A5033914791- Heart Rate Variability and Autonomic Control
- Multiple Sclerosis Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
- Cardiovascular Syncope and Autonomic Disorders
- Advanced Radiotherapy Techniques
- Atrial Fibrillation Management and Outcomes
- Sphingolipid Metabolism and Signaling
- Genetic Neurodegenerative Diseases
- Lung Cancer Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Urinary Bladder and Prostate Research
- Mitochondrial Function and Pathology
- Venous Thromboembolism Diagnosis and Management
- Medicinal Plants and Bioactive Compounds
- EEG and Brain-Computer Interfaces
- Head and Neck Cancer Studies
- Ubiquitin and proteasome pathways
- Cerebrovascular and Carotid Artery Diseases
- Hormonal and reproductive studies
- Vagus Nerve Stimulation Research
- Head and Neck Surgical Oncology
- Effects of Radiation Exposure
- Dermatology and Skin Diseases
Universitätsklinikum Erlangen
2019-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
University Hospital Regensburg
2024
Jining Medical University
2022-2023
Guangzhou Medical University
2014-2022
Nanjing Audit University
2022
Klinik und Poliklinik für Neurologie
2019-2021
Weifang People's Hospital
2021
Qinghai Normal University
2021
First Affiliated Hospital of Zhengzhou University
2013-2019
Gordon Holmes syndrome (GHS) is a rare Mendelian neurodegenerative disorder characterized by ataxia and hypogonadism. Recently, it was suggested that disordered ubiquitination underlies GHS though the discovery of exome mutations in E3 ligase RNF216 deubiquitinase OTUD4. We performed sequencing family with two three siblings afflicted hypogonadism identified homozygous mutation STUB1 (NM_005861) c.737C→T, p.Thr246Met, gene encodes protein CHIP (C-terminus HSC70-interacting protein). plays...
To investigate the aetiology, subsequent preventive strategies and outcomes of stroke despite anticoagulation in patients with atrial fibrillation (AF). We analysed consecutive AF an index imaging-proven ischaemic vitamin K-antagonist (VKA) or direct oral anticoagulant (DOAC) treatment across 11 centres. classified aetiology as: (i) competing mechanism other than AF-related cardioembolism; (ii) insufficient (non-adherence low activity measured drug-specific assays); or, (iii) cardioembolism...
Abstract Depression has become one of the most common mental illnesses in world. For better prediction and diagnosis, methods automatic depression recognition based on speech signal are constantly proposed updated, with a transition from early traditional hand‐crafted features to application architectures deep learning. This paper systematically precisely outlines prominent up‐to‐date research by intelligent processing so far. Furthermore, for acoustic feature extraction, algorithms...
Atrial fibrillation (AF) known before ischemic stroke (KAF) has been postulated to be an independent category with a recurrence risk higher than that of AF detected after (AFDAS). However, it is unknown whether this difference confounded by pre-existing anticoagulation, which most common in KAF and also indicates high risk.
After traumatic brain injury (TBI), central autonomic dysfunction might contribute to long-term increased mortality rates. Central depend on initial trauma severity. This study was performed evaluate differences in modulation at rest and upon standing between patients with a history of mild TBI (post-mild-TBI patients), moderate or severe (post-moderate-severe-TBI healthy controls. In 20 post-mild-TBI (6-78 months after TBI), age-matched post-moderate-severe-TBI (6-94 TBI) controls, we...
Patients with a history of mild TBI (post-mTBI-patients) have an unexplained increase in long-term mortality which might be related to central autonomic dysregulation (CAD). We investigated whether standardized baroreflex-loading, induced by Valsalva maneuver (VM), unveils CAD otherwise healthy post-mTBI-patients.In 29 persons (31.3 ± 12.2 years; 9 women) and 25 post-mTBI-patients (35.0 13.2 years, 7 women, 4-98 months post-injury), we monitored respiration (RESP), RR-intervals (RRI)...
Background and Purpose— The Age, Blood Pressure, Clinical Features, Duration, Diabetes plus Dual TIA (ABCD 3 -I) score is recommended to predict the risk of early stroke after transient ischemic attack. aim this study was validate predictive value ABCD -I compare accuracy 2 ) scores in a Chinese population. Methods— Data were prospectively collected from patients who had attack, as defined by World Health Organization time-based criteria. available within 7 days index outcome occurrence at...
Radio- and chemo-resistance represent major obstacles in the therapy of non-small-cell lung cancer (NSCLC) underlying molecular mechanisms are not known. In present study, during induction radio- or NSCLC cells, dynamic analyses revealed that decreased expression let-7 induced by irradiation cisplatin resulted increased its target gene LIN28, LIN28 then contributed to further inhibiting maturation biogenesis. Moreover, we showed down-regulation up-regulation promoted resistance regulating...
Cardio- and cerebrovascular events such as myocardial infarction (MI), stroke transient ischemic attack (TIA) are leading causes of death disability have also been associated with poor mental outcomes. In addition, cardio- may pose the risk experiencing a sudden traumatic occurrence symptoms during ictus thus contribute to high rates PTSD well subsequent depression anxiety. Moreover, MI, TIA survivors PTSD, depressive anxiety poorer health-related quality life (HRQoL) disease prognosis than...
Background The association between atherogenic dyslipidemia and stroke recurrence remains unclear, may be influenced by different subtypes of ischemic stroke. Aims We aimed to investigate whether contributed in patients those with certain Methods conducted a prospective hospital-based study enrolling acute Atherogenic was defined as high-density lipoprotein cholesterol <40 mg/dl triglycerides ≥200 mg/dl. Ischemic were classified according the Trial Org 10172 Acute Stroke Treatment...
Abstract Headache is very frequent in multiple sclerosis. However, the question whether headache just coincidental or may be secondary due to inflammatory cerebral sclerosis lesions yet clarified. This study intended evaluate distribution of lesion sites and potential presence specific clusters patients with comorbid using voxel-based symptom mapping (VLSM). Patients were prospectively identified included a university neurological center between 2017 2023. Only onset after first...
Early detection of skull base invasion in nasopharyngeal carcinoma (NPC) is crucial for correct staging, assessing treatment response and contouring the tumor target radiotherapy planning, as well improving patient's prognosis. To compare t
Cardiovascular autonomic dysfunction is common in multiple sclerosis (MS) and contributes significantly to disability. We hypothesized that cerebral MS-lesions specific areas of the central network might account for imbalance sympathetic parasympathetic cardiovascular modulation. Therefore, we used voxel-based lesion symptom mapping (VLSM) determine associations between MS-related sites. In 74 MS-patients (mean age 37.0 ± 10.5 years), recorded electrocardiographic RR-intervals systolic...
After mild traumatic brain injury (mTBI), patients have increased long-term mortality rates, persisting even beyond 13 years. Pathophysiology is unclear. Yet, central autonomic network dysfunction may contribute to cardiovascular dysregulation and mortality. Purely parasympathetic challenge by eyeball pressure stimulation (EP), might unveil subtle in post-mTBI patients. We investigated whether EP shows In 24 (34 ± 12 years; 5-86 months post-injury) 27 controls (30 11 years), we monitored...
In multiple sclerosis (MS) patients, Fingolimod may induce prolonged heart-rate slowing which might be caused by MS-related central autonomic lesions.To evaluate whether MS-patients with (> six hours) upon show cardiovascular-autonomic dysfunction before Fingolimod-initiation.Before Fingolimod-initiation, we recorded electrocardiographic RR-intervals (RRIs) and blood-pressure (BP) at rest, standing-up, during metronomic deep-breathing, Valsalva-maneuver, "sustained-handgrip-exercise" in 21...
Objective To investigate the safety and effectiveness of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) after recent stroke in patients with atrial fibrillation (AF) aged ≥85 years. Methods Individual patient data analysis from seven prospective cohorts. We compared DOAC VKA treatment among AF (<3 months) <85 Primary outcome was composite recurrent stroke, intracranial hemorrhage (ICH) all‐cause death. used simple, adjusted, weighted Cox regression to account for...
Patients with atrial fibrillation have a relevant risk for ischemic stroke despite the recommended use of direct oral anticoagulants (DOAC). The correlates functional DOAC plasma levels in clinical trials, but value their measurement community remains undetermined.We aim to investigate implications and prognostic level during steady state.In this observational cohort study among patients fibrillation, 397 individuals on secondary prevention were included between 2016 2020. measured state....
Stroke may compromise cardiovascular-autonomic modulation (CAM). The longitudinal post-stroke CAM alterations remain unclear as previous studies excluded patients with cardiovascular medication. This study evaluated whether dysfunction improves after several months in under typical clinical conditions, i.e., without excluding medication.In 82 ischemic stroke [33 women, 64.9 ± 8.9 years, NIHSS-scores 2 (interquartile range 1-5)], we the applications of medication before stroke, during...
The aims of this study were to evaluate the volume and dosimetric variations during IMRT for locally advanced NPC identify benefits a two-phase adaptive method. Twenty patients with having received treatme
In women with multiple sclerosis (MS), depression and sexual dysfunction (SD) are common. Whether SD promotes or vice versa remains unclear despite therapeutic relevance. Therefore, we aimed to assess whether more likely triggers versa.In 83 female MS patients 21 age-matched healthy women, assessed depression, using the Beck Depression Inventory-V (BDI-V), Female Sexual Function Index (FSFI). We diagnosed BDI-V-scores >35 FSFI scores < 26.55. divided into groups without SD, depression....
Atrial fibrillation (AF) in stroke patients can be classified as either "known AF" (KAF), defined AF confirmed before onset, or "AF detected after stroke" (AFDAS), diagnosed onset. While KAF is considered primarily cardiogenic, AFDAS includes with stroke-triggered neurogenic arrhythmias. This study aimed to investigate the clinical course of stroke, functional outcomes and value oral anticoagulation (OAC) for secondary prevention according subtype.Acute ischemic were consecutively enrolled...