A5026732691- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Cardiovascular Issues in Pregnancy
- Medical Imaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Cardiac and Coronary Surgery Techniques
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Chronic Lymphocytic Leukemia Research
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mechanical Circulatory Support Devices
- Central Venous Catheters and Hemodialysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
Amsterdam UMC Location VUmc
2014-2024
Amsterdam University Medical Centers
2018-2024
Leiden University Medical Center
2024
Medisch Centrum Leeuwarden
2024
University Medical Center Groningen
2024
Erasmus University Rotterdam
2024
Amsterdam Neuroscience
2022-2024
Vrije Universiteit Amsterdam
2007-2023
Hospital do Servidor Público Estadual
2022-2023
Instituto de Assistência Médica ao Servidor Público Estadual
2022-2023
This study investigated the relationship between right ventricular (RV) structure and function survival in idiopathic pulmonary arterial hypertension (IPAH).In 64 patients, cardiac magnetic resonance, heart catheterization, six-minute walk test (6MWT) were performed at baseline after 1-year follow-up. RV analysed as predictors of mortality. During a mean follow-up 32 months, 19 patients died. A low stroke volume (SV), dilatation, impaired left (LV) filling independently predicted In...
Background: Coronary microvascular dysfunction (CMD) is an important contributor to angina syndromes.Recently, two distinct endotypes were identified using combined assessment of coronary flow reserve (CFR) and minimal resistance (MR), termed structural functional CMD. Aims:We aimed assess the relevance CFR MR in patients with no obstructive arteries.Methods: Patients chronic syndromes (CCS) non-obstructive artery disease (fractional [FFR] ≥0.80) selected (N=1,102).Functional CMD was defined...
The microvascular resistance reserve (MRR) was introduced as a means to characterize the vasodilator capacity of coronary microcirculation while accounting for influence concomitant epicardial disease and impact administration potent vasodilators on aortic pressure. This study aimed evaluate diagnostic prognostic performance MRR.A total 1481 patients with stable symptoms clinical indication angiography were included from global ILIAS Registry. MRR derived function flow (CFR) divided by...
Right ventricular (RV) afterload is commonly defined as pulmonary vascular resistance, but this does not reflect the to pulsatile flow. The purpose of study was quantify RV more completely in patients with and without hypertension (PH) using a three-element windkessel model. model consists peripheral resistance (R), arterial compliance (C), characteristic impedance (Z). Using artery pressure from right-heart catheterization flow MRI velocity quantification, we estimated parameters chronic...
The aim of this study was to investigate the contribution direct right-to-left ventricular interaction left filling and stroke volume in 46 patients with pulmonary arterial hypertension (PAH) 18 control subjects. Stroke volume, right volumes, rate, interventricular septum curvature were measured by magnetic resonance imaging atrial transesophageal echocardiography. end-diastolic peak rate decreased PAH compared subjects: 28 +/- 13 vs. 41 10 ml/m(2) (P < 0.001), 14 61 216 90 541 248 ml/s...
Pulmonary arterial compliance (C) is increasingly being recognized as an important contributor to right ventricular afterload, but for monitoring of treatment pulmonary hypertension (PH) most often still only vascular resistance (R) used. We aimed at testing the hypothesis that R and C are coupled during PH substantial changes in both would result more haemodynamic improvement than alone. Data were analysed two right-heart catheterizations 52 patients with 10 chronic-thromboembolic PH. The...
This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs coronary artery (RCA) flow and RV perfusion. In 25 subjects, five patients with idiopathic arterial hypertension, nine chronic thromboembolic 11 healthy controls, of the RCA left anterior descending (LAD) was measured MR quantification. PH, peak systolic mean were lower, 1.02 ± 0.62 mL/s 0.42 0.30 mL/s, than diastolic flow, 2.99 1.97 ( P < 0.001) 1.73 0.97 0.001); a pattern...
Background In the absence of obstructive coronary stenoses, abnormality noninvasive stress tests (NIT) in patients with chronic syndromes may indicate myocardial ischemia nonobstructive arteries (INOCA). The differential prognosis INOCA according to presence microvascular dysfunction (CMD) and incremental prognostic value CMD intracoronary physiologic assessment on top NIT information remains unknown. Methods Results From international multicenter registry (ILIAS [Inclusive Invasive...
Early P2Y
Abstract Purpose To assess the accuracy of several noninvasive MRI‐based estimators pulmonary artery pressure by comparing them with invasive measurement. Materials and Methods We compared five MRI methods measurement catheterization, in one group hypertension (PH) patients. Doppler echocardiography was included as a reference method. Main inclusion criterion mean above 25 mmHg at catheterization. velocity quantification used to obtain flow acceleration ejection times, pulse wave velocity....
Since systemic sclerosis (SSc) also involves the heart, aim of present study was to evaluate possible differences in right ventricular (RV) pump function between SSc-associated pulmonary arterial hypertension (PAH; SScPAH) and idiopathic PAH (IPAH). In 13 limited cutaneous SScPAH 17 IPAH patients, RV described using graph, which relates mean pressure ((RV)) stroke volume index (SVI). Differences result shift or rotation graph. SVI were measured standard catheterisation. The hypothetical...
This study sought to examine the clinical performance of and theoretical basis for instantaneous wave-free ratio (iFR) approximation fractional flow reserve (FFR).Recent work has proposed iFR as a vasodilation-free alternative FFR making mechanical revascularization decisions. Its fundamental is assumption that diastolic resting myocardial resistance equals mean hyperemic resistance.Pressure-only combined pressure-flow data from several centers were studied both empirically by using...
Background— Quantitative myocardial perfusion imaging is increasingly used for the diagnosis of coronary artery disease. allows to noninvasively calculate fractional flow reserve (FFR). This so-called relative (RFR) defined as ratio hyperemic blood (MBF) in a stenotic area MBF normal perfused area. The aim this study was assess value RFR detection significant Methods and Results— From clinical population patients with suspected disease who underwent oxygen-15–labeled water cardiac positron...
Abstract Aims Continuous thermodilution is a novel technique to quantify absolute coronary flow and microvascular resistance (MVR). Notably, intracoronary infusion of saline elicits maximal hyperaemia, obviating the need for adenosine. The primary aim this study was validate continuous in humans by comparing invasive measurements [15O]H2O positron emission tomography (PET). As secondary goal, MVR were compared between obtained with without Methods results Twenty-five patients underwent...
Background During primary percutaneous coronary intervention (PCI), a concurrent chronic total occlusion (CTO) is found in 10% of patients with ST-elevation myocardial infarction (STEMI). Long-term benefits CTO-PCI have been suggested; however, randomised data are lacking. Our aim was to determine mid-term and long-term clinical outcome versus CTO-No PCI STEMI CTO. Methods The Evaluating Xience left ventricular function on occlusiOns afteR (EXPLORE) multicentre trial that included 302 after...
A total of 40% to 50% patients with ST-segment-elevation myocardial infarction develop microvascular injury (MVI) despite angiographically successful primary percutaneous coronary intervention (PCI). We investigated whether hyperemic resistance (HMR) immediately after PCI predicts MVI at cardiovascular magnetic resonance and reduced blood flow positron emission tomography (PET).Sixty were included in this prospective study. Immediately PCI, intracoronary pressure-flow measurements performed...
Coronary function testing in patients with ischemia and nonobstructive coronary arteries (INOCA) commonly includes assessment of adenosine-mediated vasodilation acetylcholine spasm provocation. The purpose this study was to evaluate the diagnostic value additional endothelial for diagnosis vasomotor dysfunction INOCA.In retrospective cohort study, we included INOCA who underwent clinically indicated comprehensive testing. Endothelial defined as a <50% increase blood flow, determined by...