A5084853870- Folate and B Vitamins Research
- Diet and metabolism studies
- Tryptophan and brain disorders
- Nutritional Studies and Diet
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Fatty Acid Research and Health
- Metabolism and Genetic Disorders
- Cardiovascular Disease and Adiposity
- Stress Responses and Cortisol
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Function and Risk Factors
- Metabolomics and Mass Spectrometry Studies
- GDF15 and Related Biomarkers
- Eicosanoids and Hypertension Pharmacology
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin C and Antioxidants Research
- Bipolar Disorder and Treatment
- Gut microbiota and health
- Vitamin D Research Studies
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
University of Bergen
2014-2025
Haukeland University Hospital
2016-2025
RELX Group (United States)
2024
Institute of Social and Preventive Medicine
2021
University of Bern
2021
University of South Australia
2014-2020
Bevital (Norway)
2010-2016
Norwegian Institute of Public Health
2012-2016
Stavanger University Hospital
2010-2014
Maastricht University
2014
The aim was to study the prognostic value of plasma ceramides (Cer) as cardiovascular death (CV death) markers in three independent coronary artery disease (CAD) cohorts.Corogene is a prospective Finnish cohort including stable CAD patients (n = 160). Multiple lipid biomarkers and C-reactive protein were measured addition Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0), Cer(d18:1/24:1). Subsequently, association between high-risk CV mortality investigated Special Program University...
<h3>Context</h3>Observational studies have reported associations between circulating total homocysteine concentration and risk of cardiovascular disease. Oral administration folic acid vitamin B<sub>12</sub> can lower plasma levels.<h3>Objective</h3>To assess the effect treatment with B<sub>6</sub> as secondary prevention in patients coronary artery disease or aortic valve stenosis.<h3>Design, Setting, Participants</h3>Randomized, double-blind controlled trial conducted 2 university...
Objective— Enhanced tryptophan degradation, induced by the proinflammatory cytokine interferon-γ, has been related to cardiovascular disease progression and insulin resistance. We assessed downstream metabolites of kynurenine pathway as predictors acute myocardial infarction in patients with suspected stable angina pectoris. Furthermore, we evaluated potential effect modifications according diagnoses pre-diabetes mellitus or diabetes mellitus. Approach Results— Blood samples were obtained...
Interferon γ (IFN-γ) is centrally involved in atherosclerosis-related inflammation, but its activity cannot be reliably assessed by systemic measurements. In activated macrophages, IFN-γ stimulates production of neopterin and conversion tryptophan to kynurenine. We evaluated the relationships plasma kynurenine:tryptophan ratio (KTR) long-term prognosis patients with stable angina pectoris angiographically verified significant coronary artery disease.Samples were obtained from 2380 a mean age...
Dimethylglycine is linked to lipid metabolism, and increased plasma levels may be associated with adverse prognosis in patients coronary artery disease. We evaluated the relationship between dimethylglycine risk of incident acute myocardial infarction a large prospective cohort stable angina pectoris, whom approximately two thirds were participants B-vitamin intervention trial. Model discrimination reclassification when adding established factors obtained. also explored temporal changes...
Several compounds in the choline oxidation pathway are associated with insulin resistance and prevalent diabetes; however, prospective data scarce.We explored relationships between systemic urinary choline-related metabolites incident type 2 diabetes an observational study among Norwegian patients.We risk associations by logistic regression 3621 nondiabetic individuals suspected stable angina pectoris, of whom 3242 provided urine samples. Reclassification patients was investigated according...
Excess levels of serum acylcarnitines, which are intermediate products in metabolism, have been observed metabolic diseases such as type 2 diabetes mellitus. However, it is not known whether acylcarnitines may prospectively predict risk cardiovascular death or acute myocardial infarction patients with stable angina pectoris.This study included 4164 (median age, 62 years; 72% men). Baseline acetyl-, octanoyl-, palmitoyl-, propionyl-, and (iso)valerylcarnitine were measured using liquid...
Kynurenine is a potent endothelium-derived vasodilator. Its synthesis from tryptophan stimulated by interferon γ and may represent an important compensatory pathway for the regulation of vascular function in inflammatory conditions. We assessed associations urine kynurenine to ratio (KTR) levels incident major coronary events (MCEs), acute myocardial infarction (AMI), ischaemic stroke mortality patients with suspected stable artery disease (CAD). A total 3224 (mean age 62 years, 69% men)...
The tryptophan metabolite kynurenine has potent immune modulatory and vasoactive properties. Experimental data implicate in obesity-related morbidities. Epidemiological studies are, however, sparse. We evaluated associations of the plasma urine kynurenine:tryptophan ratio (KTR) to incident type 2 diabetes. followed 2519 individuals with coronary artery disease (CAD; 73.1% men) without diabetes at baseline for a median 7.6 years, during which 173 (6.9%) new incidences were identified....
Summary Effective strategies are needed to help individuals lose weight and maintain loss. The primary aim of this study was investigate the effect intermittent energy restriction ( IER ) compared continuous CER on loss after 8 weeks maintenance 12 months. Secondary aims were determine changes in waist hip measurements diet quality. In a randomized parallel study, overweight obese (body mass index [ BMI ] ≥ 27 kg m −2 women stratified by age before randomization. Participants undertook an...
Background Metabolites of the kynurenine pathway (mKP) relate to important aspects heart failure pathophysiology, such as inflammation, energy-homeostasis, apoptosis, and oxidative stress. We aimed investigate whether mKP predict mortality in patients with failure. Methods The study included 202 (73.8% coronary artery disease (CAD)), propensity score matched 384 controls without disease, 807 CAD (71%). All underwent angiography ventriculography at baseline. Plasma mKP, pyridoxal 5'phosphate...