A5036148294- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Coastal and Marine Dynamics
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Tracheal and airway disorders
- Head and Neck Anomalies
- Coastal wetland ecosystem dynamics
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Salivary Gland Tumors Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Geological formations and processes
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
- Immune Response and Inflammation
- Hormonal Regulation and Hypertension
- Ear and Head Tumors
- Tannin, Tannase and Anticancer Activities
- Proteoglycans and glycosaminoglycans research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ultrasound and Hyperthermia Applications
Tianjin Medical University Cancer Institute and Hospital
2012-2023
Center for Cancer Research
2019
Tianjin Medical University
2007-2017
Ningxia Medical University
2011
The incidence of papillary thyroid microcarcinoma (PTMC) has been increasing globally in the past few decades. PTMC does not have a distinctive morphology that results differences biological behavior. aim this study was to classify PTMCs according morphological features and explore relationship with clinicopathological characteristics. Additionally, we sought evaluate whether different variants can be an independent predictor for lymph mode metastasis when considering other risk factors....
DNA methylation is a kind of crucial epigenetic marker orchestrating gene expression, molecular function, and cellular phenotype. However, manipulating the status specific genes remains challenging. Here, clustered regularly interspaced palindromic repeats-Cas9-based near-infrared upconversion-activated editing system (CNAMS) was designed for optogenetic methylation. The fusion proteins photosensitive CRY2PHR, catalytic domain DNMT3A or TET1, CIBN catalytically inactive Cas9 (dCas9) were...
NUCB2, a novel multifunctional protein containing several functional domains, was newly found to play important roles in many cancers, but its role papillary thyroid cancer (PTC) is not well investigated. Therefore, our study performed explore the functions of NUCB2 PTC.NUCB2 level analyzed by immunohistochemistry. Data analyses were made performing chi-squared test. Quantitative reverse-transcription PCR, Western blot, colony formation, MTT, and transwell invasion assays test expression...
Abstract Objectives/Hypothesis: Head and neck paragangliomas (PGLs) are rare frequently associated with germline mutations of the succinate dehydrogenase (SDH) genes, especially for familial cases. The purpose study was to explore genetic clinical characteristics head PGLs in a Chinese population. Study Design: Retrospective review. Methods: One hundred thirty‐two patients who had undergone resection between 1975 2010 were identified. Clinical outcomes reviewed. Analysis SDH genes performed...
Thyroid cancer is the most common endocrine malignant tumor. The accurate risk stratification and prognosis assessment particularly important for patients with thyroid cancer, which can reduce tumor recurrence rate, morbidity, mortality effectively. DNA methylation one of widely studied epigenetic modifications. Many studies have shown that 5hmC-mediated demethylation played an role in tumors. hydroxylation 5mC catalyzed by ten-eleven translocation dioxygenase (TET). In this study, we first...
A formula for the hindered settling velocity of fluid mudlike suspensions is determined based on Darcy's equation pore water seepage in a consolidating particulate matrix, which specific permeability obtained by assuming interstitial capillary flow to be described Hagen-Poiseuille equation. Sediment-specific parameters are evaluated from series experiments initially suspended mixtures dense fine-grained sediments and at different salinities were allowed settle. From results it concluded that...
Hypocalcemia is the most common complication that challenges surgeons performing total thyroidectomy. Conventional postoperative calcium and calcitriol supplement has been reportedly effective; however, a time lag reported before taking effect. Therefore, role of preoperative strategy yet to be determined. In this prospective, randomized, open-label, parallel-controlled phase II clinical study (registration number: ChiCTR2200059815), short-term administration was proposed in 210 patients...
BRAF V600E is the most common genetic alteration in thyroid cancer and indicative of a relatively poor prognosis. A selective inhibitor has been proposed as novel treatment for patients with exhibiting mutations. However, this demonstrated limited therapeutic effect. In present study, possible adaptive mechanisms resistance cells to specific inhibitor, PLX4032, were investigated. MTT assays performed determine anti‑proliferative efficiencies half maximal inhibitory concentration (IC50)...
Mechanisms that contribute to the modulation of release flux conservative constituents from bottom mud by water waves have been investigated. Laboratory flume tests were carried out initially inoculating fluid‐like clayey muds with dyes used as generic constituent surrogates. For each combination dye and mud, dissolved particle‐bound fluxes determined functions wave properties numerically modeling sediment transport. In absence entrainment in interfacial diffusive sublayer is mainly governed...
Objective To analyze the clinical and pathological features of follicular variant papillary thyroid carcinoma (FVPTC).Methods Clinical data 131 FVPTC patients diagnosed treated between January 2006 June 2012 were retrospectively analyzed.Results Of patients,the median age at diagnosis was 45 years 74.0％ female.Pathologically 29％ (38 patients) encapsulated,and 71％ (93 nonencapsulated.Compared with classical (CPTC),FVPTC more likely to have lower ultrasound diagnostic accuracy rate,frozen...