A5008394519- Epigenetics and DNA Methylation
- Hearing, Cochlea, Tinnitus, Genetics
- Pomegranate: compositions and health benefits
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Bioactive Compounds in Plants
- Histone Deacetylase Inhibitors Research
- Congenital heart defects research
- Cardiovascular Disease and Adiposity
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Heat shock proteins research
- Genetics and Neurodevelopmental Disorders
- Neurological Disease Mechanisms and Treatments
- Mesenchymal stem cell research
- Curcumin's Biomedical Applications
- Neuroscience and Neuropharmacology Research
- Social and Behavioral Studies
- Connexins and lens biology
- Neurotransmitter Receptor Influence on Behavior
- Tissue Engineering and Regenerative Medicine
- Nicotinic Acetylcholine Receptors Study
- Tryptophan and brain disorders
Sun Yat-sen University
2023-2025
Changsha Medical University
2023-2024
Second Affiliated Hospital of Guangzhou Medical University
2017-2022
Guangzhou Medical University
2017-2022
National Natural Science Foundation of China
2020
University of Minnesota Medical Center
2001
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and impaired neurogenesis. Urolithin A (UA), gut-microbial metabolite ellagic acid, has been reported to exert anti-inflammatory effects in the brain. However, it unknown whether UA exerts its properties anti-inflammation neuronal protection APPswe/PS1ΔE9 (APP/PS1) mouse model AD. Morris water maze was used detect cognitive function....
Although valproic acid (VPA), has been shown to induce neuronal differentiation of neural stem cells (NSCs), the underlying mechanisms remain poorly understood. Here we investigated if and how mammalian target rapamycin (mTOR) signaling is involved in VPA-induced NSCs. Our data demonstrated that mTOR activation not only promoted but also was necessary for NSCs induced by VPA. We further found inhibition blocked demethylation neuron-specific gene neurogenin 1 (Ngn1) regulatory element cells....
Increased neurogenesis elicits antidepressive-like effects. The antidiabetic drug metformin (Met) reportedly promotes hippocampal neurogenesis, which ameliorates spatial memory deficits and depression-like behaviors. However, the precise molecular mechanisms underpinning Met-induced neuronal differentiation of neural stem cells (NSCs) remain unclear. We showed that Met enhanced NSCs via Gadd45g but not Gadd45a Gadd45b. further found increased demethylation neurogenic 1 promoter by regulating...
It is well-established that overweight/obesity a major risk factor for left ventricular hypertrophy (LVH) in childhood. However, it still unclear if reversing from to normal weight associated with decreased LVH children. This study aimed examine the association between status change during four years and among Chinese children based on prospective cohort study.
Background Alzheimer’s disease (AD) is characterized by neuroinflammation, which frequently accompanied immune system dysfunction. Although the mechanism of neurodegenerative lesions unclear, various clinical trials have highlighted that early intervention in AD crucial to success treatment. In order explore potential immunotherapy period AD, present study evaluated whether application glatiramer acetate (GA), an immunomodulatory agent approved for remitting–relapsing multiple sclerosis...
Abstract Gap junction connexin 26 ( Cx26 ) is up‐regulated in mammary epithelial cells during pregnancy and lactation. To understand the transcriptional regulation of , we identified a protected DNase I footprint region (−140 to −113) rat promoter. This r Promoter Footprinting Region, or CPFR, contains an Sp binding site (CC GCCC overlapping with AP‐2 GCGGC), evolutionarily conserved. Nuclear...
<title>Abstract</title> Parkinson’s disease (PD) is the world’s second most prevalent neurodegenerative disease. Currently, aside from levodopa, there are no other effective drugs clinically available to slow its progression. Otx2 plays a critical role in differentiation of midbrain dopaminergic neurons (mDANs) during development. However, adulthood, primarily expressed ventral tegmental area (VTA)-ventral part, and mDANs dorsal part VTA substantia nigra pars compacta (SNc) show expression....
Purpose This study aimed to investigate the repair of bone defects in rabbits with tissue-engineered bones using cocultured endothelial progenitor cells (EPCs) and marrow mesenchymal stem (BMSCs) as seeding cells. Methods Endothelial BMSCs were isolated purified from peripheral blood marrow, respectively, New Zealand rabbits. The third passage was cultured alone or EPCs. Cells characterized specific markers then seeded on partially deproteinized biologic pigs a scaffold. engineered used...
Background Schizophrenia is a complex mental disorder with chronic course. The atypical antipsychotics represented by lurasidone are commonly used in schizophrenia, and its mechanism of action determines the superiority efficacy safety. However so far, there still some adverse reactions, which more significant lethargy, nausea, sedentary inability. In view these situations, we will combine nutrition intervention use to eliminate reactions provide help for formulation treatment plans....
The massive cell death of dopaminergic neurons (DANs) in substantia nigra pars compacta (SNC) is associated with motor diseases, such as Parkinson's disease. Moreover, a subtype DANs SNC, ALDH1A1