A5052987851- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Palliative Care and End-of-Life Issues
- Cardiac electrophysiology and arrhythmias
- IL-33, ST2, and ILC Pathways
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Potassium and Related Disorders
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Erythropoietin and Anemia Treatment
- Atrial Fibrillation Management and Outcomes
- GDF15 and Related Biomarkers
- Cardiac Fibrosis and Remodeling
- Health Systems, Economic Evaluations, Quality of Life
- Iron Metabolism and Disorders
- Chronic Disease Management Strategies
- Nutrition and Health in Aging
- Congenital Heart Disease Studies
- Childhood Cancer Survivors' Quality of Life
- Intensive Care Unit Cognitive Disorders
- Patient Dignity and Privacy
- MicroRNA in disease regulation
- Cardiac Health and Mental Health
Duke-NUS Medical School
2015-2025
Singapore General Hospital
2015-2024
National University Heart Centre Singapore
2013-2024
Singapore Clinical Research Institute
2024
National Heart Centre Singapore
2021-2022
Mackay Memorial Hospital
2022
Khoo Teck Puat Hospital
2022
National University Hospital
2022
Tan Tock Seng Hospital
2022
Changi General Hospital
2022
Whether prevalence and mortality of patients with heart failure preserved or mid-range (40–49%) ejection fraction (HFpEF HFmREF) are similar to those reduced (HFrEF), as reported in some epidemiologic studies, remains highly controversial. We determined compared characteristics outcomes for HFpEF, HFmREF, HFrEF a prospective, international, multi-ethnic population. Prospective multi-centre longitudinal study New Zealand (NZ) Singapore. Patients HF were assessed at baseline followed over 2...
To define plasma concentrations, determinants, and optimal prognostic cut-offs of soluble suppression tumorigenesis-2 (sST2), high-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP) in women men with chronic heart failure (HF).Individual data patients from the Biomarkers In Heart Failure Outpatient Study (BIOS) Consortium sST2, hs-cTnT, NT-proBNP measured were analysed. The primary endpoint was a composite 1 year cardiovascular death HF...
Left atrial (LA) and ventricular (LV) functional impairment often co-exist in patients with heart failure (HF). However, some HF have a disproportionate LA or LV dysfunction. We aimed to characterize predominant myopathy cohort of chronic across the spectrum ejection fraction (LVEF). From nationwide, prospective, multi-center, observational cohort, transthoracic echocardiographic examination was performed on each patient. reservoir strain global longitudinal (LVGLS) were measured using...
Abstract Aims The importance of iron deficiency (ID) in heart failure with preserved ejection fraction (HFpEF) is unknown. In HF reduced (HFrEF), ID reported as an independent predictor mortality although not all published studies agree. Different definitions have been assessed, and the natural history untreated established, which may explain conflicting results. This study aimed to assess relationship between HFpEF, clarify definition correlates best outcomes HFrEF, determine prognostic...
Influenza is a major cause of mortality and morbidity. We aimed to examine the influenza-associated hospitalization rates proportions for cardiovascular disease (CVD) in tropical Singapore. Hospital admissions ischemic heart (IHD), congestive failure (CHF), overall CVD were obtained from national inpatient database period 2010-2014. used, as key indicator influenza virus activity, proportion specimens outpatients with influenza-like illness community that tested positive part surveillance...
Objective Ethnic differences in the prevalence of atrial fibrillation (AF) heart failure (HF) remain unclear. We compared and clinical correlates AF among different ethnicities an Asian-Pacific population with HF. Methods Patients validated HF were prospectively studied across Singapore New Zealand (NZ). Results Among 1746 patients (62% Asian, 26% women, mean age 66 (SD 13) years, ejection fraction (EF) 37 16%), 39% had AF. The was markedly lower Singapore-Asians than NZ-Europeans (24% vs...
Pathophysiological differences between patients with heart failure preserved (HFpEF) and reduced (HFrEF) ejection fraction (EF) remain unclear. Therefore we used a phenomics approach, integrating selected proteomics data patient characteristics cardiac structural functional parameters, to get insight into differential pathophysiological mechanisms identify potential treatment targets.