Jozef Bartúnek
A5038774828- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Tissue Engineering and Regenerative Medicine
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Transplantation: Methods and Outcomes
- Mesenchymal stem cell research
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Fibrosis and Remodeling
- Cardiovascular Disease and Adiposity
- Nitric Oxide and Endothelin Effects
- Electrospun Nanofibers in Biomedical Applications
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Cardiac and Coronary Surgery Techniques
Onze Lieve Vrouwziekenhuis Hospital
2016-2025
Cardiovascular Research Center
2018-2025
Flanders Environment Agency
2007-2024
University of Oxford
2024
Fujita Health University
2023
Centro Cardiologico Monzino
2023
University of Alberta
2013-2021
Hartcentrum Hasselt
2021
Jessa Hospital
2021
Lutheran Medical Group
2021
The clinical significance of coronary-artery stenoses moderate severity can be difficult to determine. Myocardial fractional flow reserve (FFR) is a new index the functional coronary that calculated from pressure measurements made during arteriography. We compared this with results noninvasive tests commonly used detect myocardial ischemia, determine usefulness index.
Poland), and Katja Zeppenfeld (
Background —PTCA of a coronary stenosis without documented ischemia at noninvasive stress testing is often performed, but its benefit unproven. Coronary pressure–derived fractional flow reserve (FFR) an invasive index severity that reliable substitute for testing. A value 0.75 identifies stenoses with hemodynamic significance. Methods and Results —In 325 patients whom PTCA was planned who did not have ischemia, FFR the measured. If >0.75, were randomly assigned to deferral (deferral...
Background Coronary arteries without focal stenosis at angiography are generally considered non–flow-limiting. However, atherosclerosis is a diffuse process that often remains invisible angiography. Accordingly, we hypothesized in patients with coronary artery disease, nonstenotic induce decrease pressure along their length due to atherosclerosis. Methods and Results fractional flow reserve (FFR), as indices of conductance, were obtained from 37 10 individuals (group I) 106 62 arteriographic...
Background— Bone marrow CD133-postive (CD133 + ) cells possess high hematopoietic and angiogenic capacity. We tested the feasibility, safety, functional effects of use enriched CD133 progenitor after intracoronary administration in patients with recent myocardial infarction. Methods Results— Among 35 acute infarction treated stenting, 19 underwent (12.6±2.2×10 6 cells) 11.6±1.4 days later (group 1) 16 did not 2). At 4 months, left ventricular ejection fraction increased significantly group 1...
Background To assess coronary lesion severity in the catheterization laboratory, several guide wire–based methods have been proposed. The purpose of present study was to compare feasibility and reproducibility flow velocity reserve (CFVR), instantaneous hyperemic diastolic velocity-pressure slope index (IHDVPS), pressure-derived myocardial fractional (FFR myo ). Methods Results From distal pressure signals (0.014-in wires), CFVR, IHDVPS, FFR were computed 15 stenoses (13 patients) under four...
Background— Cardiac resynchronization therapy was shown to reverse left ventricular (LV) remodeling in patients with congestive heart failure (CHF). However, the prediction of benefit is controversial. We aimed investigate predictive factors LV functional recovery and reversed after biventricular pacing. Methods Results— Forty-nine consecutive CHF a wide QRS complex (182±32 ms) were studied by echocardiography before resynchronization. Intraventricular interventricular asynchrony their...
The appropriate duration of dual antiplatelet therapy in patients at high risk for bleeding after the implantation a drug-eluting coronary stent remains unclear.
Significant left main coronary artery stenosis is an accepted indication for surgical revascularization. The potential of angiography to evaluate the hemodynamic severity a limited. aims present study were assess long-term clinical outcome patients with angiographically equivocal in whom revascularization strategy was based on fractional flow reserve (FFR) and determine relationship between quantitative FFR.In 213 stenosis, FFR measurements performed. When > or =0.80, treated medically...
The present analysis addresses the potential clinical and physiologic significance of discordance in severity coronary artery disease between angiogram fractional flow reserve (FFR) a large unselected patient population. Between September 1999 December 2011, FFR percent diameter stenosis (DS) as assessed by quantitative angiography were obtained 2986 patients (n = 4086 stenoses), whom at least one was intermediate angiographic severity. Fractional correlated slightly but significantly with...
Background— In the Apixaban for Reduction in Stroke and Other Thromboembolic Events Atrial Fibrillation (ARISTOTLE) trial, apixaban compared with warfarin reduced stroke systemic embolism, major bleeding, mortality. We evaluated treatment effects relation to 2 predictions of time therapeutic range (TTR). Methods Results— The trial randomized 18 201 patients atrial fibrillation 5 mg twice daily or at least 12 months. For each patient, a center average TTR was estimated use linear mixed model...
Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem have shown preliminary efficacy. The Congestive Heart Failure Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort.
Abstract Aims A majority of acute coronary syndromes (ACS) present without typical ST elevation. One-third non–ST-elevation myocardial infarction (NSTEMI) patients have an acutely occluded culprit artery [occlusion (OMI)], leading to poor outcomes due delayed identification and invasive management. In this study, we sought develop a versatile artificial intelligence (AI) model detecting OMI on single-standard 12-lead electrocardiograms (ECGs) compare its performance with existing...
Abstract Background and Aims The question of when how to treat truly asymptomatic patients with severe aortic stenosis (AS) normal left ventricular (LV) systolic function is still subject debate ongoing research. Here, the results extended follow-up AVATAR trial are reported (NCT02436655, ClinicalTrials.gov). Methods randomly assigned severe, AS LV ejection fraction ≥ 50% undergo either early surgical valve replacement (AVR) or conservative treatment watchful waiting strategy. All had...
BACKGROUND: Diffuse coronary artery disease affects the safety and efficacy of percutaneous intervention (PCI). Pathophysiologic patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating pullback pressure gradient (PPG) calculation. This study aimed to establish capacity PPG predict optimal revascularization procedural outcomes. METHODS: prospective, investigator-initiated, single-arm, multicenter enrolled patients with at least one epicardial lesion an FFR ≤0.80...
Background — Fractional flow reserve (FFR), an index of coronary stenosis severity, can be calculated from the ratio hyperemic distal to proximal pressure. An FFR value 0.75 distinguish patients with normal and abnormal noninvasive stress testing in case left ventricular function. The present study aimed at investigating a prior myocardial infarction. Methods Results In 57 who had sustained infarction ≥6 days earlier, perfusion single photon emission scintigraphy (SPECT) imaging were...
Background— Inducing both maximal and steady-state coronary hyperemia is of clinical importance to take full advantage fractional flow reserve measurements. The present study compares different dosages routes administration adenosine 5′-triphosphate (ATP), adenosine, contrast medium, papaverine regarding their potential achieve hyperemia. Methods Results— In 21 patients with an isolated stenosis, vasodilation was induced successively by (20 mg intracoronary), 40 μg ATP iohexol (6 mL or...
Background — Guide wire–based simultaneous measurement of fractional flow reserve (FFR) and coronary (CFR) is important to understand microvascular disease the heart. The aim this study was investigate feasibility FFR CFR by one pressure-temperature sensor-tipped guide wire with use thermodilution compare (CFR thermo ) simultaneously measured Doppler Doppl ). Methods Results In 103 arteries in 50 patients, a 0.014-inch floppy were introduced. Both normal vessels wide range stenotic included....