A5002087124- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Particle physics theoretical and experimental studies
- Liver Disease Diagnosis and Treatment
- Amoebic Infections and Treatments
- High-Energy Particle Collisions Research
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Renal cell carcinoma treatment
- Liver Disease and Transplantation
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Infectious Diseases and Tuberculosis
- Nanoplatforms for cancer theranostics
- Neuroendocrine Tumor Research Advances
- MRI in cancer diagnosis
- Pleural and Pulmonary Diseases
- Diagnosis and treatment of tuberculosis
- Medical Imaging and Pathology Studies
- Venous Thromboembolism Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Gallbladder and Bile Duct Disorders
- Head and Neck Surgical Oncology
Swami Rama Himalayan University
2022-2025
University of Hull
2011-2024
The University of Texas MD Anderson Cancer Center
2014-2024
University Hospital Southampton NHS Foundation Trust
2012-2024
Scripps MD Anderson Cancer Center
2024
Société d'Étude de l'Environnement (Switzerland)
2024
University of California, Los Angeles
2024
Hospital Authority
2023
Chinese University of Hong Kong
2023
York Teaching Hospital NHS Foundation Trust
2020-2023
The Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial represents the first completed prospective, biopsy-mandated, biomarker-based, adaptively randomized study in 255 pretreated lung cancer patients. Following an initial equal randomization period, chemorefractory non-small cell (NSCLC) patients were to erlotinib, vandetanib, erlotinib plus bexarotene, or sorafenib, based on relevant molecular biomarkers analyzed fresh core needle biopsy...
Evaluate the activity of everolimus (RAD001) in combination with octreotide long-acting repeatable (LAR) patients advanced low- to intermediate-grade neuroendocrine tumors.Treatment consisted RAD001 5 mg/d (30 patients) or 10 and LAR 30 mg every 28 days. Thirty carcinoid islet cell were enrolled.Intent-to-treat response rate was 20%. Per protocol, there 13 partial responses (22%), 42 stable disease (SD; 70%), five progressive (8%). Overall median progression-free survival (PFS) 60 weeks....
The objective of this study was to determine the prognostic variables that influence response and survival in patients with metastatic neuroendocrine tumors who are treated hepatic arterial embolization (HAE) or chemoembolization (HACE).Patients underwent HAE HACE were included retrospective study. Follow-up imaging studies compared baseline radiologic response. Progression-free (PFS) overall (OS) calculated using Kaplan-Meier method. Univariate multivariate analyses performed assess...
Abstract Immunotherapy has only limited efficacy against pancreatic ductal adenocarcinoma (PDAC) due to the presence of an immunosuppressive tumor-associated stroma. Here, we demonstrate effective modulation that stroma by irreversible electroporation (IRE), a local ablation technique received regulatory approval in United States. IRE induces immunogenic cell death, activates dendritic cells, and alleviates stroma-induced immunosuppression without depleting tumor-restraining collagen. The...
Percutaneous treatment of liver abscesses: needle aspiration versus catheter drainage.C L Rajak, S Gupta, Jain, Y Chawla, M Gulati and SuriAudio Available | Share
To determine the accuracy of percutaneous computed tomography (CT)-guided fine-needle aspiration biopsy (FNAB) small (< or =1.0-cm in diameter) pulmonary lesions.Sixty-one patients (34 men and 27 women) 21-89 years old (mean age, 61.3 years) with lung nodules 1.0 cm smaller underwent CT-guided transthoracic FNAB. Fifty-seven 61 had an underlying primary malignancy. Maximum nodule diameters were 0.5-0.7 10 0.8-1.0 51 patients. Cytopathologic evaluation FNAB samples was immediate all...
Background: There are limited studies in the literature comparing plain radiography, US and CT evaluation of intestinal obstruction. We carried out this prospective study to compare relative efficacies these three imaging techniques patients with Material Methods: Thirty-two presenting clinical suspicion obstruction were subjected findings compared reference presence or absence obstruction, level cause The final diagnosis was obtained by surgery (n=25), contrast and/or follow-up those who...
Abstract Purpose: We sought to determine whether phosphoinositide 3-kinase (PI3K) pathway mutation or activation state and rapamycin-induced feedback loop of Akt is associated with rapamycin sensitivity resistance. Experimental Design: Cancer cell lines were tested for sensitivity, phosphorylation, mTOR target inhibition. Mice injected breast neuroendocrine cancer cells patients tumor (NET) treated rapalogs phosphorylation was assessed. Results: Thirty-one sensitive (RS) 12 relatively...
Abstract Photothermal ablation (PTA) is an emerging technique that uses near-infrared (NIR) laser light–generated heat to destroy tumor cells. However, complete eradication by PTA therapy alone difficult because heterogeneous distribution can lead sublethal thermal dose in some areas of the tumor. Successful requires selective delivery photothermal conducting nanoparticles mediate effective cells, and ability combine with other modalities. Here, we synthesized multifunctional doxorubicin...
Carcinoid tumors have a predilection for metastasizing to the liver. The presence of liver metastases is associated with poor prognosis and also results in significant deterioration patient's quality life. Several reports suggest that hepatic artery embolization or chemoembolization can be used control disease these patients. We retrospectively reviewed our experience use arterial patients liver-dominant metastatic carcinoid disease, evaluating clinical radiologic response rates, duration...
By applying the principles of real-time biopsy, biomarker-based, adaptively randomized studies in non-small-cell lung cancer (NSCLC) established by Biomarker-Integrated Approaches Targeted Therapy for Lung Cancer Elimination (BATTLE) trial, we conducted BATTLE-2 (BATTLE-2 Program: A Study Previously Treated Patients With Advanced Non-Small Cell Cancer), an umbrella study to evaluate effects targeted therapies focusing on KRAS-mutated cancers.Patients with advanced NSCLC (excluding...
Abstract Despite advances in controlled drug delivery, reliable methods for activatable, high‐resolution control of release are needed. The hypothesis that the photothermal effect mediated by a near‐infrared (NIR) laser and hollow gold nanospheres (HAuNSs) could modulate anticancer agents is tested with biodegradable biocompatible microspheres (1–15 µm) containing antitumor paclitaxel (PTX) HAuNSs (≈35 nm diameter), which display surface plasmon absorbance NIR region. HAuNS‐containing...
Severe renal injuries after blunt trauma cause diagnostic and therapeutic challenges for the treating clinicians. The need an operative vs a nonoperative approach is debated.To determine rate, causes, predictors, consequences of failure management (NOM) in grade IV V (BRIs).Retrospective case series.Twelve level I II centers New England.A total 206 adult patients with or BRI who were admitted between January 1, 2000, December 31, 2011.Failure NOM, defined as delayed operation death due to...
Abstract Background Percutaneous ablation is a common treatment for colorectal liver metastasis (CLM). However, the effect of rat sarcoma viral oncogene homologue (RAS) mutation on outcome after CLMs unclear. Methods Patients who underwent image-guided percutaneous from 2004 to 2015 and had known RAS status were analysed. evaluated local tumour progression as observed imaging treated with ablation. Multivariable Cox regression analysis was performed determine factors associated...
GNAS encodes the Gαs (stimulatory G-protein alpha subunit) protein, which mediates G protein-coupled receptor (GPCR) signaling. mutations cause developmental delay, short stature, and skeletal abnormalities in a syndrome called Albright's hereditary osteodystrophy. Because of imprinting, on maternal allele also obesity hormone resistance (pseudohypoparathyroidism).We performed exome sequencing targeted resequencing 2548 children who presented with severe obesity, we unexpectedly identified...