A5085741485- Cardiac Imaging and Diagnostics
- Sarcoidosis and Beryllium Toxicity Research
- Advanced MRI Techniques and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Coronary Interventions and Diagnostics
- Medical Imaging and Pathology Studies
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Advanced X-ray and CT Imaging
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Vasculitis and related conditions
- COVID-19 and healthcare impacts
- Viral Infections and Immunology Research
- Parathyroid Disorders and Treatments
- Healthcare cost, quality, practices
- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- Clinical practice guidelines implementation
- Cardiomyopathy and Myosin Studies
Helsinki University Hospital
2017-2025
University of Helsinki
2020-2025
Turku PET Centre
2012-2024
University of Turku
2014-2024
Turku University Hospital
2014-2024
Fondazione Toscana Gabriele Monasterio
2024
University of Siena
2024
Uppsala University
2015
Amsterdam UMC Location Vrije Universiteit Amsterdam
2014
Cardiac sarcoidosis (CS) results from epithelioid cell granulomas infiltrating the myocardium and predisposing to conduction disturbances, ventricular tachyarrhythmias, heart failure. Manifest CS, however, constitutes only top of an iceberg as advanced imaging uncovers cardiac involvement 4 5 times more commonly than what is clinically detectable. Definite diagnosis CS requires myocardial biopsy histopathology, but a sufficient diagnostic likelihood can be achieved by combining extracardiac...
Cardiac sarcoidosis (CS) predisposes to sudden cardiac death (SCD). Guidelines for implantable cardioverter defibrillators (ICDs) in CS have been issued by the Heart Rhythm Society 2014 and American College of Cardiology/American Association/Heart consortium 2017. How well they discriminate high from low risk remains unknown.
Background— Quantitative myocardial perfusion imaging is increasingly used for the diagnosis of coronary artery disease. allows to noninvasively calculate fractional flow reserve (FFR). This so-called relative (RFR) defined as ratio hyperemic blood (MBF) in a stenotic area MBF normal perfused area. The aim this study was assess value RFR detection significant Methods and Results— From clinical population patients with suspected disease who underwent oxygen-15–labeled water cardiac positron...
In cardiac sarcoidosis (CS), the risk and predictors of new-onset atrial fibrillation (AF) are poorly known. The authors evaluated incidence characteristics AF in newly diagnosed CS. studied 118 patients (78 women, mean age 50 years) with AF-naive CS having undergone 18F-fluorodexoyglucose positron emission tomography (18F-FDG PET) at time diagnosis. Details patient medical or device therapy were collected from hospital charts. PET scans re-analyzed for presence ventricular inflammation,...
This study validates the accuracy of 99mTc-hydroxymethylene diphosphonate ([99mTc]Tc-HMDP) single-photon emission tomography / computed (SPECT/CT) in diagnosis transthyretin amyloidosis (ATTR) cardiomyopathy using myocardium-to-blood ratio (MBR). The final population was 80 patients who underwent [99mTc]Tc-HMDP SPECT/CT for suspected ATTR at Helsinki University Hospital or Jorvi Central Finland. Patients were diagnosed according to currently accepted European Society Cardiology criteria as...
Transthyretin amyloidosis (ATTR) is a progressive disease which can be diagnosed non-invasively using bone avid [99mTc]-labeled radiotracers. Thus, ATTR also an occasional incidental finding on scintigraphy. In this study, we trained convolutional neural networks (CNN) to automatically detect and classify from scintigraphy images. The study population consisted of 1334 patients who underwent hydroxymethylene diphosphonate (HMDP) were visually graded Perugini grades (grades 0-3). A total 47...
Left ventricular assist devices (LVADs) are gaining increasing importance as therapeutic strategy in advanced heart failure (HF), not only bridge to recovery or transplant but also destination therapy. Even though long-term LVADs considered a precious resource expand the treatment options and improve clinical outcome of these patients, limited by peri-operative post-operative complications, such device-related infections, haemocompatibility-related events, device mis-positioning, right...
Coronary microvascular dysfunction (CMD) can cause angina in the absence of obstructive coronary artery disease (CAD). We studied frequency and angiographic characteristics CMD symptomatic patients with suspected stable CAD identified as diffusely abnormal vasodilator capacity by positron emission tomography (PET) perfusion imaging.We recruited prospectively 189 intermediate pre-test probability who underwent computed angiography quantitative 15O-water PET imaging followed invasive...
Cardiovascular diseases (CVD) represent an important cause of mortality and morbidity in women. It is now recognized that there are sex differences regarding the prevalence clinical significance traditional cardiovascular (CV) risk factors as well pathology underlying a range CVDs. Unfortunately, women have been under-represented most CVD imaging studies trials diagnosis, prognosis, therapeutics. There therefore clear need for further investigation how affects along their life span....
Transthyretin amyloidosis (ATTR) is an occasional incidental finding on bone scintigraphy. We studied its prognostic impact in elderly patients.
Background Long-term symptoms are frequent after coronavirus disease 2019 (COVID-19). We studied the prevalence of post-acute myocardial scar on cardiac magnetic resonance imaging (CMR) in patients hospitalized due to COVID-19 and its association with long-term symptoms. Materials methods In this prospective observational single-center study, 95 formerly underwent CMR at median 9 months acute COVID-19. addition, 43 control subjects were imaged. Myocardial characteristic infarction or...
This study evaluated the prevalence and prognostic significance of cardiac transthyretin amyloidosis (ATTR) diagnosed using 99mTc- hydroxymethylene-diphosphonate (99mTc-HMDP) scintigraphy in an elderly heart failure population.This retrospective included 335 patients aged >70 years with who underwent 99mTc-HMDP due to non-cardiac reasons three imaging centres Finland (Kymenlaakso Central Hospital, Jorvi Meilahti University Hospital). A Perugini grade >2 heart-to-contralateral ratio (H/CL)...
Coronary computed tomography angiography is increasingly used as the first-line test for suspected coronary artery disease. Its overuse in a low pretest probability (PTP) population may lead to diagnostic yield without change patient management. We evaluated clinical consequences of updated 2019 European Society Cardiology (ESC) chronic syndromes guidelines' PTP estimation and whether imaging could be safely deferred patients with PTP.
We studied whether a reduced coronary flow reserve (CFR) in healthy young men independently predicts the presence of artery disease as assessed by calcification after 11 years follow-up. Coronary microvascular dysfunction early stages can be detected CFR positron emission tomography (PET). Seventy-seven healthy, lean, normotensive, non-smoking and non-diabetic underwent 15-Oxygen (15O) water myocardial perfusion PET at rest during vasodilator stress age 35 ± 4 baseline. The subjects were...