A5091431404- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Vascular Procedures and Complications
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Elasticity and Material Modeling
- Caveolin-1 and cellular processes
- Topology Optimization in Engineering
- Advanced Neuroimaging Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Pluripotent Stem Cells Research
- Masonry and Concrete Structural Analysis
- Building Energy and Comfort Optimization
- Total Knee Arthroplasty Outcomes
Polytechnic University of Turin
2016-2024
Erasmus University Rotterdam
2020
Erasmus MC
2020
Abstract Aims Atherosclerotic plaque development has been associated with wall shear stress (WSS). However, the multidirectionality of blood flow, and thus WSS, is rarely taken into account. The purpose this study was to comprehensively compare five metrics that describe (multidirectional) WSS behaviour assess how affects coronary initiation progression. Methods results Adult familial hypercholesterolaemic pigs (n = 10) were fed a high-fat diet, underwent imaging three main arteries at...
Abstract Although unphysiological wall shear stress (WSS) has become the consensus hemodynamic mechanism for coronary atherosclerosis, complex biomechanical stimulus affecting atherosclerosis evolution is still undetermined. This motivated interest on contraction/expansion action exerted by WSS endothelium, obtained through topological skeleton analysis. study tests ability of this feature, alone or combined with magnitude, to predict thickness (WT) longitudinal changes. Nine arteries...
The combination of medical imaging and computational hemodynamics is a promising technology to diagnose/prognose coronary artery disease (CAD). However, the clinical translation in silico hemodynamic models still hampered by assumptions/idealizations that must be introduced model-based strategies necessarily imply uncertainty. This study aims provide definite answer open question how properly model blood rheological properties fluid dynamics (CFD) simulations hemodynamics.The geometry right...
In the context of aortic hemodynamics, uncertainties affecting blood flow simulations hamper their translational potential as supportive technology in clinics. Computational fluid dynamics (CFD) under rigid-walls assumption are largely adopted, even though aorta contributes markedly to systemic compliance and is characterized by a complex motion. To account for personalized wall displacements hemodynamics simulations, moving-boundary method (MBM) has been recently proposed computationally...
BACKGROUND: Plaque composition and wall shear stress (WSS) magnitude act as well-established players in coronary plaque progression. However, WSS per se does not completely capture the mechanical stimulus to which endothelium is subjected, since endothelial cells experience changes spatiotemporal configuration on luminal surface. This study explores profile lipid content signatures of progression identify novel biomarkers atherosclerosis. METHODS: Thirty-seven patients with acute syndrome...
Abstract Wall Shear Stress (WSS) topological skeleton, composed by fixed points and the manifolds linking them, reflects presence of blood flow features associated to adverse vascular response. However, influence WSS skeleton on pathophysiology is still underexplored. This study aimed identify direct associations between markers disease from real-world clinical longitudinal data long-term restenosis after carotid endarterectomy (CEA). Personalized computational hemodynamic simulations were...
In this study, we propose a novel computational framework for designing innovative self-expandable femoral stents. First, two-dimensional stent unit cell is designed by inverse homogenization topology optimization. particular, the optimized in terms of contact area with target matching prescribed mechanical properties. The optimization enriched an anisotropic mesh adaptation strategy, enabling time- and cost-effective procedure that promotes original layouts. Successively, periodically...
Wall shear stress (WSS), the frictional force of blood on vessel wall, plays a crucial role in atherosclerotic plaque development. Low WSS has been associated with growth, however previous research used different approaches to define low investigate its effect progression. In this study, we four methodologies allocate low, mid and high one dataset human coronary arteries investigated predictive power for Coronary reconstructions were based multimodality imaging, using intravascular...
A marked interest has recently emerged regarding the analysis of wall shear stress (WSS) vector field topological skeleton in cardiovascular flows. Based on dynamical system theory, WSS is composed fixed points, i.e., focal points where locally vanishes, and unstable/stable manifolds, consisting contraction/expansion regions linking points. Such an arises from its ability to reflect presence near-wall hemodynamic features associated with onset progression vascular diseases. Over years,...
Despite the important advancements in stent technology for treatment of diseased coronary arteries, major complications still affect postoperative long-term outcome. The stent-induced flow disturbances, and especially altered wall shear stress (WSS) profile at strut level, play an role pathophysiological mechanisms leading to thrombosis (ST) in-stent restenosis (ISR). In this context, analysis WSS topological skeleton is gaining more interest by extending current understanding association...
Abstract Aims Low wall shear stress (WSS) is acknowledged to play a role in plaque development through its influence on local endothelial function. Also, lipid-rich plaques (LRPs) are associated with dysfunction. However, little known about the interplay between WSS and presence of lipids respect progression. Therefore, we aimed study differences WSS-related progression LRPs, non-LRPs, or plaque-free regions human coronary arteries. Methods results In present single-centre, prospective...
Coronary atherosclerosis is a leading cause of illness and death in Western World its mechanisms are still non completely understood. Several animal models have been used to 1) study coronary natural history 2) propose predictive tools for this disease, that asymptomatic long time, aiming direct translation their findings human arteries. Among them, swine largely due the observed anatomical pathophysiological similarities humans. However, comparison between terms hemodynamics, known...
High wall shear stress (WSS) and near-infrared spectroscopy (NIRS) detected lipid-rich plaque (LRP) are both known to be associated with destabilization future adverse cardiovascular events. However, knowledge of spatial co-localization LRP high WSS is lacking. This study investigated the based on NIRS WSS. Fifty-three patients presenting acute coronary syndrome underwent NIRS-intravascular-ultrasound (NIRS-IVUS) imaging a non-culprit artery. was obtained using profiling in...
Atherosclerosis at the early stage in coronary arteries has been associated with low cycle-average wall shear stress magnitude. However, parallel to identification of an established active role for onset/progression atherosclerotic disease, a weak association between lesions localization and low/oscillatory observed. In attempt fully identify phenotype triggering atherosclerosis arteries, this exploratory study aims enriching characterization emerging features combining correlation-based...
This work investigates the effect that application of intermittent pneumatic compression to lower limbs has on cardiovascular system. Intermittent can be applied subjects with reduced or null mobility and useful for therapeutic purposes in sports recovery, deep vein thrombosis prevention lymphedema drainage. However, performance effectiveness are often difficult predict. study presents a reduced-order numerical model interaction between system device. The different operating conditions have...