A5100997615- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Sleep and related disorders
- Carcinogens and Genotoxicity Assessment
- COVID-19 and Mental Health
- Sleep and Work-Related Fatigue
- Nutritional Studies and Diet
- Telomeres, Telomerase, and Senescence
- Effects and risks of endocrine disrupting chemicals
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- COVID-19 Pandemic Impacts
- MicroRNA in disease regulation
- Nutrition and Health in Aging
- Cancer Risks and Factors
- COVID-19 epidemiological studies
- Climate Change and Health Impacts
- Cardiovascular Health and Risk Factors
- Gout, Hyperuricemia, Uric Acid
- RNA modifications and cancer
Guangzhou Medical University
2022-2025
Huazhong University of Science and Technology
2015-2022
State Key Laboratory of Respiratory Disease
2022
Zhengzhou University
2019
Dongfeng General Hospital
2019
China National Pharmaceutical Group Corporation (China)
2019
Hubei University of Medicine
2019
Tongji Hospital
2018
To investigate the associations of sleep duration, midday napping, quality, and change in duration with risk incident stroke subtypes.Among 31,750 participants aged 61.7 years on average at baseline from Dongfeng-Tongji cohort, we used Cox regression models to estimate hazard ratios (HRs) 95% confidence intervals (CIs) for stroke.Compared sleeping 7 <8 hours/night, those reporting longer (≥9 hours/night) had a greater total (hazard ratio [HR] 1.23; interval [CI] 1.07-1.41), while shorter (<6...
Background: Our previous study has demonstrated an oncogenic role of PIWI-interacting RNA-54265 (piR-54265) in colorectal cancer (CRC). Here, we investigate whether it can be a blood biomarker for population screening and clinical applications. Methods: Serum piR-54265 levels were determined by digital PCR method 209 cancer-free healthy controls, 725 patients with CRC, 1303 other types digestive 192 benign tumors. A prospective case-control analysis was conducted to assess the predictive...
Previous studies have shown that inflammatory and antioxidant dietary patterns can modify the risk of COPD, yet few examined association these diets with its early signs (PRISm), potential role metabolic disorders remains to be elucidated.
Recently studies have demonstrated that the long non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) may participate in development and progression of cancer. In this study, we hypothesized genetic variant lncRNA affect prognosis cancer patients.We conducted a follow-up study for 538 patients with non-small cell carcinoma (NSCLC), including 140 early-staged (stage I II) 398 advanced staged III IV) patients. The rs3200401 MALAT1 was then genotyped among...
Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune functions play vital role in ACS development; however, whether epigenetic modulation contributes to the regulation blood immune cells this disease has not been investigated.We conducted an epigenome-wide analysis with circulating identify differentially methylated genes ACS.We examined genome-wide methylation whole 102 patients and 101 controls using HumanMethylation450 array, externally replicated significant...
Smoking is a risk factor for many human diseases. DNA methylation has been related to smoking, but genome-wide data smoking in Chinese populations limited.We aimed investigate epigenome-wide relation population.We measured the levels at > 485,000 CpG sites (CpGs) from leukocytes using array and conducted meta-analysis of total 596 participants. We further evaluated associations smoking-related CpGs with internal polycyclic aromatic hydrocarbon (PAH) biomarkers their correlations expression...
Background: Aging is related to an increased risk of morbidity and mortality affected by environmental factors. Exposure polycyclic aromatic hydrocarbons (PAHs) associated with adverse health outcomes; but the association such exposure DNA methylation aging, a novel aging marker, unclear. Objectives: Our aim was investigate PAH aging. Methods: We trained validated age predictor suitable for Chinese populations using whole blood data in 989 160 Caucasians. defined two indicators: Δage, as...
Essential metals play important roles in the carcinogenic process. However, seldom longitudinal investigations have evaluated their lung cancer development. We aimed to investigate associations between multiple essential and incidence explore potential mechanisms. A nested case-control study of 440 incident cases 1:3 frequency matched 1320 healthy controls from Dongfeng-Tongji Cohort was conducted. The baseline plasma concentrations 11 (cobalt, copper, iron, manganese, molybdenum, rubidium,...
Abstract Systemic immune-inflammation index (SII) emerged as a biomarker of chronic inflammation and an independent prognostic factor for many cancers. We aimed to investigate the associations SII level with total cause-specific mortality risks in general populations, potential modification effects lifestyle-related factors on above associations. In this study, we included 30,521 subjects from Dongfeng-Tongji (DFTJ) cohort 25,761 National Health Nutrition Examination Survey (NHANES)...
Healthcare workers (HCWs) are at the forefront of fighting against COVID-19 pandemic. However, they high risk acquiring pathogen from infected patients and transmitting to other HCWs. We aimed investigate factors for nosocomial infection among HCWs in a non-COVID-19 hospital yard. Retrospective data collection on demographics, lifestyles, contact status with subjects 118 (including 12 HCWs) Union Hospital Wuhan, China. Sleep quality working pressure were evaluated by Pittsburgh Quality Index...
Early life bone accumulation, which predicts future fragility fracture risk, is intimately associated with sex hormones. N, N-diethyl-3-methylbenzamide (DEET) the primary and most effective active ingredient widely used globally, especially among children adolescents. However, effects of DEET on hormones mass remain unclear. We aimed to explore adverse exposure elucidate potential mediating roles in This cross-sectional study analyzed 864 adolescents from NHANES 2013-2016. Urinary...
ABSTRACT Background There had been a preliminary occurrence of human-to-human transmissions between healthcare workers (HCWs), but risk factors in the susceptibility for COVID-19, and infection patterns among HCWs have largely remained unknown. Methods Retrospective data collection on demographics, lifestyles, contact status with infected subjects 118 (include 12 COVID-19 HCWs) from single-center. Sleep quality working pressure were evaluated by Pittsburgh Quality Index (PSQI) The Nurse...
Observational epidemiological studies have reported the associations of high body mass index (BMI) with elevated serum uric acid (UA) level and increased risk postmenopausal breast cancer. However, whether UA is causally induced by BMI functioned in BMI-breast cancer relationship remains unclear.To elucidate causality direction between UA, bidirectional Mendelian randomization (MR) analyses were performed using summarized data from largest Asian genome-wide association (GWAS) carried out...
Essential metals play important roles in maintaining cellular homeostasis, but the effects of their interaction with environmental pollutants are still not very well-known human subjects. The aim this study was to evaluate essential and interactions polycyclic aromatic hydrocarbons (PAHs) on chromosome damage, an early carcinogenic event. A total 1245 male workers were included levels 11 urinary metals, 12 PAH metabolites, plasma concentrations...
Thallium (Tl) is a cumulative high toxicant in the environment, but few longitudinal studies have investigated respiratory impairment of Tl exposure.This study aimed to evaluate effect and its interaction with smoking on lung function decline, explore potential mechanisms.The baseline follow-up functions were measured from prospective cohort 1243 workers, who followed 2010 2014. Their urinary levels determined. We also plasma C-reactive protein (CRP) 8-iso-prostaglandin-F2α (8-iso-PGF2α)...
Circulating white blood cell (WBC) counts have been related to lung function impairment, but causal relationship was not established. We aimed evaluate independent effects and relationships of WBC subtypes with function.The 19,159 participants from NHANES 2011-2012 (n = 3570), coke-oven workers (COW, n 1762) Dongfeng-Tongji (DFTJ, 13,827) cohorts were included in the observational studies. The associations between circulating prebronchodilator evaluated by linear regression models LASSO used...
Whether adopting healthy lifestyles and maintaining moderate levels of essential metals could attenuate the reduction heart rate variability (HRV) related to polycyclic aromatic hydrocarbons (PAHs) exposure are largely unknown. In this study, we measured urinary PAHs as well HRV, constructed a lifestyle score in 1267 coke oven workers. Linear regression models were used explore association with interaction analysis was performed investigate potential between score, metals, on HRV. Mean age...