A5079746110- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Aortic aneurysm repair treatments
- Acute Myocardial Infarction Research
- Vascular Procedures and Complications
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Coronary Artery Anomalies
- Aortic Disease and Treatment Approaches
- Cardiovascular Issues in Pregnancy
- Central Venous Catheters and Hemodialysis
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Rheology and Fluid Dynamics Studies
- Organ Transplantation Techniques and Outcomes
- Peripheral Artery Disease Management
- Wind and Air Flow Studies
- Masonry and Concrete Structural Analysis
- Caveolin-1 and cellular processes
- Hemodynamic Monitoring and Therapy
- Kawasaki Disease and Coronary Complications
Polytechnic University of Turin
2018-2025
Vall d'Hebron Institut de Recerca
2022
Instituto de Salud Carlos III
2022
Centro de Investigación en Red en Enfermedades Cardiovasculares
2022
The combination of medical imaging and computational hemodynamics is a promising technology to diagnose/prognose coronary artery disease (CAD). However, the clinical translation in silico hemodynamic models still hampered by assumptions/idealizations that must be introduced model-based strategies necessarily imply uncertainty. This study aims provide definite answer open question how properly model blood rheological properties fluid dynamics (CFD) simulations hemodynamics.The geometry right...
Coronary artery ectasias and aneurysms (CAE/CAAs) are among the less common forms of coronary disease, with undefined long-term outcomes treatment strategies. To assess clinical characteristics, angiographic patterns, in patients CAE, CAA, or both. This 15-year (2006-2021) retrospective single-centre registry included 281 diagnosed CAE/CAA via invasive angiography. Major adverse cardiovascular events all-cause death, non-fatal myocardial infarction, unplanned ischaemia-driven...
Background Coronary microvascular dysfunction has been associated with adverse cardiovascular events following acute myocardial infarction. This study evaluates the role of angiography‐derived index microcirculatory resistance (angio‐IMR) in predicting damage patients ST‐segment–elevation infarction undergoing primary percutaneous coronary intervention (PCI). Methods and Results In this post hoc analysis CLEVER‐ACS (Controlled‐Level Everolimus Acute Syndromes) trial, associations between...
A marked interest has recently emerged regarding the analysis of wall shear stress (WSS) vector field topological skeleton in cardiovascular flows. Based on dynamical system theory, WSS is composed fixed points, i.e., focal points where locally vanishes, and unstable/stable manifolds, consisting contraction/expansion regions linking points. Such an arises from its ability to reflect presence near-wall hemodynamic features associated with onset progression vascular diseases. Over years,...
Despite the important advancements in stent technology for treatment of diseased coronary arteries, major complications still affect postoperative long-term outcome. The stent-induced flow disturbances, and especially altered wall shear stress (WSS) profile at strut level, play an role pathophysiological mechanisms leading to thrombosis (ST) in-stent restenosis (ISR). In this context, analysis WSS topological skeleton is gaining more interest by extending current understanding association...
Abstract The present study establishes a link between blood flow energy transformations in coronary atherosclerotic lesions and clinical outcomes. predictive capacity for future myocardial infarction (MI) was compared with that of established quantitative angiography (QCA)-derived predictors. Angiography-based computational fluid dynamics (CFD) simulations were performed on 80 human culprit MI within 5 years 108 non-culprit MI. Blood assessed the converging segment lesion as ratios kinetic...
Endovascular aneurysm repair (EVAR) has disseminated rapidly as an alternative to open surgical for the treatment of abdominal aortic aneurysms (AAAs), because its reduced invasiveness, low mortality, and morbidity rate. The effectiveness endovascular devices used in EVAR is always at question postoperative adverse events can lead re-intervention or a possible fatal scenario circulatory system. Motivated by assessment risks related thrombus formation, here impact two different commercial...
Spontaneous coronary artery dissection (SCAD) is an increasingly diagnosed cause of myocardial infarction with unclear pathophysiology. The aim the study was to test if vascular segments site SCAD present distinctive local anatomy and hemodynamic profiles.Coronary arteries spontaneously healed (confirmed by follow-up angiography) underwent three-dimensional reconstruction, morphometric analysis definition vessel curvature torsion, computational fluid dynamics (CFD) simulations derivation...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> The need for distilling the hemodynamic complexity of aortic flows into clinically relevant quantities resulted in a loss information hidden 4D fluid structures. To reduce loss, this study proposes network-based approach to identify and characterize vivo large-scale coherent motion blood healthy human aorta. xmlns:xlink="http://www.w3.org/1999/xlink">Methods:</i> quantitative...
Abstract This study focuses on identifying anatomical markers with predictive capacity for long-term myocardial infarction (MI) in focal coronary artery disease (CAD). Eighty future culprit lesions (FCL) and 108 non-culprit (NCL) from 80 patients underwent 3D quantitative angiography. The minimum lumen area (MLA), ratio (MLR), vessel fractional flow reserve (vFFR) were evaluated. MLR was defined as the between MLA cross-sectional at proximal lesion edge, lower values indicating more abrupt...
The evidence on the role of hemodynamics in aorta pathophysiology has yet to be robustly translated into clinical applications, improve risk stratification aortic diseases. Motivated by need enrich current understanding ascending (AAo), this study evaluates vivo how large-scale flow coherence is affected AAo dilation and valve phenotype.
<p><strong>Objective</strong>: The need for distilling the hemodynamic complexity into clinically relevant quantities has imposed a reductionist approach to investigate aortic flows, resulting in lossy compression of information hidden 4D fluid structures. Aiming at reducing loss, this study proposes network-based identify and characterize vivo large-scale coherent motion blood healthy human aorta using Flow MRI. <strong>Methods</strong>: Adopting quantitative...