A5071714475- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced MRI Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Peripheral Artery Disease Management
- Heart Rate Variability and Autonomic Control
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Coronary Artery Anomalies
- Infective Endocarditis Diagnosis and Management
- Phonocardiography and Auscultation Techniques
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Advancements in Photolithography Techniques
- Blood properties and coagulation
- Mechanical Circulatory Support Devices
- Sex and Gender in Healthcare
- Cerebrovascular and Carotid Artery Diseases
- Aortic Disease and Treatment Approaches
Aalborg University Hospital
2022-2025
Aarhus University Hospital
2012-2024
Helsinki University Hospital
2024
Copenhagen University Hospital
2024
Tampere University Hospital
2024
University of Copenhagen
2024
Skåne University Hospital
2024
Tampere University
2024
Heart Foundation
2024
Rigshospitalet
2024
Background Quantitative flow ratio ( QFR ) is a novel modality for physiological lesion assessment based on 3‐dimensional vessel reconstructions and contrast velocity estimates. We evaluated the value of online during routine invasive coronary angiography procedural feasibility, diagnostic performance, agreement with pressure‐wire–derived fractional reserve FFR as gold standard in an international multicenter study. Methods Results FAVOR II E‐J (Functional Assessment by Various Flow...
To evaluate the potential utility of a dual energy CT (DECT) scan in assessing urate deposits among patients with tophaceous gout, and obtain computerised quantification tophus volume peripheral joints.20 consecutive gout 10 control other arthritic conditions were included. DECT scans performed using renal stone colour-coding protocol that specifically assessed chemical composition material (ie, coloured red, calcium blue). An automated volumetric assessment was used to measure all joint...
Imaging-guided percutaneous coronary intervention (PCI) is associated with better clinical outcomes than angiography-guided PCI. Whether routine optical coherence tomography (OCT) guidance in PCI of lesions involving coronary-artery branch points (bifurcations) improves as compared angiographic uncertain. Download a PDF the Research Summary. We conducted multicenter, randomized, open-label trial at 38 centers Europe. Patients indication for and complex bifurcation lesion identified by means...
Background: Coronary microvascular dysfunction (CMD) is an important contributor to angina syndromes.Recently, two distinct endotypes were identified using combined assessment of coronary flow reserve (CFR) and minimal resistance (MR), termed structural functional CMD. Aims:We aimed assess the relevance CFR MR in patients with no obstructive arteries.Methods: Patients chronic syndromes (CCS) non-obstructive artery disease (fractional [FFR] ≥0.80) selected (N=1,102).Functional CMD was defined...
The microvascular resistance reserve (MRR) was introduced as a means to characterize the vasodilator capacity of coronary microcirculation while accounting for influence concomitant epicardial disease and impact administration potent vasodilators on aortic pressure. This study aimed evaluate diagnostic prognostic performance MRR.A total 1481 patients with stable symptoms clinical indication angiography were included from global ILIAS Registry. MRR derived function flow (CFR) divided by...
BackgroundThe benefit of percutaneous coronary intervention (PCI) in patients with stable artery disease and severe aortic stenosis who are undergoing transcatheter aortic-valve implantation (TAVI) remains unclear.MethodsIn an international trial, we randomly assigned, a 1:1 ratio, symptomatic at least one coronary-artery fractional flow reserve 0.80 or less diameter 90% either to undergo PCI receive conservative treatment, all also TAVI. The primary end point was major adverse cardiac...
BACKGROUND: Diffuse coronary artery disease affects the safety and efficacy of percutaneous intervention (PCI). Pathophysiologic patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating pullback pressure gradient (PPG) calculation. This study aimed to establish capacity PPG predict optimal revascularization procedural outcomes. METHODS: prospective, investigator-initiated, single-arm, multicenter enrolled patients with at least one epicardial lesion an FFR ≤0.80...
Clinical outcomes following coronary computed tomography–derived fractional flow reserve (FFRCT) testing in clinical practice are unknown. This study sought to assess real-world a diagnostic strategy including first-line tomography angiography (CTA) with selective FFRCT testing. The reviewed the results of 3,674 consecutive patients stable chest pain evaluated CTA and guide downstream management intermediate stenosis (30% 70%). composite endpoint (all-cause death, myocardial infarction,...
Background In the absence of obstructive coronary stenoses, abnormality noninvasive stress tests (NIT) in patients with chronic syndromes may indicate myocardial ischemia nonobstructive arteries (INOCA). The differential prognosis INOCA according to presence microvascular dysfunction (CMD) and incremental prognostic value CMD intracoronary physiologic assessment on top NIT information remains unknown. Methods Results From international multicenter registry (ILIAS [Inclusive Invasive...
In patients with increased bleeding risk, the biolimus A9-coated BioFreedom stent, a stainless steel drug-coated stent free from polymer, has shown superiority compared bare-metal stent. The aim of this study was to investigate whether is noninferior modern ultrathin strut biodegradable polymer cobalt-chromium sirolimus-eluting Orsiro in an all-comers patient population treated percutaneous coronary intervention.The SORT OUT IX trial (Scandinavian Organization for Randomized Trials With...
Abstract Objectives We evaluated the diagnostic performance of quantitative flow ratio (QFR) assessment nonculprit lesions (NCLs) based on acute setting angiograms obtained in patients with ST‐segment elevation myocardial infarction (STEMI) QFR, fractional reserve (FFR), and instantaneous wave‐free (iFR) staged as reference. Background QFR is an angiography‐based approach for functional evaluation coronary artery lesions. Methods This was a post‐hoc analysis iSTEMI study. NCLs were assessed...
Background As younger patients are being considered for transcatheter aortic valve implantation (TAVI), the assessment and treatment of concomitant coronary artery disease is taking on increased importance. Methods Results Thirteen contemporary lower‐risk with TAVI severe stenosis (AS) moderate‐severe lesions were included. Patients underwent hemodynamics in presence AS (pre‐ ), absence (immediately post‐ at longer‐term follow‐up (6 months ). Fractional flow reserve decreased from 0.85...
Background: Quantitative flow ratio (QFR) is a tool for physiological lesion assessment based on invasive coronary angiography. Aims:We aimed to assess the reproducibility of QFR computed from same angiograms as assessed by multiple observers different, international sites.Methods: We included 50 patients previously enrolled in dedicated studies.QFR was twice, one month apart five blinded observers.The main analysis coefficient variation (CV) measure intra-and inter-observer...
Background: Target lesion failure remains an issue with contemporary drug-eluting stents. Thus, the dual-therapy sirolimus-eluting and CD34+ antibody–coated Combo stent (DTS) was designed to further improve early healing. This study aimed investigate whether DTS is noninferior Orsiro (SES) in all-comers patient population. Methods: The SORT OUT X (Combo Stent Versus Stent) trial, a large-scale, randomized, multicenter, single-blind, 2-arm, noninferiority trial registry-based follow-up....
OBJECTIVES The aim of this study was to assess clinical outcomes after combined pressure and flow assessment coronary lesions.BACKGROUND Although fractional reserve (FFR) remains the invasive reference standard for revascularization, approximately 40% stenoses have discordant (CFR).Optimal treatment these disagreements unclear.METHODS A total 455 subjects with 668 lesions were enrolled from 12 sites in 6 countries.Only reduced FFR CFR underwent revascularization; all other combinations...
ABSTRACT Background Chronic coronary total occlusions (CTO) represent a therapeutic challenge, and results of randomized clinical trials observational studies comparing conservative treatment versus percutaneous intervention (PCI) are underpowered. Aims To assess myocardial infarction (MI) all‐cause mortality in consecutive patients with CTO lesions. Methods Using data from the West Denmark Heart Registry, chronic syndrome 100% occluded vessel by invasive angiography (ICA) were identified....
Chronic total occlusions (CTO) are frequent among patients with coronary artery disease. Revascularization percutaneous intervention (PCI) is safe and feasible in experienced hands. However, randomized data needed to demonstrate symptomatic as well prognostic effect of CTO-PCI compared optimal medical therapy alone.This trial aims evaluate the CTO PCI a lesion target vessel diameter ≥ 2.5 mm, myocardial ischemia relevant territory. First, all subjected (OMT) for at least 3 months non-CTO...