A5085360666- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Physical Activity and Health
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Health disparities and outcomes
- Body Composition Measurement Techniques
- Smoking Behavior and Cessation
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Air Quality and Health Impacts
- Heart Rate Variability and Autonomic Control
- Children's Physical and Motor Development
- Global Public Health Policies and Epidemiology
- Health, Environment, Cognitive Aging
- Cerebrovascular and Carotid Artery Diseases
- Obesity and Health Practices
- Cardiovascular and exercise physiology
University of Turku
2016-2025
Turku University Hospital
2016-2025
Baker Heart and Diabetes Institute
2022-2025
University of South Australia
2020-2025
The University of Melbourne
2012-2025
University of Tasmania
2015-2024
Menzies Institute for Medical Research
2016-2022
Menzies School of Health Research
2011-2022
Chinese Center For Disease Control and Prevention
2022
Fimlab (Finland)
2022
Childhood cardiovascular risk factors predict subclinical adult disease, but links to clinical events are unclear. In a prospective cohort study involving participants in the International Cardiovascular Cohort (i3C) Consortium, we evaluated whether childhood (at ages of 3 19 years) were associated with adulthood after mean follow-up 35 years. Body-mass index, systolic blood pressure, total cholesterol level, triglyceride and youth smoking analyzed use i3C-derived age- sex-specific z scores...
Background— Atherosclerosis has its roots in childhood. Therefore, defining the age when childhood risk exposure begins to relate adult atherosclerosis may have implications for pediatric cardiovascular disease prevention and provide insights about early determinants of development. The aim this study was investigate influence on associations between factors carotid artery intima-media thickness, a marker subclinical atherosclerosis. Methods Results— We used data 4380 members 4 prospective...
Abstract Objective To determine the association between recommended physical activity according to 2018 guidelines for Americans and all cause specific mortality using a nationally representative sample of US adults. Design Population based cohort study. Setting National Health Interview Survey (1997-2014) with linkage Death Index records 31 December 2015. Participants 479 856 adults aged 18 years or older. Exposures Participant self-reports amount leisure time spent in aerobic muscle...
Background— The clinical utility of identifying pediatric metabolic syndrome (MetS) is controversial. This study sought to determine the status MetS as a risk factor for adult subclinical atherosclerosis (carotid intima-media thickness [cIMT]) and type 2 diabetes mellitus (T2DM) compare contrast this prediction with its individual components. Methods Results— Using data from population-based, prospective, observational Bogalusa Heart Cardiovascular Risk in Young Finns studies, we examined 4...
Background— The American Heart Association (AHA) defined a new concept, cardiovascular health, and determined metrics needed to monitor it over time as part of its 2020 Impact Goal definition. Ideal health is by the presence both ideal behaviors factors. applicability this concept cohort children relationship with cardiometabolic outcomes in adulthood has not been reported. Methods Results— sample comprised 856 participants aged 12 18 years (mean age 15.0 years) from Cardiovascular Risk...
The relationship between life-course body mass index (BMI) trajectories and adult risk for cardiovascular disease (CVD) is poorly described. In a longitudinal cohort, we describe BMI from early childhood to adulthood investigate their association with CVD factors [Type 2 diabetes mellitus (T2DM), high-risk lipid levels, hypertension, high carotid intima-media thickness (cIMT)] in (34-49 years).Six discrete long-term were identified using latent class growth mixture modelling among 2631...
The American Heart Association recently updated its construct of what constitutes cardiovascular health (CVH), called Life's Essential 8. We examined the association total and individual CVH metrics according to 8 with all-cause disease (CVD)-specific mortality later in life.Data were from National Health Nutrition Examination Survey (NHANES) 2005-2018 at baseline linked 2019 Death Index records. Total metric scores including diet, physical activity, nicotine exposure, sleep health, body...
BackgroundThe World Health Assembly set a global target of increasing exclusive breastfeeding for infants under 6 months to at least 50% by year 2025. However, little is known about the current status practice, as well trends in practices during recent years. We examined prevalence Organization (WHO) feeding 57 low- and middle-income countries (LMICs) time since 2000 44 selected countries.MethodsWe included eligible LMICs that had completed data on complementary 2010–2018 from Demographic...
Understanding the temporal trends in burden of overall and type-specific cardiovascular diseases (CVDs) youths young adults its attributable risk factors is important for effective targeted prevention strategies measures. We aimed to provide a standardized comprehensive estimation prevalence, incidence, disability-adjusted life years (DALY), mortality rate CVDs associated aged 15-39 at global, regional, national levels.We applied Global Burden Disease, Injuries, Risk Factors Study (GBD) 2019...
Importance Elevated non–high-density lipoprotein cholesterol (non–HDL-C; a recommended measure of lipid-related cardiovascular risk) is common in children and increases risk adult disease (CVD). Whether resolution elevated childhood non–HDL-C levels by adulthood associated with reduced clinical CVD events unknown. Objective To examine the associations status between incident events. Design, Setting, Participants Individual participant data from 6 prospective cohorts (mean age at baseline,...
Importance Recent evidence suggests that childhood levels of serum lipids, blood pressure, body mass index (BMI), and smoking contribute to adult risk cardiovascular disease (CVD). Evidence is lacking on whether this independent levels. Objective To quantify direct indirect effects factors CVD via adulthood using mediation analysis, their relative importance during different life-course stages a approach. Design, Setting, Participants This prospective cohort study followed participants from...
A high childhood body mass index (BMI) is associated with a risk of obesity in adulthood. Several studies have shown adverse long-term outcomes childhood, including type 2 diabetes mellitus and cardiovascular disease. It unclear whether increased as an adult predetermined consequence or these effects can be reversed obese children who become nonobese adults. This observational study was designed to compare the disease among adults without history overweight during childhood. Data were pooled...
There is paucity of knowledge concerning the specific age in youth when associations metabolic syndrome (MetS) begin to be operative. Thus, we investigated relation childhood MetS with adult MetS, type 2 diabetes mellitus and high carotid intima-media thickness.Five thousand eight-hundred three participants were analyzed 4 cohort studies (Cardiovascular Risk Young Finns, Bogalusa Heart Study, Princeton Lipid Research Insulin Study). International cutoffs previously used 75th percentile for...
AimsHigh-throughput metabolite quantification holds promise for cardiovascular risk assessment. Here, we evaluated whether by nuclear magnetic resonance (NMR) improves prediction of subclinical atherosclerosis in comparison to conventional lipid testing.
OBJECTIVE To examine how fitness in both childhood and adulthood is associated with adult obesity insulin resistance. RESEARCH DESIGN AND METHODS A prospective cohort study set Australia 2004–2006 followed up a of 647 adults who had participated the Australian Schools Health Fitness Survey 1985 undergone anthropometry cardiorespiratory assessment during survey. Outcome measures were resistance obesity, defined as homeostasis model index above 75th sex-specific percentile BMI ≥30 kg/m2,...
Background— New age- and sex-specific lipoprotein cut points developed from National Health Nutrition Examination Survey (NHANES) data are considered to be a more accurate classification of high-risk level in adolescents compared with existing established by the Cholesterol Education Program (NCEP). The aim this study was determine which NHANES or NCEP adolescent classifications most effective for predicting abnormal levels adulthood. Methods Results— Adolescent adult measures total...
Hypertension is a major modifiable cardiovascular risk factor. The present longitudinal study aimed to examine the best combination of childhood physical and environmental factors predict adult hypertension furthermore whether newly identified genetic variants for blood pressure increase prediction hypertension.The cohort included 2625 individuals from Cardiovascular Risk in Young Finns Study who were followed up 21 27 years since baseline (1980; age, 3-18 years). In addition dietary...