A5101930662- Skin Protection and Aging
- Photodynamic Therapy Research Studies
- interferon and immune responses
- RNA modifications and cancer
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Advanced Fluorescence Microscopy Techniques
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Water Resources and Sustainability
- Plant Molecular Biology Research
- Water resources management and optimization
- Plant Reproductive Biology
- melanin and skin pigmentation
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Soil Geostatistics and Mapping
- Water-Energy-Food Nexus Studies
- Photochromic and Fluorescence Chemistry
- Morinda citrifolia extract uses
- Photoreceptor and optogenetics research
- Helminth infection and control
- Water Resources and Management
- Plant Gene Expression Analysis
Guangzhou University of Chinese Medicine
2021-2025
Southern University of Science and Technology
2025
Nanjing Forestry University
2024
Shanghai University of Traditional Chinese Medicine
2024
Guangxi University
2024
South China Agricultural University
2024
Shanghai Institute of Nutrition and Health
2023
University of Chinese Academy of Sciences
2023
Anhui Science and Technology University
2023
Anhui University of Science and Technology
2023
Pseudogenes may play important roles in cancer. Here, we explore the mechanism and function of a pseudogene WTAPP1 progress pancreatic ductal adenocarcinoma (PDAC). RNA was significantly elevated PDAC associated with poor prognosis patients. Overexpression promoted proliferation invasiveness vitro vivo. Mechanistically, N6-methyladenosine (m6A) modification stabilized via CCHC-type zinc finger nucleic-acid binding protein (CNBP), resulting increased levels cells. Excessive bound its...
The human ISWI-containing factor RSF (for remodeling and spacing factor) is composed of two subunits: the ATPase hSNF2H p325 (Rsf-1), a protein encoded by novel gene. We previously showed that mediates nucleosome deposition generates regularly spaced arrays. Here we report characterization largest subunit RSF, Rsf-1. found Rsf-1 highly acidic containing plant homology domain. present study includes cloning Rsf-1, preparation recombinant dissection role each in chromatin assembly reaction....
Nopp140 is thought to shuttle between nucleolus and cytoplasm. However, the predominant nucleolar localization of homologues from different species suggests that also involved in events occurring within nucleolus. In this study, we demonstrated largest subunit RNA polymerase I, RPA194, was coimmunoprecipitated with human (hNopp140). Such an interaction mediated through amino acids 204 382 hNopp140. By double immunofluorescence, hNopp140 colocalized I at rDNA (rRNA genes) transcription active...
Abstract In most solid tumors, cellular energy metabolism is primarily dominated by aerobic glycolysis, which fulfills the high demand for biomacromolecules at expense of reduced ATP production efficiency. Elucidation mechanisms rapidly proliferating malignant cells acquire sufficient in this state inefficient from glycolysis could enable development targeted therapeutic strategies. study, we observed a significant association between elevated expression levels long non-coding RNA (lncRNA)...
Abstract Background Diabetic cystopathy (DCP) is linked to bladder nerve conduction disorders, with diabetes-induced neuropathy impairing signal transmission and causing dysfunction. Myosin 5a, vital for neuronal transport, has been neurological though its role in DCP remains unclear. The objective of this study was investigate whether 5a plays a potential regulatory Cystopathy. Methods Bladder strips from diabetic rats were use assess heightened responsiveness external stimuli. Urodynamic...
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<div>Abstract<p>In most solid tumors, cellular energy metabolism is primarily dominated by aerobic glycolysis, which fulfills the high demand for biomacromolecules at expense of reduced ATP production efficiency. Elucidation mechanisms rapidly proliferating malignant cells acquire sufficient in this state inefficient from glycolysis could enable development metabolism-targeted therapeutic strategies. In study, we observed a significant association between elevated expression...
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Coronary artery disease (CAD) is a complex condition influenced by genetic factors, lifestyle, and other risk factors that contribute to increased mortality. This study aimed at evaluating the diagnostic potential of genes associated with cuproptosis, ferroptosis, pyroptosis (CFP) using network modularization machine learning methods. CAD‐related datasets GSE42148, GSE20680, GSE20681 were sourced from GEO database, related CFP gathered MsigDB FerrDb literature. To identify linked these...
Abstract The precise regulation of STING homeostasis is essential for its antiviral function. Post-translational modification, especially ubiquitination, important the homeostasis. Previous studies have focused on how degraded, but little known about maintenance. Here, we show that UFM1 specific ligase UFL1 promotes innate immune response by maintaining expression independent UFMylation. Mechanistically, inhibits TRIM29 to interact with STING, thereby reducing ubiquitination at...
Pancreatic progenitor cell differentiation and proliferation factor (PPDPF) has been reported to play a role in tumorigenesis. However, its function hepatocellular carcinoma (HCC) remains poorly understood. In this study, we report that PPDPF is significantly downregulated HCC the decreased expression indicates poor prognosis. dimethylnitrosamine (DEN)-induced mouse model, hepatocyte-specific depletion of Ppdpf promotes hepatocarcinogenesis, reintroduction into liver-specific knockout (LKO)...
Lipid modification on the cysteine residues of proteins, known as S-palmitoylation or S-acylation, regulates subcellular localization and function proteins. S-acylation is catalysed by a group protein acyltransferases (PATs) with conserved Asp-His-His-Cys (DHHC) motif. The molecular has been studied in details yeast mammalian cells, but its role plant cells remains unclear. Here it reported that expression two homologous acyltransferases— PAT13 PAT14 —was moderately increased older leaves...
While buffer cocktails remain the most commonly used method for photostabilization and photoswitching of fluorescent markers, intramolecular triplet-state quenchers emerge as an alternative strategy to impart fluorophores with 'self-healing' or even functional properties such photoswitching. In this contribution, we evaluated combinations both approaches show that inter- quenching processes compete each other. We find although rate is additive, photostability limited by faster pathway. Often...
Abstract Background Gastrointestinal tract (GIT) nematodes prefer to live in the intestines of wild animals, causing damage and even death, posing a zoonotic risk. The polyparasitism GIT results complex dynamics nematode communities that occur naturally animals. However, community captive animals is poorly understood. Methods We combined microscopic examination amplicon sequencing for diversity. Results characterized assemblages one order, family, four genera, ten species, 512 fecal samples...
GATA transcription factor is crucial for plant growth and development, physiological metabolism, environmental response, which has been reported in many plants. Although the identification of maize genes previously, number was incomplete, expression patterns were not analyzed. Therefore, this study, gene family (Zea mays L.) systematically Forty-one identified divided into four groups. The structure each subgroup basically consistent with that motif. distributed on 10 chromosomes, including...
Seawater intrusion has occurred in the coastal area of Yellow Sea and Bohai as early 1970s, situation is worsening, with rapid socioeconomic development recent years. Substantial amounts groundwater have been exploited to support activities, especially agricultural causing a reduction level, hence seawater. This issue seriously restricts sustainable these areas. To this end, paper applied improved Tapio decoupling theory analyze degree decoupling, spatial difference between economic growth...