A5012711703- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Health and Mental Health
- Migraine and Headache Studies
- Coronary Artery Anomalies
- Cardiovascular Syncope and Autonomic Disorders
- Ultrasound and Hyperthermia Applications
- Cardiac pacing and defibrillation studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Olfactory and Sensory Function Studies
Amsterdam UMC Location Vrije Universiteit Amsterdam
2022-2025
Amsterdam Neuroscience
2022-2025
Amsterdam University Medical Centers
2022-2025
Vrije Universiteit Amsterdam
2022-2023
Abstract Migraine is a chronic neurovascular disease with complex, not fully understood pathophysiology multiple causes. People migraine suffer from recurrent moderate to severe headache attacks varying 4 72 h. The prevalence of two three times higher in women compared men. Importantly, it the most disabling <50 years age due high number lived disability, resulting very global socioeconomic burden. Robust evidence exists on association between aura and increased incidence...
Coronary function testing in patients with ischemia and nonobstructive coronary arteries (INOCA) commonly includes assessment of adenosine-mediated vasodilation acetylcholine spasm provocation. The purpose this study was to evaluate the diagnostic value additional endothelial for diagnosis vasomotor dysfunction INOCA.In retrospective cohort study, we included INOCA who underwent clinically indicated comprehensive testing. Endothelial defined as a <50% increase blood flow, determined by...
BackgroundAngina without angiographic evidence of obstructive coronary artery disease (ANOCA) is a highly prevalent condition with insufficient pathophysiological knowledge and lack evidence-based medical therapies. This affects ANOCA patients prognosis, their healthcare utilization quality life. In current guidelines, performing function test (CFT) recommended to identify specific vasomotor dysfunction endotype. The NetherLands registry invasive Coronary Function testing (NL-CFT) has been...
Abstract Introduction Stress perfusion cardiac magnetic resonance (CMR) effectively detects myocardial ischemia. In angina with non-obstructive coronary arteries (ANOCA), visually assessed first-pass often appears normal. Automated quantitative (QP) might benefit ANOCA diagnosis, offering absolute quantification of blood flow (MBF) and reserve (MPR). Aim We aimed to evaluate the efficacy QP in detecting ANOCA. Methods This study compared fully automated CMR patients age- sex-matched healthy...
Patients with angina and no obstructive coronary artery disease frequently have vasomotor dysfunction as underlying pathophysiological mechanism, comprising epicardial spasm, microvascular and/or microcirculatory dysfunction. These endotypes can be diagnosed by invasive function testing which has previously shown to safe in tertiary expert centers. To determine the prevalence of patients who were clinically referred for a test (CFT); assess safety feasibility CFT. This quality improvement...
(1) Background: Prevalence of patent foramen ovale (PFO) in the general population is estimated at around 24%. We hypothesized that right-to-left shunting (RLS) resulting from PFO might contribute to angina symptoms patients with coronary artery spasm (CAS), potentially triggered by vasoactive metabolites. Therefore, aim this study was investigate prevalence PFO-related RLS documented CAS. (2) Methods: This single-center prospective cohort included CAS undergoing transthoracic...
Coronary endothelial dysfunction (CED) and coronary artery spasm (CAS) are causes of angina in patients with no obstructive arteries (ANOCA). Both can be diagnosed by invasive function testing (ICFT) using Acetylcholine (ACh). This study aimed to evaluate the diagnostic yield a 3-minute ACh infusion as compared 1-minute bolus injection protocol CED CAS. In total 220 consecutive ANOCA underwent ICFT continuous Doppler flow measurements. Per protocol, 110 were tested thereafter injections, due...
Intracoronary acetylcholine (ACh) provocation is an established method for diagnosing epicardial and microvascular vasospasm in contemporary clinical practice. We hypothesize that ACh-induced followed by post-spastic reactive hyperemia (PSRH), which measured as increased flow-recovery time. To assess time, indicative of ischemia, among the diagnostic endotypes follow ACh testing. Patients with angina non-obstructive coronary artery disease on angiography who underwent testing were included...
Coronary pressure- and flow-derived parameters have prognostic value. This study aims to investigate the individual combined relevance of pressure flow reflecting resting hyperemic conditions. A total 1,971 vessels deferred from revascularization after invasive assessment were included international multicenter registry. Abnormal defined as distal coronary pressure/aortic ≤0.92 high (1/resting mean transit time >2.4 or average peak >22.7 cm/s), abnormal fractional reserve ≤0.80 low...
Background and aimsThe management of chronic coronary syndrome (CCS) is informed by studies predominantly including men. This study investigated the relationship between patients sex different endotypes CCS, sex-specific clinical outcomes.MethodsIn with CCS undergoing angiography, invasive Fractional Flow Reserve (FFR) Coronary (CFR) were measured. Patients stratified into groups: 1) obstructive artery disease (oCAD) (FFR≤0.80, no revascularization), 2) revascularization, 3) non-obstructive...
Vasoreactivity testing with high-dose acetylcholine is considered vasospasm provocation and low-dose as endothelial function testing.To assess the changes in reaction to low- endotypes of CAS defined by Coronary Vasomotor Disorders International Study Group (COVADIS) working group.Changes coronary epicardial diameter, blood flow (CBF) vascular resistance were determined at acetylcholine.A total 88 ANOCA patients included this analysis. In negative group (n = 14) incremental infusion produced...
We present 2 patients with angina no obstructive coronary artery disease and concomitant myocardial bridging. Despite maximal tolerated pharmacotherapy, symptoms remained. Invasive anatomical hemodynamic assessment identified bridging as a contributing cause of angina. Following heart team discussion, both underwent successful unroofing the left anterior descending artery.
Coronary vasomotor dysfunction, an important underlying cause of angina and non-obstructive coronary arteries (ANOCA), encompassing vasospasm, endothelial dysfunction and/or microvascular is clinically assessed by invasive function testing (ICFT). As ICFT imposes a high burden on patients carries risks, developing non-invasive alternatives important. We evaluated whether component systemic smooth muscle can be detected using laser speckle contrast analysis (LASCA).