A5025512221- Bone health and osteoporosis research
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Vitamin D Research Studies
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Bone health and treatments
- Glaucoma and retinal disorders
- Cardiac Health and Mental Health
- Gout, Hyperuricemia, Uric Acid
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Meta-analysis and systematic reviews
- Bone and Joint Diseases
- Infant Nutrition and Health
- Corneal surgery and disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Parathyroid Disorders and Treatments
University of Auckland
2016-2025
Stanford University
2025
New Zealand Association of Counsellors
2023
Health Research Council of New Zealand
2023
University of Otago
2003-2022
Macquarie University
2018
Auckland City Hospital
1994-2016
National Heart Foundation of Australia
2016
Cardiac Society of Australia and New Zealand
2016
George Institute for Global Health
2016
Chronic obstructive pulmonary disease (COPD) is a common comorbid in lung cancer, estimated to affect 40-70% of cancer patients, depending on diagnostic criteria. As smoking exposure found 85-90% those diagnosed with either COPD or coexisting could merely reflect shared exposure. Potential confounding by age, sex and pack-yr history, and/or the possible effects spirometry, may result over-diagnosis prevalence. In present study, prevalence (pre-bronchodilator Global Initiative for Obstructive...
Studies of acromegaly have shown a doubling mortality compared with the general population. With development new modalities treatment, it has become important to identify prognostic factors relating mortality. Between 1964 and 2000, 208 acromegalic patients were followed for mean 13 yr at Auckland Hospital. Treatment was by surgery or radionuclide pituitary implantation, all except 27 received radiation. Over duration study, 72 died age 61 ± 12.8 yr. Those dying significantly older...
The use of calcium supplements slows bone loss in the forearm and has a beneficial effect on axial density women late menopause whose intake is less than 400 mg per day. However, supplement 1000 day postmenopausal with higher intakes not known.
Context: Thiazolidinediones, which are peroxisome proliferator-activated receptor-γ agonists, widely prescribed to patients with disorders characterized by insulin resistance. Preclinical studies suggest that signaling negatively regulates bone formation and density. Human data on the skeletal effects of thiazolidinediones currently available only from observational studies. Objective: The objective study was determine whether rosiglitazone, a thiazolidinedione, inhibits formation. Design:...
Whether prevalence and mortality of patients with heart failure preserved or mid-range (40–49%) ejection fraction (HFpEF HFmREF) are similar to those reduced (HFrEF), as reported in some epidemiologic studies, remains highly controversial. We determined compared characteristics outcomes for HFpEF, HFmREF, HFrEF a prospective, international, multi-ethnic population. Prospective multi-centre longitudinal study New Zealand (NZ) Singapore. Patients HF were assessed at baseline followed over 2...
BackgroundZoledronate prevents fractures in older women when administered every 12 to 18 months, but its effects on bone density and turnover persist beyond 5 years. Whether infrequent zoledronate administration would prevent vertebral early postmenopausal is unknown.MethodsWe conducted a 10-year, prospective, double-blind, randomized, placebo-controlled trial involving (50 60 years of age) with mineral T scores lower than 0 higher −2.5 (scores −1 or typically indicate normal density) at the...
Importance Neonatal protein intake following very preterm birth has long lasting effects on brain development. However, it is uncertain whether these are associated with improved or impaired maturation. Objective To assess the association of neonatal structure at 7 years age. Design, Setting, and Participants This cohort study involved children born before after a change in intensive care unit nutritional protocol that increased National Women’s Hospital Auckland, New Zealand. The completed...
The CAPRICORN trial has shown that carvedilol improved outcome in patients with left ventricular dysfunction after acute myocardial infarction treated ACE inhibitors. aim of this substudy was to determine the effects on remodeling patient group.Patients entering from 13 centers New Zealand, Australia, and Spain were recruited for echocardiographic substudy. In 127 patients, quantitative 2D echocardiography performed according a standard protocol before randomization repeated 1, 3, 6 months...
There is widespread clinical uncertainty about lowering blood pressure in patients with ischaemic cerebrovascular disease. This often manifests as comparatively high thresholds for starting treatment and modest targets reducing pressure. Concern has arisen partly from reports of a J shaped association between recurrent stroke these patients.1 relation may, however, be because severe strokes are associated both fall pressure2 independently relatively risk recurrence, rather than any adverse...
Aims To determine the effect of an integrated heart failure management programme, involving patient and family, primary secondary care, on quality life death or hospital readmissions in patients with chronic failure.
In many parts of the world number pregnancies in women with Type 2 diabetes mellitus (DM) now exceeds that 1 DM, but there are few data published on perinatal mortality DM. This study reports observational DM from a population high background rate this disorder.Over 12-year period (1985-1997) at Diabetes Clinic National Women's Hospital, Auckland, were 434 (256 known and 178 diagnosed gestational (GDM), confirmed to have early post-partum), 160 932 GDM. Perinatal was classified as either...
Abstract Vitamin D insufficiency is common in patients with primary hyperparathyroidism (PHPT) and may be associated more severe progressive disease. Uncertainty exists, however, as to whether repletion of vitamin should undertaken PHPT. Here we report the effects on biochemical outcomes over 1 yr a group 21 mild PHPT [serum calcium <12 mg/dl (3 mmol/liter)] coexistent 25 hydroxyvitamin [25(OH)D] <20 μg/liter (50 nmol/liter)]. In response serum 25(OH)D level greater than 20...
Cholesterol lowering in patients with above-average cholesterol levels has been shown to reduce the progression of atherosclerosis and lower risk coronary heart disease events. However, there uncertainty about effects average or below-average levels.In this study, 522 a history myocardial infarction unstable angina baseline total between 4 7 mmol/L (mean, 5.7 mmol/L) were randomized treatment low fat diet plus pravastatin (40 mg daily) placebo. Treatment reduced by 19%, LDL 27%,...
Context: Intravenous aminobisphosphonates often cause an acute-phase response (APR), but the precise components of this, its frequency, and risk factors for development have not been systematically studied. Objective: The objective study was to characterize APR determine frequency development. Design: analysis adverse events from a large randomized trial. Setting: This multicenter international Patients: Patients included 7765 postmenopausal women with osteoporosis. Intervention: Zoledronic...
To characterize the cellular architecture of tophus and to determine presence cytokines implicated in initiation resolution gouty inflammation.Sixteen fixed, paraffin-embedded, uninfected samples were surgically obtained from 12 patients with microscopically proven gout analyzed by quantitative immunohistochemistry. The number cells present corona fibrovascular zones was Genmod mixed models analysis.Numerous CD68+ mononucleated multinucleated within zone. Mast identified all at similar...