A5017350288- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Cardiac Valve Diseases and Treatments
- RNA regulation and disease
- Aortic Thrombus and Embolism
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
- Fault Detection and Control Systems
- Machine Learning in Bioinformatics
- Forest ecology and management
- Plant-Microbe Interactions and Immunity
- HVDC Systems and Fault Protection
- Antiplatelet Therapy and Cardiovascular Diseases
- Esophageal and GI Pathology
- Tree Root and Stability Studies
- Wood Treatment and Properties
- Cancer, Hypoxia, and Metabolism
Heidelberg University
2024
University Hospital Heidelberg
2024
Sun Yat-sen University Cancer Center
2020-2023
Sun Yat-sen University
2020-2023
Guangdong Academy of Forestry
2022-2023
State Key Laboratory of Oncology in South China
2020-2023
Southern Medical University
2017-2018
Nanfang Hospital
2017-2018
Sinopec (China)
2017
Abstract 5-Methylcytosine (m 5 C) is a posttranscriptional RNA modification participating in many critical bioprocesses, but its functions human cancer remain unclear. Here, by detecting the transcriptome-wide m C profiling esophageal squamous cell carcinoma (ESCC), we showed increased methylation ESCC tumors due to overexpressed methyltransferase NSUN2. Aberrant expression of NSUN2 was positively regulated E2F Transcription Factor 1 (E2F1). High levels predicted poor survival patients....
Background: Our previous study has demonstrated an oncogenic role of PIWI-interacting RNA-54265 (piR-54265) in colorectal cancer (CRC). Here, we investigate whether it can be a blood biomarker for population screening and clinical applications. Methods: Serum piR-54265 levels were determined by digital PCR method 209 cancer-free healthy controls, 725 patients with CRC, 1303 other types digestive 192 benign tumors. A prospective case-control analysis was conducted to assess the predictive...
Pseudogenes may play important roles in cancer. Here, we explore the mechanism and function of a pseudogene WTAPP1 progress pancreatic ductal adenocarcinoma (PDAC). RNA was significantly elevated PDAC associated with poor prognosis patients. Overexpression promoted proliferation invasiveness vitro vivo. Mechanistically, N6-methyladenosine (m6A) modification stabilized via CCHC-type zinc finger nucleic-acid binding protein (CNBP), resulting increased levels cells. Excessive bound its...
The tumorigenic mechanism for pancreatic ductal adenocarcinoma (PDAC) is not clear, although chronic inflammation implicated. Here, we identified an inflammatory cytokine–regulated transfer RNA–derived (tRNA-derived) fragment, tRF-21-VBY9PYKHD (tRF-21), as a tumor suppressor in PDAC progression. We found that the biogenesis of tRF-21 could be inhibited by leukemia inhibitory factor and IL-6 via splicing SRSF5. Reduced promoted AKT2/1-mediated heterogeneous nuclear ribonucleoprotein L (hnRNP...
Abstract The molecular mechanism underlying pancreatic ductal adenocarcinoma (PDAC) malignancy remains unclear. Here, we characterize a long intergenic non-coding RNA LINC00842 that plays role in PDAC progression. expression is upregulated and induced by high concentration of glucose via transcription factor YY1. binds to prevents acetylated PGC-1α from deacetylation deacetylase SIRT1 form PGC-1α, an important co-factor regulating cellular metabolism. overexpression causes metabolic switch...
Thiol groups on cysteines can undergo multiple post-translational modifications (PTMs), acting as a molecular switch to maintain redox homeostasis and regulating series of cell signaling transductions. Identification sophistical protein cysteine is crucial for dissecting its underlying regulatory mechanism. Instead time-consuming labor-intensive experimental method, various computational methods have attracted intense research interest due their convenience low cost. Here, we developed the...
N6-methyladenosine (m6A) is the most prevalent RNA modification, and effect of its dysregulation on esophageal squamous cell carcinoma (ESCC) development remains unclear. Here, by performing transcriptome-wide m6A sequencing in 16 ESCC tissue samples, we identified key roles TNFRSF1A (also known as TNFR1)-mediated MAPK NF-κB activation ESCC. Mechanistically, a functional protein involved methylation, ATXN2, that augments translation binding to m6A-modified mRNA. Upregulation level, vital...
Abstract In recent years, long noncoding RNAs (lncRNAs) have been demonstrated to be important tumor‐associated regulatory factors. LncRNA growth arrest‐specific transcript 5 (Gas5) acts as an anti‐oncogene in most cancers. Whether Gas5 oncogene or hepatocellular carcinoma (HCC) remains unclear. the present study, expression and role of HCC were investigated vitro vivo. Lower levels determined tissues cells by quantitative reverse transcription‐polymerase chain reaction. Overexpressed Gas...
Falcataria falcata is an exotic tree species that was imported to southern China around 1940 and has been widely planted in the Guangdong province of China. Using 16S rRNA amplicon sequencing approach, we investigated composition bacterial endophytes root nodules naturally grown F. elucidated core endophyte group. Across all samples, there were 575 genera 29 phyla. Proteobacteria accounted for 42–90% relative abundance regions. Notably, Bradyrhizobium, Paucibacter, Rhizobium, Mesorhizobium...
Deep learning has been successfully applied into pattern recognition due to its deep architecture and effective unsupervised learning, belief network (DBN) is a popular model based on technique. In this paper, DBN identification partial least square regression (PLSR), named PLSR-DBN, proposed for nonlinear system identification. order improve the accuracy, PLSR introduced supervised fine-tuning of elimate overfitting local minimum resulted from gradients-based contrastive divergence (CD)...
Circular RNAs (circRNAs) are involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC). This study aimed to explore mechanisms aberrant expression and functions circ_0006168 ESCC. In this study, real-time qPCR fluorescence situ hybridization (FISH) adopted estimate localization cancer tissues cells. Methylated RNA immunoprecipitation (MeRIP) was performed detect N
With the growing demand for high-quality timber, selection processes both growth and wood properties are needed multi-trait breeding programs in Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.). The present study examined variation correlation of (tree height, diameter at breast stem volume, crown-width) (wood basic density, hygroscopicity, heart-wood ratio) traits 201 parents, aiming to select better parents future improvement. results showed that significant differences (p < 0.01)...
In this study, we aimed to expand the current miRNA data bank of Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) regarding its potential value for further genetic and genomic use in species. High-throughput small RNA sequencing successfully captured 140 miRNAs from a selfing family harboring vigor depressed progeny. Strikingly, 75.7% (n = 106) these have not been documented previously, most 105) them belong novel set with 6858 putative target genes. The new datasets were then integrated...
<div>Abstract<p>Pseudogenes may play important roles in cancer. Here, we explore the mechanism and function of a pseudogene <i>WTAPP1</i> progress pancreatic ductal adenocarcinoma (PDAC). RNA was significantly elevated PDAC associated with poor prognosis patients. Overexpression promoted proliferation invasiveness <i>in vitro</i> vivo</i>. Mechanistically, <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A)...
<div>Abstract<p>Pseudogenes may play important roles in cancer. Here, we explore the mechanism and function of a pseudogene <i>WTAPP1</i> progress pancreatic ductal adenocarcinoma (PDAC). RNA was significantly elevated PDAC associated with poor prognosis patients. Overexpression promoted proliferation invasiveness <i>in vitro</i> vivo</i>. Mechanistically, <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A)...
<p>Supplementary Materials and Methods</p>
<p>Clinical information for patients with IHC</p>
<p>Supplementary Materials and Methods</p>
<p>WTAPP1 full length RNA pull down with mass spectrum</p>
<p>Clinical information for patients with IHC</p>