A5075035084- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiac Health and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- T-cell and B-cell Immunology
- Connective Tissue Growth Factor Research
- Systemic Lupus Erythematosus Research
- Atrial Fibrillation Management and Outcomes
- Fatty Acid Research and Health
- Inflammasome and immune disorders
- Biomarkers in Disease Mechanisms
- Pharmaceutical Economics and Policy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Function and Risk Factors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- Circular RNAs in diseases
University of Zurich
2013-2025
Kerckhoff Klinik
2015-2025
Justus-Liebig-Universität Gießen
2020-2025
German Centre for Cardiovascular Research
2017-2024
University Hospital of Zurich
2014-2023
Imperial College London
2018-2022
University Hospital of Bern
2016-2022
University of Bern
2022
Centre universitaire de médecine générale et santé publique, Lausanne
2022
University of Lausanne
2015-2022
The aim was to study the prognostic value of plasma ceramides (Cer) as cardiovascular death (CV death) markers in three independent coronary artery disease (CAD) cohorts.Corogene is a prospective Finnish cohort including stable CAD patients (n = 160). Multiple lipid biomarkers and C-reactive protein were measured addition Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0), Cer(d18:1/24:1). Subsequently, association between high-risk CV mortality investigated Special Program University...
Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism dietary (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary secondary prevention subjects. However, the prognostic value TMAO setting acute coronary syndromes (ACS) remains unknown.We investigated relationship with among sequential patients presenting ACS two independent cohorts. In...
Atherosclerosis is a chronic inflammatory disease promoted by hyperlipidemia. Several studies support FOXP3-positive regulatory T cells (Tregs) as inhibitors of atherosclerosis; however, the mechanism underlying this protection remains elusive. To define role FOXP3-expressing Tregs in atherosclerosis, we used DEREG mouse, which expresses diphtheria toxin (DT) receptor under control Treg-specific Foxp3 promoter, allowing for specific ablation FOXP3+ Tregs. Lethally irradiated,...
Acute cardiogenic shock after myocardial infarction is associated with high in-hospital mortality attributable to persisting low-cardiac output. The Impella-EUROSHOCK-registry evaluates the safety and efficacy of Impella-2.5-percutaneous left-ventricular assist device in patients acute infarction.This multicenter registry retrospectively included 120 (63.6±12.2 years; 81.7% male) from receiving temporary circulatory support device. primary end point evaluated at 30 days. secondary analyzed...
Abstract Aims The respective roles of oral anticoagulation or antiplatelet therapy following transcatheter aortic valve implantation (TAVI) remain debated. ATLANTIS is an international, randomized, open-label, superiority trial comparing apixaban to the standard care. Methods and results After successful TAVI, 1500 patients were randomized (1:1) receive 5 mg (2.5 if impaired renal function concomitant therapy) (n = 749) twice daily, care 751). Randomization was stratified by need for chronic...
Atherosclerosis is an inflammatory disease. Autoimmune responses to low-density lipoproteins (LDL) contribute its progression, whereas immunization with LDL may induce atheroprotective or proatherogenic responses. The objective of this study was develop vaccine by targeting a peptide the protein constituent apolipoprotein B-100 (apoB-100) nasal mucosa protective mucosal immune response.A comprising amino acids 3136 3155 apoB-100 (p210) fused B subunit cholera toxin (CTB), which binds...
We aimed to assess the prevalence and management of clinical familial hypercholesterolaemia (FH) among patients with acute coronary syndrome (ACS). studied 4778 ACS from a multi-centre cohort study in Switzerland. Based on personal history premature cardiovascular disease LDL-cholesterol levels, two validated algorithms for diagnosis FH were used: Dutch Lipid Clinic Network algorithm possible (score 3–5 points) or probable/definite (>5 points), Simon Broome Register FH. At time...
Proprotein convertase subtilisin kexin 9 (PCSK9) is an emerging target for the treatment of hypercholesterolaemia, but clinical utility PCSK9 levels to guide unknown. We aimed prospectively assess prognostic value plasma in patients with acute coronary syndromes (ACS). Plasma were measured 2030 ACS undergoing angiography a Swiss prospective cohort. At 1 year, association between tertiles and all-cause death was assessed adjusting Global Registry Acute Coronary Events (GRACE) variables, as...
Patients with heterozygous familial hypercholesterolemia (FH) and coronary heart disease have high mortality rates. However, in an era of high-dose statin prescription after acute syndrome (ACS), the risk recurrent cardiovascular events associated FH might be mitigated. We compared event rates between patients without ACS.We studied 4534 ACS enrolled a multicenter, prospective cohort study Switzerland 2009 2013 who were individually screened for on basis clinical criteria according to 3...
MicroRNAs (miRNA) are important non-coding modulators controlling patterns of gene expression. However, profiling and validation circulating miRNA levels related to adverse cardiovascular outcome has not been performed in patients with an acute coronary syndrome (ACS).In a multicentre, prospective ACS cohort, 1002 out 2168 presented ST-segment elevation myocardial infarction (STEMI). Sixty-three STEMI experienced adjudicated major event (MACE, defined as cardiac death or recurrent...
Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of angiotensin II which disturbs peripheral blood pressure regulation and compromises left ventricular function. This study examined relationship circulating DPP3 (cDPP3) with cardiogenic shock (CS) mortality patients presenting acute coronary syndromes (ACS).Plasma cDPP3 levels were assessed at baseline 12-24 h after presentation ACS prospectively enrolled into multi-centre SPUM-ACS (n = 4787).Circulating associated...
Clinical scores and biomarkers improve risk stratification of patients with acute coronary syndromes. However, little is known about their value in referred for angiography.Consecutive admitted at four Swiss university hospitals a diagnosis syndrome were enrolled into the SPUM-ACS Biomarker Cohort between 2009 2012. Patients followed 30 days 1 year assessment adjudicated events including all-cause mortality composite or non-fatal recurrent myocardial infarction.Events analysed 1892 (52.4%...
Background Coronary microvascular dysfunction has been associated with adverse cardiovascular events following acute myocardial infarction. This study evaluates the role of angiography‐derived index microcirculatory resistance (angio‐IMR) in predicting damage patients ST‐segment–elevation infarction undergoing primary percutaneous coronary intervention (PCI). Methods and Results In this post hoc analysis CLEVER‐ACS (Controlled‐Level Everolimus Acute Syndromes) trial, associations between...
Epidemiological studies report an inverse association between plant-derived dietary α-linolenic acid (ALA) and cardiovascular events. However, little is known about the mechanism of this protection. We assessed cellular molecular mechanisms ALA (flaxseed) on atherosclerosis in a mouse model.Eight-week-old male apolipoprotein E knockout (ApoE(-/-)) mice were fed 0.21 % (w/w) cholesterol diet for 16 weeks containing either high [7.3 (w/w); n = 10] or low content [0.03 10]. Bioavailability,...
Regulatory T cells (Treg) exert anti-inflammatory and atheroprotective effects in experimental atherosclerosis. Treg can be induced against specific antigens using immunization strategies associated with clonal restriction. No data exist on combination restriction of patients acute coronary syndromes (ACS). Among cell subsets characterized by flow cytometry, (CD4+ CD25+ CD127low) were twice as frequent thrombi compared peripheral blood. prevailed among identified thrombi. To evaluate...
Objectives To assess the association between intensity of statin therapy and level physical activity in patients 1 year after an acute coronary syndrome (ACS). Design Prospective cohort study from Special Program University Medicine-Acute Coronary Syndromes. Setting Four university hospital centres Switzerland. Participants 2274 with a main diagnosis ACS 2009 2017 who were available for 1-year follow-up visit discharge. Outcome measures Self-reported was assessed International Physical...
Abstract Despite substantial advances in cardiovascular pharmacotherapy and devices recent years, prevention treatment of many diseases (CVD) remain limited, thus reflecting the need for more effective safer pharmacological strategies. In this review, we summarize most relevant studies 2024, including approval first-in-class drugs resistant hypertension pulmonary arterial hypertension, label expansions bempedoic acid semaglutide, results major randomised clinical trials (RCTs) that have met...
Resident immune cells are a hallmark of atherosclerotic lesions. The sphingolipid analogue drug FTY720 mediates retrafficking and inhibits their homing to inflammatory sites. We have evaluated the effect on atherogenesis lipid metabolism.ApoE-/- mice normal laboratory diet received oral for 12 weeks, which led 2.4-fold increase in serum cholesterol (largely VLDL fraction) 1.8-fold hepatic HMGCoA reductase mRNA. increased plasma sphingosine-1-phosphate induced marked peripheral blood...
We aimed to identify a novel biomarker involved in the early events leading an acute coronary syndrome (ACS) and evaluate its role diagnosis risk stratification.Biomarker identification was based on gene expression profiling. In thrombi of ACS patients, cysteine-rich angiogenic inducer 61 (Cyr61, CCN1) transcripts were highly up-regulated compared with peripheral mononuclear cells. murine ischaemia-reperfusion model (I/R), myocardial Cyr61 markedly increased controls. levels determined human...
Abstract Aims Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative enhances arterial thrombosis. This study investigated the effects genetic Sirt3 deletion on thrombosis in mice an inflammatory setting and assessed clinical relevance these findings patients with ST-elevation myocardial infarction (STEMI). Methods results Using laser-induced carotid model...