A5100340939- Antimicrobial Resistance in Staphylococcus
- Circular RNAs in diseases
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Bacterial Genetics and Biotechnology
- Immune Response and Inflammation
- Effects of Radiation Exposure
- Streptococcal Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Quality and Pollution
- Climate variability and models
- NF-κB Signaling Pathways
- Trace Elements in Health
- Microbial infections and disease research
- Meteorological Phenomena and Simulations
- Metalloenzymes and iron-sulfur proteins
Soochow University
2014-2025
Second Affiliated Hospital of Soochow University
2012-2025
Henan Normal University
2024
Tianjin Meteorological Bureau
2019
Institute of Microbiology
2017
Staphylococcus aureus is a common pathogen causing both hospital and community-acquired infections. Hemolysin one of the important virulence factors for S. causes typical β-hemolytic phenotype which called complete hemolytic as well. Recently, with an incomplete (SIHP) was isolated from clinical samples. To study microbiologic characteristics SIHP, special SIHP verified on sheep blood agar plates supplied by different manufacturers. Expression hemolysin genes hla, hlb, hlgC, hld detected...
It is difficult to study the intestinal damage induced by space radiation astronauts directly, and few prediction models exist. However, we can simulate it in patients with pelvic tumor radiotherapy (RT). Radiation-induced injury (RIII) common cancer who receieved abdominal RT. We dynamically analyzed gut microbiota metabolites alterations 17 cervical endometrial after In later developed grade 2 RIII, dysbiosis of were observed. Univariate analysis showed that Erysipelatoclostridium...
Surveillance systems revealed that the prevalence of vancomycin-resistant
With the rapid increase in number of implant operations, incidence bone infections has increased. Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make management even more challenging. Bone are mainly caused by S. require extensive surgical intervention long-term antibiotic therapy. The host autophagy response is critical to elimination infections. In this study, we demonstrate that a circular RNA (circRNA), circSyk, potential...
Methicillin-resistant Staphylococcus aureus (MRSA), is one of the most prevalent clinical pathogens isolated from hospital settings, and has increasingly identified in community settings. In China, SCCmecIII-ST239 strains are disseminated different geographic regions, accounting for > 75% all MRSA isolates some national studies. Here we characterized 150 non-duplicate collected February 2012 to May 2013 a tertiary Suzhou, Eastern explore molecular epidemiology. All were by spa typing, SCCmec...
Abstract Background The role of circular RNAs (circRNAs) and microRNAs (miRNAs) in osteosarcoma (OS) development has not been fully elucidated. Further, the contribution immune response to OS progression is well defined. However, it known that circRNAs miRNAs can serve as biomarkers for diagnosis, prognosis, therapy many cancers. Thus, aim this study was identify novel key serum diagnosis metastatic prediction by analysis cell infiltration associated RNA molecules. Methods Human...
Staphylococcus aureus (S. aureus) has the ability to invade human cortical bones and cause intracellular infections in osteoblasts, which may lead a long-term infection that is difficult eliminate. It critical identify underlying mechanisms of osteoblast response S. aureus. More recently, multiple circular RNA (circRNA) functions have been identified, including serving as protein scaffolds or miRNA sponges being translated into polypeptides. The role circRNAs play osteoblasts not, our...
To demonstrate the role of RpoE during later stage hyperosmotic stress in Salmonella.Expressions SPI-1 and SPI-2 under for 120 min were investigated by a microarray, invasion intracellular survival wild-type ΔrpoE strains compared. The global differential expression bacterial proteins between was examined after stress.SPI-1 repressed, defected strain. Thirteen bacterial-associated 11 secreted differed significantly strains.RpoE may promote regulating SPI-2.
Based on a hydrostatic check, preliminary quality control procedure was applied to the hourly surface air pressure (SAP) and sea level (SLP) data from 13 observation stations in Tianjin, China. The daily monthly series of two pressures were tested for homogeneity with RHtestsV5 software package corrected by using temperature as reference. results showed that 5 3 had significant breakpoints their SAP SLP data, respectively, mainly caused station relocation. Quantile matching adjustments both...
Salmonella enterica serovar Typhi ( S . Typhi) is a human-specific pathogen that causes typhoid fever. In this study, we constructed<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>Δ</mml:mi></mml:mrow></mml:math> ygaE mutant and microarray was performed to investigate the role of in regulation gene expression changes response hyperosmotic stress Typhi. qRT-PCR validate results. Our data indicated repressor gab operon as Escherichia coli E. ), though...
Sepsis is one of the diseases that can cause serious mortality. In E. coli, an inner membrane protein YgiM encoded by gene ygiM target eukaryotic peroxisome. Peroxisome a membrane-enclosed organelle associated with ROS metabolism and was reported to play key role in immune responses inflammation during development sepsis. Klebsiella pneumoniae (K. pneumoniae) important pathogens causing However, function vk055_4013 which highly homologous coli has not been demonstrated K. pneumoniae. this...
Abstract Background The surveillance system revealed that the prevalence of vancomycin-resistant Enterococcus faecium (VREfm) has increased. We aim to investigate epidemiological and genomic characteristics VREfm in China. Methods collected 20747 non-redundant E. isolates from inpatients across 19 hospitals six provinces between Jan 2018 June 2023. was confirmed by antimicrobial susceptibility testing. analyzed using changepoint package R. Genomic were explored whole-genome sequencing...
ABSTRACT Staphylococcus haemolyticus ( S. ) is a coagulase-negative that has become one of the primary causes nosocomial infection. After long period antibiotic use, developed multiple resistance phenotypes for macrolides and lincosamides. Herein, we evaluated four S . clinical isolates, which three had patterns reported previously. The fourth isolate was resistant to both erythromycin clindamycin in absence induction. This novel phenotype, known as constitutive...
Objective To discuss the cause and consequence of a radiological accident, where 6 staff members were suspected to be irradiated. Similar medical cases included by focusing on clinical manifestations, external radiation dose estimation, treatment. Methods Blood specimen was extracted from analyze peripheral blood lymphocyte chromosomal aberration dic+r micronucleus. Their personal histories taken, other auxiliary evaluations conducted. The physical obtained directly calculating...
Abstract Circular RNAs (circRNAs) play important roles in a variety of pathological functions. However, the potential functions and detailed mechanisms circRNAs osteosarcoma (OS) have not been fully elucidated. In this study, circRNA, micro RNA (miRNA), messenger (mRNA) expression profile human OS was investigated based on raw microarray data GSE140256, GSE65071 GSE16088 Gene Expression Omnibus (GEO) datasets, seven differentially-expressed (DEcircRNAs), 166 miRNAs (DEmiRNAs), 175 mRNAs...
Abstract Background: The potential functions of circular RNAs (circRNAs) and micro (miRNAs) in osteosarcoma (OS) have not been fully elucidated. Especially, the behavior mechanism immune responses OS development progression demonstrated. It was reported that circRNAs miRNAs can serve as biomarkers for diagnosis, prognosis, therapy many cancers. This study aimed to identify novel key serum diagnose predict metastasis based on analysis cell infiltration characteristics. Methods:...