A5090695901- Bone health and treatments
- Bone health and osteoporosis research
- Parathyroid Disorders and Treatments
- Gestational Diabetes Research and Management
- Bone and Joint Diseases
- Vitamin D Research Studies
- Connective tissue disorders research
- Pregnancy and preeclampsia studies
- Bone Tumor Diagnosis and Treatments
- Fibroblast Growth Factor Research
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Bariatric Surgery and Outcomes
- Birth, Development, and Health
- Cancer-related Molecular Pathways
- Diabetes Management and Research
- Pharmacological Effects and Toxicity Studies
- Bone Metabolism and Diseases
- Estrogen and related hormone effects
- Cancer and Skin Lesions
- Alkaline Phosphatase Research Studies
- Diabetes and associated disorders
- Menopause: Health Impacts and Treatments
- Pregnancy-related medical research
- Chronic Kidney Disease and Diabetes
University of Auckland
2016-2025
Auckland City Hospital
1994-2022
Greenlane Clinical Centre
2008-2021
Auckland District Health Board
2016-2021
Institute of the Americas
2018
Far East University
2018
University of Sheffield
1978-2015
Churchill Hospital
1978-2015
University of Liège
1981-2015
Development Fund
2012
OBJECTIVE--To determine if the use of injectable contraceptive depot medroxyprogesterone (DMPA), which reduces ovarian oestrogen production, is associated with changes in bone density. DESIGN--Population study. DMPA users were compared two control groups selected from larger population studies and individually matched for several putative determinants density (age, race, body mass index, years deficiency). Controls without prior knowledge their measurements. SETTING--Teaching hospital...
In many parts of the world number pregnancies in women with Type 2 diabetes mellitus (DM) now exceeds that 1 DM, but there are few data published on perinatal mortality DM. This study reports observational DM from a population high background rate this disorder.Over 12-year period (1985-1997) at Diabetes Clinic National Women's Hospital, Auckland, were 434 (256 known and 178 diagnosed gestational (GDM), confirmed to have early post-partum), 160 932 GDM. Perinatal was classified as either...
To explore the mechanism underlying severe hypomagnesaemia in long-term users of proton-pump inhibitors (PPIs).Two cases adult PPI omeprazole, presenting with hypocalcaemic seizures.We studied renal magnesium handling during an incremental intravenous infusion, and assessed total body status by 24-h retention parenteral load. We also observed effects oral supplements whilst continuing PPI, effect withdrawal PPI.Both patients were severely magnesium-depleted had avid retention, implicating a...
Idiopathic hyperphosphatasia is an autosomal recessive bone disease characterized by deformities of long bones, kyphosis and acetabular protrusion, increasing in severity as affected children pass through adolescence. Biochemical histological evidence indicate that there extremely rapid turnover, with indices both resorption formation greatly increased. A genome-wide search, a family three idiopathic hyperphosphatasia, suggested linkage to locus on the arm chromosome 8 (8q24). The gene...
This article is part of a series on overdiagnosis looking at the risks and harms to patients expanding definitions disease increasing use new diagnostic technologies.Maternal obesity, excess maternal weight gain during pregnancy, gestational diabetes are all associated with large for age infants other adverse outcomes.With obesity being major risk factor (diabetes first recognised in pregnancy), incidence condition unsurprising.Treatment pregnancy has disappointingly little effect numbers...
Although biallelic mutations in non-collagen genes account for <10% of individuals with osteogenesis imperfecta, the characterization these has identified new pathways and potential interventions that could benefit even those type I collagen genes. We FKBP10, which encodes 65 kDa prolyl cis–trans isomerase, FKBP65, 38 members 21 families OI. These include 10 from Samoan Islands who share a founder mutation. Of mutations, three are missense; remainder either introduce premature termination...
To determine the frequency of major congenital anomalies in offspring women with gestational diabetes (GDM), classified according to their postpartum glucose tolerance status.A prospective study pregnancies Type 1 (n = 221), 2 317) and GDM 1822) between 1985 2000 (15 years). Congenital were detected by antenatal ultrasound or postnatal examination.The was 5.9% (95% confidence interval (CI) 3.2-9.8) for diabetes; 4.4% CI 2.4-7.3) 1.4% 0.9-2.0) GDM. Two hundred thirty-seven (13%) had diagnosed...
In order to determine whether the loss in bone density seen users of depot medroxyprogesterone acetate is reversible, a comparative study was undertaken three groups women. Group 1 consisted 14 women who had used contraceptive for at least 3 years and then discontinued use. 2 22 longterm users, contained 18 never drug served as controls. Estrogen production resumed all after discontinuation. Two measurements were taken twice each woman. At first measurement, lumbar spine an average 9% lower...
<b><i>Background:</i></b> Ciguatera poisoning (CP) is worldwide the most common fish-borne illness and one of forms nonbacterial food poisoning. IV mannitol considered treatment choice for CP but has not been evaluated in a double-blind randomized trial. <b><i>Methods:</i></b> A prospective clinical study 50 patients with on Rarotonga, Cook Islands, was conducted to better define neurologic picture effect or normal saline under conditions over 24-hour period. <b><i>Results:</i></b> The...
Paget's disease is characterized by highly localized areas of increased osteoclast (OCL) activity. This suggests that the microenvironment in pagetic lesions osteoclastogenic, or OCL precursors these are hyperresponsive to osteoclastogenic factors (or both). To examine possibilities, we compared RANK ligand (RANKL) mRNA expression a marrow stromal cell line developed from lesion (PSV10) with normal (Saka), and samples affected bones patients marrow. RANKL was PSV10 cells Saka marrow, also...
The effect of successful liver transplantation on menstrual function was assessed by questionnaire in 44 women transplanted for various types end stage disease, acute failure or malignant disease. Significant amenorrhoea (greater than one year) present 48% with chronic disease before transplantation, and reversed within 10 months surgery all but the premenopausal patients who had primary hypogonadotrophic hypogonadism. Two became pregnant five 1.5 years after instance pregnancy unsuccessful,...
Abstract Three novel missense mutations of SQSTM1 were identified in familial PDB, all affecting the UBA domain. Functional and structural analysis showed that disease severity was related to type mutation but unrelated polyubiquitin-binding properties mutant domain peptides. Introduction: Mutations ubiquitin-associated (UBA) Sequestosome 1 (SQSTM1) gene have recently been as a common cause Paget's bone (PDB), mechanisms responsible are unclear. We three conducted functional analyses...
The rising prevalence of obesity in childhood and adolescence North America has been paralleled by the emergence type 2 diabetes adolescent age group. We have examined trends adolescents attending a clinic Auckland, New Zealand.Surveys attendees at Auckland Diabetes Centre were undertaken 1996 2002. proportion incident cases diagnosed between these years was also calculated.The 1.8% (2/110) 1996, 11.0% (18/163) 2002 (P = 0.008). Type accounted for 12.5% (6/48) 1997-1999, 35.7% (10/28)...
Abstract This study assessed differences between Europeans, South Asians and Pacific Islanders in illness perceptions, self-efficacy, self-care, metabolic control retinopathy diabetes. We also evaluated the role of perceptions self-efficacy diabetes self-care within each group. A total 86 Asians, 87 with type-2 completed self-report measures self-care. Metabolic data were collected from patient records. Results showed that held shorter timeline compared to Europeans. Relative both other...
Radiographs of the hands and feet 19 diabetic patients with severe neuropathy were compared to those 22 control without neuropathy. The two groups matched for age, sex, duration diabetes. Cortical bone mass, measured by x-ray morphometry, was significantly lower in both (p less than 0.002) 0.001) osteopenia worse also women. Serum alkaline phosphatase levels higher group 0.005). Metatarsal fractures a frequent finding neuropathic patients, but not seen controls. presence metatarsal strongly...
Small doses (1-10 microgram daily) of 24,25-dihydroxycholecalciferol (24,25-(OH)2D3), a renal metabolite vitamin D uncertain function, increased intestinal absorption calcium in normal people and patients with various disorders or mineral metabolism, including anephric subjects. In five six studied, balance increased, but, unlike 1,25-dihydroxycholecalciferol, 24,25-(OH)2D3 did not increase plasma urinary concentrations. These results suggest that may be an important regulator skeletal...
Objective Generic medications are associated with reduced perceived effectiveness, increased adverse effects, and rates of nonadherence compared brand-name medications. This study examined the effect an apparent medication formulation change on subjective objective measures effectiveness side effects. Methods Sixty-two university students participated in a purportedly testing fast-acting β-blocker reducing preexamination anxiety. All tablets were placebos. In session 1, all participants...