A5061543595- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Thyroid and Parathyroid Surgery
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- BRCA gene mutations in cancer
- Pancreatic and Hepatic Oncology Research
- Head and Neck Anomalies
- interferon and immune responses
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Biomarkers in Disease Mechanisms
- Cancer Mechanisms and Therapy
- Neuroendocrine Tumor Research Advances
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Sun Yat-sen University
2010-2025
Nanjing Medical University
2025
Sun Yat-sen Memorial Hospital
2012-2025
Nankai University
2023-2025
Second Hospital of Shandong University
2025
Fujian Agriculture and Forestry University
2025
Xi'an Technological University
2025
Tianjin People's Hospital
2021-2024
Xiangya Hospital Central South University
2023-2024
Selpercatinib, a highly selective, potent RET inhibitor, has shown efficacy in advanced RET-mutant medullary thyroid cancer phase 1–2 trial, but its as compared with approved multikinase inhibitors is unclear. Download PDF of the Research Summary. We conducted 3, randomized trial comparing selpercatinib first-line therapy physician's choice cabozantinib or vandetanib (control group). Eligible patients had progressive disease documented within 14 months before enrollment. The primary end...
Background: Cancer stem cells (CSCs) are highly tumorigenic, chemotherapy-resistant, tumor growth-sustaining, and implicated in recurrence.Previous studies have shown that lysine-specific histone demethylase 1A (KDM1A) is expressed several human malignancies CSCs.However, the role of KDM1A CSCs therapeutic potential inhibitors for treatment advanced thyroid cancer poorly understood.Methods: Firstly, was identified as an important epigenetic modifier maintained stemness through a mini...
Significance Chronic wounds in diabetic patients are a devastating complication of diabetes that can lead to amputations or even death. Our work db/db mice shows matrix metalloproteinase (MMP)-9 contributes delayed impaired wound healing and MMP-8 is involved repairing the wound. A combination selective inhibitor MMP-9 (a small molecule) exogenously applied active recombinant (an enzyme) accelerates mice.
The incidence of papillary thyroid carcinoma (PTC) has exponentially increased in recent years. Papillary microcarcinoma (PTMC) accounts for the majority reported cases PTC. debates and crucial issues PTMC management have received researchers' attention. To further improve
The purposes of this study were to identify risk factors for cervical lymph node metastasis and examine the association between BRAFV600E status clinical features in papillary thyroid microcarcinoma (PTMC).A total 1,587 patients with PTMC, treated Tianjin Medical University Cancer Institute Hospital from January 2011 March 2013, underwent retrospective analysis. We reviewed analyzed including results, pathology records, ultrasound status.Multivariate logistic regression analyses demonstrated...
Papillary thyroid carcinoma (PTC) is one of the most common kinds endocrine-related cancer and has a heterogeneous prognosis. Metabolic reprogramming hallmarks cancers. Aberrant glucose metabolism associated with malignant biological behavior. However, functions mechanisms genes in PTC are not fully understood. Thus, data from The Cancer Genome Atlas database were analyzed, lactate dehydrogenase A (LDHA) was determined to be potential novel diagnostic therapeutic target for PTCs. research...
Abstract Jasmonic acid (JA) is a key regulator of plant defense responses. Although the transcription factor MYC2, master JA signaling pathway, orchestrates hierarchical transcriptional cascade that regulates responses, only few regulators involved in this have been described. Here, we identified basic helix‐loop‐helix (bHLH) gene tomato ( Solanum lycopersicum ), METHYL JASMONATE MeJA ) ‐INDUCED GENE SlJIG expression which was strongly induced by treatment. Genetic and molecular biology...
Abstract Initiation and progression of leaf senescence are triggered by various environmental stressors phytohormones. Jasmonic acid (JA) darkness accelerate in plants. However, the mechanisms that integrate these two factors to initiate regulate have not been identified. Here, we report a transcriptional regulatory module centred on novel tomato WRKY transcription factor, SlWRKY37, responsible for both JA- dark-induced senescence. The expression together with SlMYC2, encoding master factor...
Central lymph node metastasis (CLNM) is a predictor of poor prognosis for papillary thyroid carcinoma (PTC) patients. The options surgeon operation or follow-up depend on the state CLNM while accurate prediction challenge radiologists. present study aimed to develop and validate an effective preoperative nomogram combining deep learning, clinical characteristics ultrasound features predicting CLNM.In this study, 3359 PTC patients who had undergone total thyroidectomy lobectomy from two...
BackgroundThe outcome of patients with resectable mucosal melanoma is poor. Toripalimab combined axitinib has shown impressive results in metastatic an objective response rate 48.3% and a median progression free survival 7.5 months phase 1b trial. It was hypothesized that this combination administered the neoadjuvant setting might induce pathologic melanoma, so we conducted trial.Patients methodsThis single-arm II trial enrolled melanoma. Patients received toripalimab 3 mg/kg Q2W plus 5 mg...
The incidence of primary liver cancer is increasing year by year, with environmental factors playing a non-negligible role. At present, many studies are still disputing whether air pollution associated incidence, and it difficult to draw causal inferences. Therefore, in this study, we used two-sample Mendelian randomization (MR) assess the relationship between (including PM2.5, PM2.5-10, PM10, nitrogen dioxide oxides) risk its related biomarkers (Alpha-fetoprotein, Osteopontin, Glypican-3...
There is no effective treatment for patients with poorly differentiated papillary thyroid cancer or anaplastic (ATC). Anlotinib, a multi-kinase inhibitor, has already shown antitumor effects in various types of carcinoma phase I clinical trial. In this study, we aimed to better understand the effect and efficacy anlotinib against cells vitro vivo. We found that inhibits cell viability ATC lines, likely due abnormal spindle assembly, G2/M arrest, activation TP53 upon treatment. Moreover,...
Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune functions play vital role in ACS development; however, whether epigenetic modulation contributes to the regulation blood immune cells this disease has not been investigated.We conducted an epigenome-wide analysis with circulating identify differentially methylated genes ACS.We examined genome-wide methylation whole 102 patients and 101 controls using HumanMethylation450 array, externally replicated significant...
Hashimoto's thyroiditis (HT) is the main cause of hypothyroidism. We develop a deep learning model called HTNet for diagnosis HT by training on 106,513 thyroid ultrasound images from 17,934 patients and test its performance 5051 2 datasets static 1 dataset video data. achieves an area under receiver operating curve (AUC) 0.905 (95% CI: 0.894 to 0.915), 0.888 (0.836-0.939) 0.895 (0.862-0.927). exceeds radiologists' accuracy (83.2% versus 79.8%; binomial test, p < 0.001) sensitivity (82.6%...
Objective This study aimed to evaluate the effectiveness and safety of carbon nanoparticles - guided lymph node dissection during thyroidectomy in patients with papillary thyroid cancer(PTC). Methods Clinical trials consisted two subgroups: unilateral lobectomy (UL; n=283) total (TT; n=286). From each subgroup, were randomly assigned groups: nanoparticle group control group. Primary endpoints included parathyroid hormone (PTH) levels, number nodes (LNs) detected, tiny recognition retention...