A5037240227- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Cancer Treatment and Pharmacology
- Chronic Myeloid Leukemia Treatments
- Cardiac Arrhythmias and Treatments
- Single-cell and spatial transcriptomics
- Atrial Fibrillation Management and Outcomes
- Peptidase Inhibition and Analysis
- Semiconductor materials and devices
- Integrated Circuits and Semiconductor Failure Analysis
- Solar Thermal and Photovoltaic Systems
- Viral Infectious Diseases and Gene Expression in Insects
- Peripheral Neuropathies and Disorders
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cancer therapeutics and mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Virus-based gene therapy research
- Solar Energy Systems and Technologies
University of Chicago
2024
The University of Texas MD Anderson Cancer Center
2018-2024
NorthShore University HealthSystem
2024
The University of Texas Health Science Center at Houston
2021-2024
Evanston Hospital
2024
Ganpat University
2022-2024
Rowan University
2020-2024
Anderson University - South Carolina
2024
Sant Gadge Baba Amravati University
2023
Karnavati University
2023
53BP1 is a chromatin-associated protein that regulates the DNA damage response. In this study, we identify TPX2/Aurora A heterodimer, nominally considered mitotic kinase complex, as novel binding partner of 53BP1. We find plays previously unrecognized role in repair and replication fork stability by counteracting function. Loss TPX2 or Aurora compromises end resection, BRCA1 Rad51 recruitment, homologous recombination. Furthermore, loss causes deprotection stalled forks upon stress...
Abstract Outcomes for diffuse large B-cell lymphoma (DLBCL) patients relapsing after autologous hematopoietic cell transplantation (auto-HCT) have been historically poor. We studied outcomes of such using data from 4 centers. Eligibility criteria included adult (age ≥18 years) with DLBCL experiencing disease relapse auto-HCT performed during 2006 to 2015. The time period was stratified into 2 eras (era 1, 2006-2010; era 2, 2011-2015). primary end point postrelapse overall survival (PR-OS)....
Key Points PR-OS of cHL patients has improved in recent years, likely due to incorporation novel therapies and more effective use allo-HCT. Future research should focus on earlier integration for with refractory disease improve outcomes further.
Patients with multiple myeloma t(11;14) have been considered to standard-risk disease. However, several recent reports shown contradictory results. We identified 95 patients on FISH studies, who underwent upfront autologous hematopoietic stem cell transplant (auto-HCT) at our center. compared their outcome a group of had diploid cytogenetics by both conventional (CC) and (n = 287).To reduce the bias between groups, we performed 1:1 propensity score matching technique for analysis. A total...
Chimeric antigen receptor T-cell (CAR-T) therapy, despite being a potentially curative therapy in relapsed or refractory (RR) large B-cell lymphoma (LBCL), remains underutilized older patients due to limited clinical data. We therefore studied the safety and efficacy of CAR-T with RR LBCL real-world setting. Patients aged ≥65 years LBCL, treated anti-CD19 at 7 US institutions were included this multicenter, retrospective, observational study. In total, 226 included. Median age infusion was...
Introduction: Immune checkpoint inhibitors (ICI), such as pembrolizumab, are an effective immunotherapy for several malignancies, however, have been associated with adverse events including myocarditis and accelerated atherosclerosis. ICI is a mortality rate of up to 33%. This case reports patient on pembrolizumab atypical presentation. Case presentation: A 75-year-old female past medical history significant lung cancer myasthenia gravis presented the hospital dyspnea mild, intermittent...
Patients with periodontitis are significantly more likely to have undetected diabetes mellitus (DM). Self‑monitoring devices like glucometers provide a simple method for rapid monitoring of the glucose level in blood by utilizing sample from finger, but this requires puncturing obtain blood. Bleeding gingival sulcus, obtained during oral hygiene examination, can be utilized screening DM patients. Therefore, study was performed aim determining efficacy crevicular as non-invasive patients,...
In this retrospective analysis, we evaluated the impact of age on outcome patients with multiple myeloma who received an autologous hematopoietic stem cell transplantation (auto-HCT) at our institution. A total 1128 were divided into older (>70 years; 182 [16%]) and younger (≤70 946 [84%]) groups. Compared cohort, had a higher International Staging System (ISS) stage (ISS-II, 57 [31%] versus 215 [23%]; ISS-III, 52 [28%] 211 [22%]; P = .01), use reduced-dose melphalan as conditioning regimen...
The cell of origin (COO) classification into germinal center B (GCB) and non-GCB types has been shown to predict survival outcomes in newly diagnosed diffuse large lymphoma (DLBCL). In the relapsed/refractory (R/R) setting, there is building evidence that COO does not prognosis after high-dose chemotherapy autologous stem transplantation (auto-SCT). present analysis aimed compare based on R/R DLBCL patients who underwent auto-SCT. This retrospective study included adult with auto-SCT at MD...
Background: Bruton tyrosine kinase inhibitors, such as ibrutinib, are medications that actively used for Chronic Lymphocytic Leukemia (CLL) and several lymphomas. They work by inhibiting Bruton’s therefore affecting B cell proliferation. Ibrutinib itself is associated with multiple cardiotoxicities including atrial fibrillation, ventricular arrhythmias, heart failure, bleeding. There well-established studies show the incidence of fibrillation ibrutinib therapy. However, only a few reports an...
Solar cooker with different collector like evacuated tubes collector, parabolic trough flat plate and Scheffler reflector etc are generally used for the cooking food SHSMs or PCMs. Present research article, combined heat storage material (one SHSM one PCM) late-evening has been experimentally investigated. One is placed within inner pot of a solar cooker, while another outer cooker. Six combinations formed from various (sand, pebbles, iron pieces) PCM (acetamide). During daytime, absorbed...