Toshiro Shinke
A5003215238- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Peripheral Artery Disease Management
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Pulmonary Hypertension Research and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Aortic aneurysm repair treatments
- Cardiovascular and Diving-Related Complications
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Atrial Fibrillation Management and Outcomes
- Optical Coherence Tomography Applications
- Cardiac pacing and defibrillation studies
- Vascular Procedures and Complications
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Aortic Thrombus and Embolism
- Atherosclerosis and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
Showa University
2018-2025
Ijinkai Takeda General Hospital
2021-2024
Showa University Hospital
2018-2023
Shibuya University Network
2020-2023
Onze Lieve Vrouwziekenhuis Hospital
2023
Japan Association for Diabetes Education and Care
2019-2022
Kobe University
2012-2021
Saiseikai Yokohama Eastern Hospital
2015-2020
Ministry of Health Labour and Welfare
2020
Kobe University Hospital
2016
The purpose of this document is to make the output International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available medical scientific communities, through a peer-reviewed publication, in interest improving diagnosis treatment patients with atherosclerosis, including coronary artery disease. optical coherence tomography (IVOCT) catheter-based modality that acquires images at resolution ∼10 μm, enabling visualization blood vessel...
BACKGROUND: Diffuse coronary artery disease affects the safety and efficacy of percutaneous intervention (PCI). Pathophysiologic patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating pullback pressure gradient (PPG) calculation. This study aimed to establish capacity PPG predict optimal revascularization procedural outcomes. METHODS: prospective, investigator-initiated, single-arm, multicenter enrolled patients with at least one epicardial lesion an FFR ≤0.80...
Abstract Cardiovascular interventions have achieved a level of excellence, with many outstanding advanced techniques and results. The mission the Japanese Association Intervention Therapeutics (CVIT) is to further our understanding cardiovascular intervention establish its procedural safety. [1] Percutaneous Coronary (J-PCI) registry was established sponsored by CVIT, aims provide basic statistics on performance percutaneous coronary (PCI) in Japan. Today, database has grown become one...
Adverse plaque characteristics (APCs) by coronary computed tomography (CT) angiography (CTA) are associated with myocardial ischaemia and future acute syndromes. The overall objective was to determine whether APCs on non-invasive CTA vulnerable features invasive optical coherence (OCT). Sixty-eight plaques in 45 patients were evaluated OCT. were: positive remodelling (PR), index ≥1.10; low attenuation (LAP), any intraplaque voxel <30 Hounsfield units; spotty calcification (SC), ≤3 mm;...
Abstract A previous report showed that the consumption of glutathione through oxidative stress activates synthetic pathway, which is accompanied by production ophthalmic acid from 2-aminobutyric (2-AB). We conducted a comprehensive quantification serum metabolites using gas chromatography-mass spectrometry in patients with atrial septal defect to find clues for understanding myocardial metabolic regulation, and demonstrated circulating 2-AB levels reflect hemodynamic changes. However,...
The interplay between coronary hemodynamics and plaque characteristics remains poorly understood.The aim of this study was to compare atherosclerotic phenotypes focal diffuse artery disease (CAD) defined by hemodynamics.This multicenter, prospective, single-arm conducted in 5 countries. Patients with functionally significant lesions based on an invasive fractional flow reserve ≤0.80 were included. Plaque analysis performed using computed tomography angiography optical coherence tomography....
Objective— NADH/NADPH oxidase is an important source of reactive oxygen species (ROS) in the vasculature. Recently, we demonstrated that p22 phox , essential component this oxidase, was expressed human coronary arteries and its expression enhanced with progression atherosclerosis. The present study undertaken to investigate functional importance pathogenesis artery disease. For aim, distribution oxidized low density lipoprotein (LDL), generation ROS directional atherectomy (DCA) specimens...
The neurotrophin (NT) family, including nerve growth factor NT-3 and brain-derived neurotrophic (BDNF), has a critical role in the survival, growth, maintenance, death of central peripheral neurons. NTs their receptors are expressed atherosclerotic lesions; however, significance cardiovascular disease remains unclear.To clarify pathogenesis coronary artery disease, NT plasma levels aorta, sinus, veins patients with unstable angina (n=38), stable effort (n=45), non-coronary (n=24) were...
The authors sought to clarify how intravascular ultrasound (IVUS) and optical coherence tomography affect percutaneous coronary intervention (PCI) with current-generation drug-eluting stents in a pre-specified substudy of the OPINION (OPtical frequency domain imaging versus INtravascular interventiON) trial, multicenter, prospective, randomized, noninferiority trial comparing (OFDI)-guided PCI IVUS-guided PCI.The impact these 2 modalities guiding remains unknown.Of 829 patients enrolled 106...
Background:In patients with acute coronary syndrome (ACS), alirocumab reduced the risk of recurring ischemic events. ODYSSEY J-IVUS assessed effect on atheroma volume in Japanese recently hospitalized ACS and hypercholesterolemia, using intravascular ultrasound imaging analysis.