A5001295453- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Statistical Methods and Inference
- Colorectal Cancer Treatments and Studies
- Advanced Proteomics Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Inflammatory mediators and NSAID effects
- Bayesian Methods and Mixture Models
- Peroxisome Proliferator-Activated Receptors
- Cancer Research and Treatments
- Mass Spectrometry Techniques and Applications
- Growth Hormone and Insulin-like Growth Factors
- Cancer Cells and Metastasis
- Statistical Methods and Bayesian Inference
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Bioinformatics and Genomic Networks
- COVID-19 epidemiological studies
- Molecular Biology Techniques and Applications
- Colorectal Cancer Screening and Detection
University of Pennsylvania
2020-2025
Columbia University
2024
California University of Pennsylvania
2020-2024
Philadelphia University
2021-2024
The University of Texas MD Anderson Cancer Center
2014-2023
University of Pittsburgh
2022-2023
University of Washington
2020
Children's Hospital of Philadelphia
2020
University of Michigan–Ann Arbor
2019
Johns Hopkins University
2019
Abstract Motivation: There has been much interest in using patterns derived from surface-enhanced laser desorption and ionization (SELDI) protein mass spectra serum to differentiate samples patients both with without disease. Such have used identification of the underlying proteins responsible. However, there are questions as stability this procedure over multiple experiments. Results: We compared SELDI proteomic three experiments by same group on separating ovarian cancer normal tissue....
In patients with locoregional carcinoma of the esophagus or esophagogastric junction who underwent preoperative chemoradiation, it is unclear whether survival was better predicted by pretherapy clinical stage posttherapy pathologic stage.The authors studied 235 consecutive Stage II, III, IVA (according to American Joint Committee on Cancer criteria) were treated chemoradiation followed esophagectomy. Posttherapy cancer status classified using and semiquantitative assessment residual...
Increasingly, scientific studies yield functional data, in which the ideal units of observation are curves and observed data consist sets that sampled on a fine grid. We present new methodology generalizes linear mixed model to framework, with fitting done by using Bayesian wavelet-based approach. This method is flexible, allowing functions arbitrary form full range fixed effects structures between-curve covariance available framework. It yields nonparametric estimates random-effects as well...
Functional data analysis (FDA) involves the of whose ideal units observation are functions defined on some continuous domain, and observed consist a sample taken from population, sampled discrete grid. Ramsay & Silverman's (1997) textbook sparked development this field, which has accelerated in past 10 years to become one fastest growing areas statistics, fueled by number applications yielding type data. One unique characteristic FDA is need combine information both across within...
The study objective was to determine the proportion of patients with hepatocellular carcinoma (HCC) treated combination bevacizumab (B) and erlotinib (E) who were alive progression free at 16 weeks (16-week progression-free survival [PFS16]) continuous therapy. Secondary objectives included response rate, median PFS, survival, toxicity.Patients had advanced HCC that not amenable surgical or regional therapies, up one prior systemic treatment; Childs-Pugh score A B liver function; Eastern...
Growth factor overexpression, including epidermal growth receptor (EGFR) expression, is common in hepatocellular cancers. Erlotinib a tyrosine kinase inhibitor with specificity for EGFR. The primary objective of this study was to determine the proportion carcinoma (HCC) patients treated erlotinib who were alive and progression-free (PFS) at 16 weeks continuous treatment.Patients unresectable HCC, no prior systemic therapy, performance status (PS) 0, 1, or 2, Childs-Pugh (CP) cirrhosis A B...
<h3>Importance</h3> Maternally derived antibodies are a key element of neonatal immunity. Understanding the dynamics maternal antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and subsequent transplacental transfer can inform management as well vaccination strategies. <h3>Objective</h3> To assess association between SARS-CoV-2–specific concentrations. <h3>Design, Setting, Participants</h3> This cohort study took place at...
Seasonal influenza vaccines offer little protection against pandemic virus strains. It is difficult to create effective prepandemic because it uncertain which subtype will cause the next pandemic. In this work, we developed a nucleoside-modified messenger RNA (mRNA)-lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known A subtypes and B lineages. This multivalent elicited high levels of cross-reactive subtype-specific antibodies in mice ferrets that reacted encoded...
Limited data are available for pregnant women affected by SARS-CoV-2. Serological tests critically important determining SARS-CoV-2 exposures within both individuals and populations. We validated a spike receptor binding domain serological test using 834 pre-pandemic samples 31 from COVID-19 recovered donors. then completed testing of 1,293 parturient at two centers in Philadelphia April 4 to June 3, 2020. found 80/1,293 (6.2%) possessed IgG and/or IgM SARS-CoV-2-specific antibodies....
In the West, curative (R0) resection is achieved in approximately 50% of patients with localized gastric carcinoma, and more than 60% die cancer following an R0 resection. A multi-institutional study preoperative chemoradiotherapy was done to assess rate, pathologic complete response (pathCR) safety, survival resectable carcinoma.Operable adenocarcinoma were eligible. Staging also included a laparoscopy endoscopic ultrasonography (EUS). Patients received up two 28-day cycles induction...
Mass spectrometry is being used to find disease-related patterns in mixtures of proteins derived from biological fluids. Questions have been raised about the reproducibility and reliability peak quantifications using this technology. We collected nipple aspirate fluid breast cancer patients healthy women, pooled them into a quality control sample, produced 24 replicate SELDI spectra. developed novel algorithm process spectra, denoising with undecimated discrete wavelet transform (UDWT),...
In contrasting levels of gene expression between groups SAGE libraries, the libraries within each group are often combined and counts for tag interest summed, inference is made on basis these larger 'pseudolibraries'. While this captures sampling variability inherent in procedure, it fails to allow normal variation individuals same group, can consequently overstate significance results. The effect not slight: between-library be hundreds times within-library variation.We introduce a...
Preoperative chemoradiotherapy may increase the R0 (curative) resection rate, overall survival (OS) duration, and disease-free (DFS) duration. We evaluated paclitaxel-based induction chemotherapy in patients with localized gastric or gastroesophageal adenocarcinoma to determine its feasibility, impact on type of pathologic response, OS, DFS.Patients operable, gastric, were eligible. Staging included endoscopic ultrasonography (EUS) laparoscopy. Patients received two 28-day cycles...
Adenocarcinomas of the small bowel and ampulla Vater represent rare cancers that have limited data regarding first-line therapy. We conducted a phase II trial to evaluate benefit capecitabine in combination with oxaliplatin (CAPOX) patients advanced adenocarcinoma or ampullary origin.Eligible metastatic unresectable tumors no prior systemic chemotherapy for disease participated this trial. CAPOX was administered as 21-day cycle 130 mg/m(2) on day 1 750 twice days through 14. The primary end...
Diminished apoptosis, a critical event in tumorigenesis, is linked to down-regulated 15-lipoxygenase-1 (15-LOX-1) expression colorectal cancer cells. 13-S-hydroxyoctadecadienoic acid (13-S-HODE), which the primary product of 15-LOX-1 metabolism linoleic acid, restores apoptosis. Nonsteroidal antiinflammatory drugs (NSAIDs) transcriptionally up-regulate induce Peroxisome proliferator-activated receptors (PPARs) are nuclear for and arachidonic metabolites. PPAR-delta promotes colonic...
Abstract Background: Recently, researchers have been using mass spectroscopy to study cancer. For use of proteomics spectra in a clinical setting, stringent quality-control procedures will be needed. Methods: We pooled samples nipple aspirate fluid from healthy breasts and with cancer prepare control sample. Aliquots the sample were used on two spots each three IMAC ProteinChip® arrays (Ciphergen Biosystems, Inc.) 4 successive days generate 24 SELDI spectra. In 36 subsequent experiments, was...
To evaluate whether preoperative portal vein embolization (PVE) with polyvinyl alcohol (PVA) particles and coils is safe effective for inducing lobar hypertrophy in patients hepatobiliary malignancy.PVE was performed 26 patients. All had malignancy: metastases (n = 11), cholangiocarcinoma 9), hepatocellular carcinoma 5), gallbladder 1). One patient underlying liver disease caused by hepatitis. PVE if the future remnant (FLR) estimated to be less than 25% of total volume. a percutaneous...
Colorectal neoplasm and coronary artery disease (CAD) share similar risk factors, their co-occurrence may be associated.To investigate the prevalence of colorectal in patients with CAD a cross-sectional study to identify predisposing factors for association 2 diseases.Patients Hong Kong, China, were recruited screening colonoscopy after undergoing angiography suspected during November 2004 June 2006. Presence (n = 206) was defined as at least 50% diameter stenosis any 1 major arteries;...
Abstract Motivation: Analyzing data from multi-platform genomics experiments combined with patients’ clinical outcomes helps us understand the complex biological processes that characterize a disease, as well how these relate to development of disease. Current integration approaches are limited in they do not consider fundamental relationships exist among obtained different platforms. Statistical Model: We propose an integrative Bayesian analysis (iBAG) framework for identifying important...
Local variation in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across United States has not been well studied.
Human tumor xenograft models do not replicate the human immune system and microenvironment. We developed an improved humanized mouse model, derived from fresh cord blood CD34+ stem cells (CD34+ HSC), combined it with lung cancer cell line-derived xenografts or patient-derived (Hu-PDX). Fresh HSCs could reconstitute detectable mature leukocytes (hCD45+) in mice at four weeks without onset of graft-versus-host disease (GVHD). Repopulated T cells, B natural killer (NK) dendritic (DC),...
Purpose Cirrhosis and hepatocellular carcinoma (HCC) together form a two-disease state that affects survival of patients with HCC dictates treatment decisions prognostic stratification in clinical trials. The study objective was to improve HCC. Patients Methods We prospectively collected plasma samples baseline clinicopathologic features from 288 new HCC, insulin-like growth factor-1 (IGF-1) vascular endothelial factor (VEGF) levels were tested. applied Cox regression log-rank tests assess...