A5000136889- Effects of Radiation Exposure
- MicroRNA in disease regulation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Oral health in cancer treatment
- Ubiquitin and proteasome pathways
- Speech Recognition and Synthesis
- Speech and Audio Processing
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Music and Audio Processing
- Nerve injury and regeneration
- DNA Repair Mechanisms
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Protein Degradation and Inhibitors
- Cancer, Stress, Anesthesia, and Immune Response
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Research and Treatments
Qingdao Center of Resource Chemistry and New Materials
2025
Second Affiliated Hospital of Soochow University
2015-2024
Soochow University
2015-2024
Dalian University of Technology
2021
First Affiliated Hospital of Anhui Medical University
2019-2020
Anhui Medical University
2019-2020
Suzhou Research Institute
2019
Southern Research Institute
2018
University of Alabama at Birmingham
2018
Institute of Acoustics
2011-2012
Radiation-induced intestinal injury (RIII) occurs during instances of intentional or accidental radiation exposure. However, there are few effective treatments available for the prevention mitigation RIII currently. (−)-Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, possesses potent antioxidant activity and has been shown to be ameliorating many oxidative stress-related diseases. The therapeutic effects mechanism EGCG on have not yet determined. In present study, we...
The intestine is prone to radiation damage in patients undergoing radiotherapy for pelvic tumors. However, there are currently no effective drugs available the prevention or treatment of radiation-induced enteropathy (RIE). In this study, we aimed at investigating impact indole-3-carboxaldehyde (I3A) derived from intestinal microbiota on RIE. Intestinal organoids were isolated and cultivated screening radioprotective tryptophan metabolites. A RIE model was established using 13 Gy...
The acute radiation-induced intestinal injury (RIII) has raised much concerns and is influenced by non-cytocidal radiation effects including the perturbations in gut microbiota. Although a number of studies have reported alteration microbiota following radiation, little known about its dynamic variation progression RIII. In this study, mouse model were treated with total body irradiation (TBI) 0, 4, 8 12 Gy, tissues fecal samples collected at 6 h, 3.5 d 7 post radiation. We found that...
PurposeRadiation-induced intestinal injury (RIII) commonly occur during abdominal-pelvic cancer radiation therapy; however, no effective prophylactic or therapeutic agents are available to manage RIII currently. This study aimed clarify the potential of probiotic consortium supplementation in alleviating RIII.Methods and MaterialsMale C57BL/6J mice were orally administered a mixture comprising Bifidobacterium longum BL21, Lactobacillus paracasei LC86, plantarum Lp90 for 30 days before...
This study investigated whether exosomal microRNA-7 (miR-7) mediates lung bystander autophagy after focal brain irradiation in mice. After 10 Gy or sham of mice brains, tissues were extracted for the detection markers by immunohistochemistry, western blotting, and quantitative real-time reverse transcription PCR (qRT-PCR), meanwhile brains dissociated, neuron/astrocyte/microglia/oligodendrocyte isolated, miR-7 expression each population detected, respectively. A dual-luciferase reporter...
Abstract POLRMT (RNA polymerase mitochondrial) is responsible for the transcription of mitochondrial genome encoding key components oxidative phosphorylation. This process important cancer cell growth. The current study tested expression and potential functions in non-small lung (NSCLC). TCGA cohorts results from local tissues showed that overexpressed human tissues. In both primary NSCLC cells A549 cells, silencing (by targeted lentiviral shRNAs) or knockout (through CRSIPR/Cas9 gene...
It is difficult to study the intestinal damage induced by space radiation astronauts directly, and few prediction models exist. However, we can simulate it in patients with pelvic tumor radiotherapy (RT). Radiation-induced injury (RIII) common cancer who receieved abdominal RT. We dynamically analyzed gut microbiota metabolites alterations 17 cervical endometrial after In later developed grade 2 RIII, dysbiosis of were observed. Univariate analysis showed that Erysipelatoclostridium...
This article begins by discussing the important impact of gut microbiome on obesity, emphasizing how changes in microbial diversity and composition can influence fat storage, energy extraction, metabolic health. It first outlines connection between microbes key obesity-related mechanisms such as accumulation, insulin resistance, systemic inflammation. Next, external elements like nutrition, medications, lifestyle, genetics that and, consequently, obesity outcomes are examined. Afterward,...
The high radiosensitivity of the intestinal epithelium limits outcomes radiotherapy against abdominal malignancies, which results in poor prognosis. Currently, no effective prophylactic or therapeutic strategy is available to mitigate radiation toxicity intestine. Our previous study revealed that green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) attenuates radiation-induced injury (RIII). aim present was determine effect EGCG on flora irradiated mice. administration reduced mucosal...
Ninjurin2 (Ninj2) is an adhesion protein expressed in neurons and glial cells.The current study tested its expression potential functions human glioma.We show that Ninj2 mRNA levels are significantly upregulated glioma cells tissues.In established primary cells, shRNA or knockout (by CRISPR/Cas9 gene editing) potently inhibited cell survival, growth, proliferation, migration invasion, while inducing apoptosis activation.Contrarily, ectopic overexpression of promoted progression vitro.In...
Anaplastic thyroid cancer (ATC) is an aggressive with poor clinical prognosis. However, mechanisms driving ATC aggressiveness not well known. Components of the DNA damage response (DDR) are frequently found mutated or aberrantly expressed in ATC. The goal this study to establish functional link between histone acetyltransferase lysine (K) 5 (KAT5, a critical DDR protein) and invasiveness using clinical, vitro vivo models. We analyzed expression KAT5 by immunohistochemistry assessed its...
Although existing fully-supervised defocus blur detection (DBD) models significantly improve performance, training such deep requires abundant pixel-level manual annotation, which is highly time-consuming and error-prone. Addressing this issue, paper makes an effort to train a DBD model without using any annotation. The core insight that region/focused clear area can be arbitrarily pasted given realistic full blurred image/full image affecting the judgment of image. Specifically, we...
Cisplatin is the most commonly used antitumor drug in chemotherapy of a variety malignancies. However, severe side effects and resistance limit its clinical application. The aim this study was to develop PLGA-based cisplatin-loaded implants evaluate efficacy continuous intratumoral with implants. were prepared by direct compression method characterized regarding content, micromorphology, vitro vivo release profiles. Furthermore, activity conducted sarcoma 180 tumor-bearing mice. SEM images...
Background Lower-grade glioma (LGG) is a type of central nervous system tumor that includes WHO grade II and III gliomas. Despite developments in medical science technology the availability several treatment options, management LGG warrants further research. Surgical for poses challenge owing to its often inaccessible locations brain. Although radiation therapy (RT) most important approach this condition offers more advantages compared surgery chemotherapy, it associated with certain...
Abstract The nuclear receptor-binding SET domain 3 (NSD3) catalyzes methylation of histone H3 at lysine 36 (H3K36), and promotes malignant transformation progression human cancer. Its expression, potential functions underlying mechanisms in pancreatic cancer are studied. Bioinformatics studies results from local tissues show that NSD3 is upregulated tissues, which correlated with poor overall survival. In primary established cells, silencing (by shRNAs) or CRISPR/Cas9-induced knockout...
Abstract Bromodomain testis-specific factor (BRDT) is a member of the bromodomain and extra-terminal (BET) family proteins. Its expression potential functions in ovarian cancer were examined. We show that BRDT overexpressed human tissues established (CaOV3)/primary cells. However, its low epithelial Significantly, shRNA-induced silencing or CRISPR/Cas9-mediated knockout inhibited cell growth, viability, proliferation migration, induced significant apoptosis activation. Conversely, exogenous...
We have previously shown that Gαi3 is elevated in human glioma, mediating Akt activation and cancer cell proliferation. Here, we imply could also be important for irradiation resistance. In A172 glioma cells, knockdown (by targeted shRNAs) or dominant-negative mutation significantly potentiated irradiation-induced apoptosis. Reversely, forced over-expression of wild-type constitutively-active inhibited Irradiation cells induced translocation to nuclei association with local protein...
Abstract Bromodomain-containing protein 4 (BRD4) is a potential therapeutic target of skin squamous cell carcinoma (SCC). I-BET726 novel BRD4 inhibitor. Its effect in SCC cells was tested the present study. We show that potently inhibited survival, proliferation, cycle progression, and migration established (A431/SCC-9/SCC-12/SCC-13 lines) primary human cells. induced significant apoptosis activation It more efficient inhibiting than known inhibitors (JQ1, CPI203, AZD5153). not only...