment makes predicting response challenging. The ability to resolve relative populations immune cells present and around tissue has been shown be clinically-relevant understanding response, is limited by traditional techniques such as flow cytometry immunohistochemistry (IHC), due large amount required, lack accurate cell type markers, many technical logistical hurdles. One assay...
The ACS Younger Chemists Committee (YCC) was formed in 1974, with much of the groundwork for formation laid late 1960s and early 1970s, a time great unrest. environment, Vietnam War, Watergate, women’s rights were all controversial issues society, chemists midst many them. world continues to be both challenging exciting chemists. Politics, science, technology are evolving at rapid pace, this transformation is creating opportunities make an impact on changing world. Since its inception, YCC...
Immunotherapies show promise in the treatment of oncology patients, but complex heterogeneity tumor microenvironment makes predicting response challenging. The ability to resolve relative populations immune cells present and around tissue has been shown be clinically-relevant understanding response, is limited by traditional techniques such as flow cytometry immunohistochemistry (IHC), due large amount required, lack accurate cell type markers, many technical logistical hurdles. One assay...
If you're reading this, probably an American Chemical Society member who cares about what's going on in the field of chemistry. You may be one thousands young or early career members qualify as a "younger chemist." are likely to have opinions, comments, ideas chemistry education, job market, ACS, but don't know how your voice heard. this person, I want you that can make difference. Many groups within ACS eager for younger get involved. And governance is not just senior community; it's...
Supplementary Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
Supplementary Figure from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
Supplementary Figure from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
Supplementary Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells
<div>AbstractPurpose:<p>To characterize changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy with goal of informing immunotherapy trial design.</p>Experimental Design:<p>Paired pre- and postneoadjuvant specimens were retrospectively identified for 32 patients STSs analyzed three modalities: multiplexed IHC, NanoString, RNA sequencing ImmunoPrism analysis.</p>Results:<p>All patients, representing a...
<div>AbstractPurpose:<p>To characterize changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy with goal of informing immunotherapy trial design.</p>Experimental Design:<p>Paired pre- and postneoadjuvant specimens were retrospectively identified for 32 patients STSs analyzed three modalities: multiplexed IHC, NanoString, RNA sequencing ImmunoPrism analysis.</p>Results:<p>All patients, representing a...
In 2015, two years after I finished my graduate training, spoke with a journalist at U.S. News & World Report who was writing an article highlighting how Ph.D.-trained scientists were pursuing careers outside academia. The noted that, that time, only 42% of people Ph.D. in the sciences working Similarly, results from 2015 American Chemical Society ChemCensus survey chemical workforce showed 40.4% respondents reported academic sector. Recently, preparation for brainstorming lunch ACS national...