A5031262573- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Hormonal Regulation and Hypertension
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Neuropeptides and Animal Physiology
- European and International Contract Law
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Peptidase Inhibition and Analysis
- Receptor Mechanisms and Signaling
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Potassium and Related Disorders
- Cardiovascular Disease and Adiposity
- GDF15 and Related Biomarkers
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Legal principles and applications
- Conflict of Laws and Jurisdiction
- Circular RNAs in diseases
University of Otago
2016-2025
Christchurch Hospital
2011-2025
National University Health System
2016-2025
National University of Singapore
2016-2025
National University Heart Centre Singapore
2016-2025
New Zealand Brain Research Institute
2015-2025
Christ University
1996-2025
Science for Life Laboratory
2025
University Health System
2017-2025
Uppsala University
2017-2025
Aims Experience with amino-terminal pro-brain natriuretic peptide (NT-proBNP) testing for evaluation of dyspnoeic patients suspected acute heart failure (HF) is limited to single-centre studies. We wished establish broader standards NT-proBNP in a study involving four sites three continents.
Background —Newly discovered circulating peptides, N-terminal pro–brain natriuretic peptide (N-BNP) and adrenomedullin (ADM), were examined for prediction of cardiac function prognosis compared with previously reported markers in 121 patients myocardial infarction. Methods Results —The association between radionuclide left ventricular ejection fraction (LVEF) N-BNP at 2 to 4 days ( r =−.63, P <.0001) 3 5 months =−.58, after infarction was comparable that C-terminal BNP far stronger than...
OBJECTIVE Human brain natriuretic peptide‐32 (BNP) (i.e. proBNP(77–108)), the mature form of BNP and secreted predominantly by cardiac ventricle, is formed from a high molecular weight precursor, proBNP(1–108). We have recently identified aminoterminal proBNP(1–76) (NT‐proBNP) in human plasma but its source, metabolism production circulatory disorders are unknown. investigated relationship between immunoreactive (IR) NT‐proBNP BNP‐32 normal hypertensive subjects patients with impairment, as...
Background— A recent landmark report has demonstrated that plasma B-type natriuretic peptide (BNP) measured in acute coronary syndromes independently predicts mortality, heart failure, and new myocardial infarction. After cardiac injury, left ventricular ejection fraction (LVEF) is also of prognostic significance plays a major role determining the therapeutic response. Methods Results— The present first from substantial (n=666) cohort patients with infarction to test utility concurrent...
Human embryonic stem (ES) cell lines that have the ability to self‐renew and differentiate into specific types been established. The molecular mechanisms for self‐renewal differentiation, however, are poorly understood. We determined transcriptome profiles two proprietary human ES (HES3 HES4, Cell International), compared them with murine cells other tissues. mouse appear share a number of expressed gene products although there numerous notable differences, including an inactive leukemia...
Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study physician-directed patient self-management system targeting left atrial pressure.Forty patients with reduced or preserved ventricular ejection fraction and history New York Heart Association class III IV failure acute decompensation were implanted an investigational pressure monitor, readings acquired twice daily....
Biomass has the potential to become an important source of energy for future automotive fuels. Recent biological and chemical improvements conversion biomass-derived carbohydrates have produced high yields liquid 2,5-dimethylfuran (DMF). This discovery made DMF a possible substitute petroleum-based gasoline, because they share very similar physicochemical properties, which are superior those ethanol. In present study, experiments been carried out on single-cylinder gasoline direct-injection...
Circular RNA (circRNA) is a newly validated class of single-stranded RNA, ubiquitously expressed in mammalian tissues and possessing key functions including acting as microRNA sponges transcriptional regulators by binding to RNA-binding proteins. While independent studies confirm the expression circRNA various tissue types, genome-wide heart has yet be described detail.We performed deep RNA-sequencing on ribosomal-depleted isolated from 12 human hearts, 25 mouse hearts across 28-day...
Whether prevalence and mortality of patients with heart failure preserved or mid-range (40–49%) ejection fraction (HFpEF HFmREF) are similar to those reduced (HFrEF), as reported in some epidemiologic studies, remains highly controversial. We determined compared characteristics outcomes for HFpEF, HFmREF, HFrEF a prospective, international, multi-ethnic population. Prospective multi-centre longitudinal study New Zealand (NZ) Singapore. Patients HF were assessed at baseline followed over 2...