A5019865568- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Coronary Interventions and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Cardiac Valve Diseases and Treatments
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Cardiovascular and exercise physiology
- Cerebrovascular and Carotid Artery Diseases
- Nitric Oxide and Endothelin Effects
- Birth, Development, and Health
- Pharmacogenetics and Drug Metabolism
- Hormonal and reproductive studies
- Inflammatory mediators and NSAID effects
- Cardiovascular Effects of Exercise
- Respiratory and Cough-Related Research
- Pulmonary Hypertension Research and Treatments
- Respiratory viral infections research
- Lysosomal Storage Disorders Research
Turku University Hospital
2008-2022
University of Turku
2003-2022
Turku PET Centre
1995-2011
National Research Council
2010
Istituto di Fisiologia Clinica
2010
Kajaani University of Applied Sciences
2008
Tampere University
2002-2006
Tampere University Hospital
2002-2006
Czech Academy of Sciences, Institute of Physiology
2002
Social Insurance Institution
2002
Background — Autopsy studies in children have shown that atherosclerotic lesions begin to develop first the intima of aorta. Recent developments ultrasound techniques made it possible visualize intima-medial thickness abdominal aorta directly (aIMT). Therefore, we examined feasibility measuring aIMT and studied its value distinguishing high-risk from healthy controls compared with a more established marker subclinical atherosclerosis, common carotid artery (cIMT). Methods Results IMTs were...
Background— Computed tomography (CT) is increasingly used to detect coronary artery disease, but the evaluation of stenoses often uncertain. Perfusion imaging has an established role in detecting ischemia and guiding therapy. Hybrid positron emission (PET)/CT allows combination angiography perfusion short, quantitative, low-radiation-dose protocols. Methods Results— We enrolled 107 patients with intermediate (30% 70%) pretest likelihood disease. All underwent PET/CT (quantitative PET 15...
Objective— Elevated serum concentration of C-reactive protein (CRP) predicts cardiovascular events in adults. Because atherosclerosis begins childhood, we undertook a study to determine whether changes brachial artery endothelial function and the thickness carotid intima-media complex, 2 markers early atherosclerosis, are related CRP levels healthy children. Methods Results— Brachial flow-mediated dilatation (FMD) (IMT) were measured with ultrasound 79 children (aged 10.5±1.1 years)....
Left ventricular (LV) volumes and mass were evaluated in 10 healthy volunteers with breath-hold cine magnetic resonance (MR) imaging. The results compared those obtained conventional MR studies showed no ghosting artifact, cardiac edges clearly identified because of the reduced blurring. Measurements LV end-diastolic volume (LVEDV), end-systolic (LVESV), imaging close correlation (r = .98, .97, .99, respectively). interobserver variabilities for LVEDV, LVESV, determined (4.0%, 8.0%, 3.7%,...
Obesity is associated with endothelial dysfunction that may contribute to the development of atherosclerosis. We studied whether weight reduction improves function in overweight individuals.Flow-mediated endothelium-dependent vasodilation brachial artery was measured 67 adults (age: 46+/-7 years, body mass index: 35.2+/-5.4 kg/m2) before and after a 6-week program induced by very-low-calorie diet (daily energy: 580 kcal/2.3 MJ). Caloric restriction reduced from 101+/-18 90+/-17 kg....
The standard interpretation of perfusion imaging is based on the assessment relative distribution. limitations that approach have been recognized in patients with multivessel disease and endothelial dysfunction. To date, however, no large clinical studies investigated value measuring quantitative blood flow compared uptake.One hundred four moderate (30%-70%) pretest likelihood coronary artery (CAD) underwent PET during adenosine stress using (15)O-water dynamic imaging. Absolute myocardial...
Detection of early vascular changes indicated by lowered coronary flow reserve (CFR) would allow treatment and prevention atherosclerosis. The purpose this study was to test whether it is possible reproducibly measure CFR with transthoracic Doppler echocardiography (TTE) in healthy volunteers. We measured using dipyridamole infusion ten male volunteers two methods: TTE positron emission tomography (PET) oxygen‐15‐labelled water (group A). However, assessed twice eight B) the reproducibility...
Background The regulation of glucose uptake in the dysfunctional but viable myocardium has not been studied previously humans. Methods and Results Seven patients with an occluded major coronary artery no previous infarction were twice 2-[ 18 F]fluoro-2-deoxy- d -glucose positron emission tomography, once fasting state during hyperinsulinemic euglycemic clamping. Myocardial blood flow was measured [ 15 O]H 2 O. myocardial region beyond that showed stable wall-motion abnormality represented...
Jartti T, Kuusipalo H, Vuorinen Söderlund-Venermo M, Allander Waris Hartiala J, Ruuskanen O. Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children.Pediatr Allergy Immunol 2010: 21: 1008–1014.© 2010 John Wiley & Sons A/S Background: Data on the link between atopy and viral wheeze are limited. Aim: To evaluate association IgE infection children. Methods: This an observational study hospitalized children (n = 247; median age 1.6 ;...
Abstract —We used borderline hypertension as a model for prehypertension to examine the early influences of elevated blood pressure on subclinical atherosclerosis, lipoprotein oxidation, and cardiac adaptation. Healthy men (age 37±4 years) were classified prospectively into 2 groups basis having either (systolic 130 140 mm Hg or diastolic 85 89 Hg, n=16) normal (<130/85 n=22) values during previous years. The matched age, body size, serum cholesterol levels. High-resolution ultrasound was...
Abstract —Measures of arterial elasticity have been proposed as surrogate markers for asymptomatic atherosclerosis. We investigated the relations serum lipoproteins, oxidized low-density lipoprotein (ox-LDL), and familial hypercholesterolemia (FH) to among young men. As a marker we measured compliance in thoracic aorta by using magnetic resonance imaging common carotid artery ultrasound. LDL diene conjugation was used ox-LDL. In study I, 25 healthy men (aged 29 39) were classified into 2...
To characterize brachial artery flow-mediated dilatation (FMD) in children, we monitored arterial diameter changes with ultrasound between 40 and 180 s after a 4.5-min forearm cuff occlusion-induced hyperemia 105 healthy children (mean age, 11 yr; range, 9–16 yr). The peak FMD was 7.7 ± 4.0% occurred 79 33 release. at 60 (5.3 4.0%) significantly lower than the ( P < 0.0001). Twenty-three percent of n = 24) reached first 110 postocclusion. Compared others, these late responders weighed...
The role of systemic corticosteroids in the treatment early childhood wheezing children is not clear.We sought to determine whether prednisolone effective rhinovirus-induced wheezing.We conducted a controlled trial comparing oral (2 mg/kg per day three divided doses for 3 days) with placebo 78 hospitalized (mean age, 1.1 year; standard deviation, 0.7) experiencing their first or second episode induced by rhinovirus respiratory syncytial virus. Mixed viral infections were excluded. Our...
1. The effects of exposure rats to cigarette smoke have been studied on the metabolism vasoactive hormones in isolated lungs from these animals. 2. Rats were exposed for 1 h per day or 10 days. 3. Angiotensin I conversion was increased after day's but days' returned normal. 4. Inactivation prostaglandin E2 decreased exposure. After there a further decrease which could not be attributed alone. 5. inactivation 5-hydroxytryptamine and bradykinin remained unchanged both short longer exposures...
Background: Perioperative myocardial ischaemia is an important risk factor for cardiac morbidity and mortality after noncardiac surgery. The impact of analgesic management on the incidence severity ischemia was studied in 77 elderly patients undergoing surgical treatment traumatic hip fracture. Methods: After hospital admission written consent, were randomised to conventional regimen (intramuscular oxycodone, OPI group) or continuous epidural infusion bupivacaine/fentanyl (EPI group)....
Common naturally occurring polymorphisms have been identified in the coding regions of α1A-, α2B-, β1- and β2-adrenoceptor (AR) genes [α1A-AR R492C, α2B-AR insertion/deletion (I/D), β1-AR R389G, β2-AR G16R Q27E] are associated with modified vivo vitro functionality. We tested their possible effects on haemodynamic responses to intravenous adrenaline (20, 40, 80 160ng/kg body weight per min; 5min for each infusion rate) before after β-blockade (propranolol) 16 young healthy men. monitored...
Finnish men have higher coronary heart disease (CHD) mortality than Swedish do. To assess the impact of migration to a country with lower CHD on subclinical atherosclerosis, we measured early functional and structural atherosclerotic vascular changes in twins discordant for from Finland Sweden. Conventional risk factors, flow-mediated dilatation (FMD) brachial artery, carotid intima-media thickness, artery compliance were 74 male twin pairs (20 monozygous, 54 dizygous), aged 42 69 years,...
Abstract Myocardial perfusion reserve (MPR, defined as the ratio of maximum myocardial blood flow (MBF) to baseline) is an indicator coronary artery disease and microvascular abnormalities. First‐pass contrast‐enhanced magnetic resonance imaging (CE‐MRI) using gadolinium (Gd)‐DTPA a contrast agent (CA) has been used assess MPR. Tracer kinetic models based on compartmental analysis CA uptake have developed provide quantitative measures MBF by MRI. To study accuracy Gd‐DTPA first‐pass MRI...