A5103038482- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Antimicrobial Resistance in Staphylococcus
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Animal Disease Management and Epidemiology
- Infectious Diseases and Tuberculosis
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Vibrio bacteria research studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Hepatitis C virus research
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Streptococcal Infections and Treatments
- Salmonella and Campylobacter epidemiology
- Trace Elements in Health
- Digital Imaging for Blood Diseases
- Galectins and Cancer Biology
Guangzhou Medical University
2017-2024
University of Pittsburgh
2021-2024
Third Affiliated Hospital of Guangzhou Medical University
2020-2022
Huazhong University of Science and Technology
2013-2014
Tongji Hospital
2014
Shenzhen International Travel Health Care Center
2009
Central South University
2005-2006
Third Xiangya Hospital
2005
COVID-19 has been diffusely pandemic around the world, characterized by massive morbidity and mortality. One of remarkable threats associated with mortality may be uncontrolled inflammatory processes, which were induced SARS-CoV-2 in infected patients. As there are no specific drugs, exploiting safe effective treatment strategies is an instant requirement to dwindle viral damage relieve extreme inflammation simultaneously. Here, highly biocompatible glycyrrhizic acid (GA) nanoparticles...
Abstract Influenza A viruses in swine have considerable genetic diversity and continue to pose a pandemic threat humans due potential lack of population level immunity. Here we describe pipeline characterize triage influenza for their risk examine the two widespread origin viruses. Our analysis reveals that panel human sera collected from healthy adults 2020 has no cross-reactive neutralizing antibodies against α-H1 clade strain (α-swH1N2) but do γ-H1 strain. The α-swH1N2 virus replicates...
CRKP has been registered in the critical priority tier by World Health Organization and become a significant menace to public health. The emergence of CR-HvKP is great concern terms both disease treatment.
Surveillance systems revealed that the prevalence of vancomycin-resistant
Carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP) causes serious infections with significant morbidity and mortality. However, the epidemiology transmission mechanisms of CR-hvKP corresponding carbapenem-resistant plasmids require further investigation. Herein, we have characterized an ST11 strain EBSI041 from blood sample encoding both hypervirulence carbapenem resistance phenotypes a patient in Egypt.K. showed multidrug-resistance phenotypes, where it was highly resistant to...
Interferon-gamma release assays (IGRAs) have proven to be useful accurately detect Mycobacterium tuberculosis (Mtb) infection, but they cannot reliably discriminate between active (TB) and latent infection (LTBI). This study aims test whether Mtb-specific tumor necrosis factor-alpha (TNF-α) could used as a new tool for the rapid diagnosis of TB disease. The secretion TNF-α by antigen-stimulated peripheral blood mononuclear cells (PBMCs) sixty seven participants was investigated in study. Our...
Abstract Mucosal-associated invariant T (MAIT) cells play a key role in local and systemic immune responses. Studies suggest that type 2 diabetes (T2D) is associated with alterations the human MAIT cell response. However, mechanisms regulate survival homeostasis of are poorly defined. In this study, we demonstrate costimulatory TNF superfamily receptor OX40 was highly expressed patients T2D. Compared OX40-negative cells, OX40-positive showed high activation memory phenotype. Surprisingly,...
To investigate the predictive value of clinical variables on poor prognosis at 90-day follow-up from acute stroke onset, and compare diagnostic performance between back propagation artificial neural networks (BP ANNs) Logistic regression (LR) models in predicting prognosis.We studied association functional recovery 435 ischemic patients. The patients were divided into 2 groups according to modified Rankin Scale scores evaluated 90th day after onset. Both BP ANNs LR established for outcome...
The aim of the present study was to investigate inhibitory effect Pseudomonas aeruginosa (PA) on pathogenic fungi, including Candida albicans (CA), tropicalis (CT), glabrata (CG), parapsilosis (CP) and krusei (CK), in vitro vivo. In total, 24 PA strains were collected from clinical specimens identified by Gram staining, oxidase production API 20NE system. Cross‑streak, disk diffusion co‑culture methods used observe PA. Sodium dodecyl sulfate‑polyacrylamide gel electrophoresis analyze...
Type I and type II CRISPR-Cas systems are employed to evade host immunity by targeting interference of bacteria's own genes. Although Mycobacterium tuberculosis (M. tuberculosis), the causative agent tuberculosis, possesses integrated III-A system, its role in mycobacteria remains obscure. Here, we observed that seven cas genes (csm2∼5, cas10, cas6) were upregulated bovis BCG under oxidative stress treatment, indicating system stress. To explore functional TCC (Type including cas6, csm2-6)...
Maternal COVID-19 vaccination could protect infants who are ineligible for vaccine through antibody transfer during pregnancy and lactation. We measured the quantity durability of SARS-CoV-2 antibodies in human milk infant blood before after maternal booster vaccination. Prospective cohort lactating women immunized with primary vaccines or lactation their infants. Milk samples from October 2021 to April 2022 were included. Anti-nucleoprotein (NP) anti-receptor binding domain (RBD) IgG IgA...
ABSTRACT Rift Valley fever virus (RVFV) causes mild to severe disease in humans and livestock. Outbreaks of RVFV have been reported throughout Africa spread outside since 2000, calling for urgent worldwide attention this emerging virus. directly infects the liver, elevated transaminases are a hallmark infection. However, specific contribution viral replication hepatocytes pathogenesis remains undefined. To address this, we generated recombinant miRNA-targeted virus, RVFVmiR-122, limit...
Seroprevalence studies are important for understanding the dynamics of local virus transmission and evaluating community immunity. To assess seroprevalence SARS-CoV-2 in Allegheny County, an urban/suburban county Western PA, 393 human blood samples collected Fall 2020 February 2021 were examined spike protein receptor-binding domain (RBD) nucleocapsid (N) antibodies. All RBD-positive evaluated virus-specific neutralization activity. Our results showed a 5.5% by RBD ELISA, 4.5% N 2.5% both...
Background The differential diagnosis between tuberculous meningitis (TBM) and bacterial (BM) remains challenging in clinical practice. This study aimed to establish a diagnostic model that could accurately distinguish TBM from BM. Methods Patients with or BM were recruited January 2017 2021 at Tongji Hospital (Qiaokou cohort) Sino-French New City (Caidian cohort). detection for indicators involved cerebrospinal fluid (CSF) T-SPOT assay performed simultaneously. Multivariate logistic...
Multi-locus sequence typing (MLST) can be used to analyze the homology among drug resistance gene cassettes in Salmonella and determine prevalence. Information extracted using this technique provide a theoretical basis for hospitals devise protocols control infections. The aim of present study was investigate possible association between integrons clinical isolates from human fecal samples. Therefore, study, 52 non-duplicate (i.e., not genome contamination) were harvested children with...
The present study aimed to investigate the association between drug resistance and class I, II III integrons in Acinetobacter baumannii (ABA). Multilocus sequence typing (MLST) is a tool used analyze homology among house‑keeping gene clusters ABA prevalence further provides theoretical basis for hospitals control infections. A total of 96 clinical isolates non‑repeating were harvested, including 74 carbapenem‑resistant (CRABA) 22 non‑CRABA strains, bacterial identification susceptibility...
ABSTRACT Influenza A viruses in swine have considerable genetic diversity and continue to pose a pandemic threat humans. They were the source of most recent influenza pandemic, since 2010, novel spilled over into humans more than 400 times United States. Although these zoonotic infections generally result mild illness with limited onward human transmission, potential for sustained transmission an emerging virus between individuals due lack population level immunity is great concern....