A5101985693- Pesticide Exposure and Toxicity
- Occupational exposure and asthma
- Circadian rhythm and melatonin
- Occupational and environmental lung diseases
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- Occupational Health and Safety Research
- Livestock Management and Performance Improvement
- Milk Quality and Mastitis in Dairy Cows
- Bladder and Urothelial Cancer Treatments
- Genetic and phenotypic traits in livestock
- Cancer Immunotherapy and Biomarkers
- Advanced Biosensing Techniques and Applications
- Effects of Environmental Stressors on Livestock
- Neuroblastoma Research and Treatments
- Thermoregulation and physiological responses
- Physiological and biochemical adaptations
- Automotive and Human Injury Biomechanics
- Anesthesia and Pain Management
- Transportation Safety and Impact Analysis
- Reproductive Physiology in Livestock
- Pesticide and Herbicide Environmental Studies
- Cholinesterase and Neurodegenerative Diseases
- Heat shock proteins research
- Lung Cancer Research Studies
Central Council for Research in Homoeopathy
2025
Central Research Institute
2025
National Cancer Institute
2021-2025
Center for Cancer Research
2021-2024
National Institutes of Health
2023-2024
Govind Ballabh Pant University of Agriculture and Technology
2023-2024
Banaras Hindu University
2014-2022
Wythenshawe Hospital
2010
Indian Institute of Toxicology Research
1987-2006
European Society of Anaesthesiology
2005
Cabozantinib and nivolumab (CaboNivo) alone or with ipilimumab (CaboNivoIpi) have shown promising efficacy safety in patients metastatic urothelial carcinoma (mUC), renal cell (mRCC), rare genitourinary (GU) tumors a dose-escalation phase I study. We report the final data analysis of safety, overall response rate (ORR), progression-free survival (PFS), (OS) seven expansion cohorts.
Topoisomerase III-beta (Top3b) reduces nucleic acid torsional stress and intertwining generated during RNA DNA metabolism while protecting the genome from pathological R-loops, which otherwise result in breakage instability. By studying Top3b knockout mice (Top3b-KO), we find that loss of accelerates development spontaneous lymphoid tumors arising spleens lymph nodes, organs with prominent expression. Aging Top3b-KO also display splenomegaly systemic immune alterations including neutrophilia...
Abstract Immune checkpoint blockade (ICB) combined with chemotherapy as a first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC) has shown modest survival benefits. While subset of patients immune-inflamed tumors respond to ICB, the mechanisms underlying these responses and lack predictive biomarkers in clinical practice remain challenges. In this work, we identify high NOTCH1 expression key predictor overall (OS) treated atezolizumab (atezo) plus both ASCL1-enriched (HR...
Abstract Background: Small cell lung cancer (SCLC) is the most aggressive type of with 5-year survival 7%. Besides chemotherapy, immune checkpoint blockade (ICB) part treatment regimen but only a subset patients derive benefit. Tumor tissue can identify distinct subtypes therapeutic vulnerabilities. Need for prompt and limited access to biopsies at relapse highlight demand noninvasive methods monitor response. Methods: We used sequential blood samples from relapsed/refractory SCLC enrolled...
Abstract ASCP is a rare and highly aggressive variant of pancreatic ductal adenocarcinoma (PDAC) with especially poor prognosis because it frequently refractory to standard chemotherapy. Previous work has demonstrated that upregulation the Myc oncogene an important driver ASCP. Minnelide oral superenhancer inhibitor drug downregulates expression in PDAC safe administer patients. In this Phase II, single institution, open label, arm study, patients previously treated, RECIST-measurable,...
Abstract Background ONC201 is a small molecule that can cause nonapoptotic cell death through loss of mitochondrial function. Results from the phase I/II trials in patients with refractory solid tumors demonstrated tumor responses and prolonged stable disease some patients. Methods This single-arm, open-label, II clinical trial evaluated efficacy at recommended dose (RP2D) recurrent or metastatic breast endometrial cancer. Fresh tissue biopsies blood were collected baseline cycle 2 day for...
The study was conducted to assess the magnitude of oxidative stress and lung function abnormalities in 34 male pesticide sprayers on exposure pesticides mango plantations. Biochemical studies blood antioxidant enzymes revealed an unchanged glutathione level increased malondialdehyde (P < 0.001), which indicates that may have suffered from stress. Decreased acetyl-cholinesterase levels 0.001) compared controls suggest inhibition cholinesterase activity. present shows toxicity might lead...
A medical and engineering study was made of 1074 car accidents involving 2520 vehicle occupants. The injuries they sustained were correlated with details the crash contact points inside cars. Where possible forces which generated in estimated related to injuries. In all, 39 occupants suffered femoral shaft fracture, an incidence 1.7% 0.8% for front rear seat respectively. Of these, 31 had associated other regions body; these cause 13 14 deaths this group. Associated more severe who not...
Data on 2520 occupants of cars involved in accidents were analysed relation to injury and the severity crash investigate effect rear seat passengers restrained unrestrained front vice versa. Unrestrained showed a higher incidence serious when there passengers. The presence passenger did not affect significantly overall among within range considered. behind moderate lower no than those occupants. It is concluded that legislation belts has greatly increased risk person injury.
To evaluate the long-term effects of metal dusts on bronchopulmonary system and synergistic effect cigarette smoke, a comparative study spirometric measurements in 104 polishers 90 unexposed controls was carried out 25 brass steelware polishing industries at Moradabad northern India. The two groups were comparable terms age, height, smoking habit socio-economic status. A total 58.6% had one or more respiratory symptoms, compared to only 25.5% (P<0.05). Chronic cough present 21 (20.2%) as...
Ampicillin is one of the most commonly prescribed antibiotics against intra-renal infections. Prolonged use ampicillin has been found to be associated with a high rate free-radical generation and oxidative stress induced nephrotoxicity. In present study, we report comparative effects melatonin vitamin-C (Vit-C) in ameliorating biochemical structural alterations renal tissues caused by sodium. Biochemical parameters such as acid phosphatase (ACP), alkaline (ALP), creatinine urea levels urine...