Elizabeth M. Drapeau
A5046964576- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- CAR-T cell therapy research
- Vaccine Coverage and Hesitancy
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Animal Disease Management and Epidemiology
- vaccines and immunoinformatics approaches
- Respiratory viral infections research
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 detection and testing
- Lymphoma Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Animal Virus Infections Studies
- Cancer Immunotherapy and Biomarkers
- COVID-19 epidemiological studies
California University of Pennsylvania
2025
University of Pennsylvania
2021-2025
Philadelphia University
2022
Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding longevity vaccine-induced immune protection. Goel et al . examined B T lymphocyte responses in individuals who received SARS-CoV-2 messenger RNA vaccines. They performed a 6-month longitudinal study never had infection...
Seasonal influenza vaccines offer little protection against pandemic virus strains. It is difficult to create effective prepandemic because it uncertain which subtype will cause the next pandemic. In this work, we developed a nucleoside-modified messenger RNA (mRNA)-lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known A subtypes and B lineages. This multivalent elicited high levels of cross-reactive subtype-specific antibodies in mice ferrets that reacted encoded...
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system's own record antigen exposures encoded by receptors on B cells T cells. We analyzed receptor datasets from 593 individuals to develop MAchine Learning for Immunological Diagnosis, an interpretive framework screen multiple illnesses simultaneously or precisely test one condition. This approach detects specific...
ABSTRACT SARS-CoV-2 mRNA vaccines have shown remarkable efficacy, especially in preventing severe illness and hospitalization. However, the emergence of several variants concern reports declining antibody levels raised uncertainty about durability immune memory following vaccination. In this study, we longitudinally profiled both cellular responses naïve recovered individuals from pre-vaccine baseline to 6 months post-mRNA Antibody neutralizing titers decayed peak but remained detectable all...
Influenza viruses circulated at very low levels during the beginning of COVID-19 pandemic, and population immunity against these is low. An H3N2 strain (3C.2a1b.2a2) with a hemagglutinin (HA) that has several substitutions relative to 2021-22 vaccine dominating Northern Hemisphere influenza season. Here, we show one eliminates key glycosylation site on HA alters sialic acid binding. Using glycan array profiling, 3C.2a1b.2a2 H3 maintains binding an extended biantennary sialoside replicates...
Abstract Patients with B-cell lymphomas have altered cellular components of vaccine responses due to malignancy and therapy, the optimal timing vaccination relative therapy remains unknown. Severe acute respiratory syndrome coronavirus 2 vaccines created an opportunity for new insights in because patients were challenged a novel antigen across multiple phases treatment. We studied serologic messenger RNA response retrospective prospective cohorts lymphoma chronic lymphocytic leukemia, paired...
Abstract Human influenza viruses rapidly acquire mutations in their hemagglutinin (HA) protein that erode neutralization by antibodies from prior exposures. Here, we use a sequencing-based assay to measure titers for 78 recent H3N2 HA strains against large set of children and adult sera, measuring ∼10,000 total titers. There is substantial person-to-person heterogeneity the different viral strains, both within across age cohorts. The growth rates human population 2023 are highly correlated...
AbstractRecent surveillance has identified an expansion of swine H1 1C influenza viruses in Eurasian swine. Since 2010, at least twenty-one spillover events virus into humans have been detected and three these occurred from July to December 2023. Pandemic risk assessment revealed that individuals born after 1950 had limited cross-reactive antibodies, confirming they are antigenically novel viruses. The exhibited phenotypic signatures similar the 2009 pandemic H1N1 virus, including human...
Abstract Clinical diagnosis typically incorporates physical examination, patient history, and various laboratory tests imaging studies, but makes limited use of the human system’s own record antigen exposures encoded by receptors on B cells T cells. We analyzed immune receptor datasets from 593 individuals to develop MAchine Learning for Immunological Diagnosis (Mal-ID) , an interpretive framework screen multiple illnesses simultaneously or precisely test one condition. This approach detects...
SUMMARY Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth comparison GC responses elicited by SARS-CoV-2 mRNA vaccines in healthy immunocompromised individuals has not yet been performed due to challenge directly probing human lymph nodes. In this study, through a fine-needle-aspiration-based approach, we profiled immune nodes kidney transplant (KTX) recipients. We found...
Abstract Despite a clear role in protective immunity, the durability and quality of antibody memory B cell responses induced by mRNA vaccination, particularly 3 rd dose vaccine, remains unclear. Here, we examined cohort individuals sampled longitudinally for ∼9-10 months after primary 2-dose vaccine series, as well ∼3 dose. Notably, decay slowed significantly between 6- 9-months post-primary essentially stabilizing at time Antibody also continued to improve least 9 vaccination. Spike-...
Abstract Maternal antibodies (matAbs) protect against a myriad of pathogens early in life; however, these can also inhibit de novo immune responses some vaccine platforms. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) matAbs are efficiently transferred during pregnancy and infants subsequent SARS-CoV-2 infections. It is unknown if elicited by different types vaccines. Here, we established mouse model to determine spike-specific recombinant protein nucleoside-modified...
Abstract Influenza viruses have circulated at very low levels during the COVID-19 pandemic, and population immunity against these is low. virus cases been increasing in Northern Hemisphere involving an H3N2 strain (3C.2a1b.2a2) with a hemagglutinin (HA) that has several substitutions relative to 2021-2022 vaccine strain. Here, we show one of eliminates key glycosylation site on HA alters sialic acid binding. Using glycan array profiling, 3C.2a1b.2a2 H3 maintains binding extended bi-antennary...
Abstract Maternal antibodies (matAbs) protect against a myriad of pathogens early in life; however, these can also inhibit de novo immune responses some vaccine platforms. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) matAbs are efficiently transferred during pregnancy and infants subsequent SARS-CoV-2 infections. It is unknown if elicited by different types vaccines. Here, we established mouse model to determine spike-specific recombinant protein nucleoside-modified...
ABSTRACT Patients with B-cell lymphomas have altered cellular components of vaccine responses due to the malignancies and therapies. The optimal timing administration relative chemotherapy immunotherapy remains unknown. SARS-CoV-2 campaign created a unique opportunity gather insights into because patients were challenged novel antigen across multiple phases lymphoma management. We studied retrospective prospective cohorts CLL who received an mRNA-based paired serologic response treatment...
Abstract Background Maternal antibodies (matAbs) protect against a myriad of pathogens early in life; however, these can also inhibit de novo immune responses some vaccine platforms. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) matAbs are efficiently transferred during pregnancy and infants subsequent SARS-CoV-2 infections. It is unknown if elicited by different types vaccines. Methods We established mouse model to determine spike (S)-specific recombinant protein...