William Ying Khee Hwang
A5008909013- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Polyomavirus and related diseases
- Multiple Myeloma Research and Treatments
- Immunotherapy and Immune Responses
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- COVID-19 and healthcare impacts
- Viral-associated cancers and disorders
- Virus-based gene therapy research
- Neonatal Respiratory Health Research
- Immune cells in cancer
- T-cell and Retrovirus Studies
- Transplantation: Methods and Outcomes
- Economic and Financial Impacts of Cancer
- Hematological disorders and diagnostics
- Renal Transplantation Outcomes and Treatments
Singapore General Hospital
2016-2025
National Cancer Centre Singapore
2016-2025
SingHealth
2004-2025
Duke-NUS Medical School
2015-2024
National University of Singapore
2008-2024
KK Women's and Children's Hospital
2023
San Salvatore Hospital
2021
Università Campus Bio-Medico
2021
SingHealth Duke-NUS Academic Medical Centre
2008-2021
European Society for Blood and Marrow Transplantation
2016
Significance Mucosa-associated invariant T (MAIT) cells are unconventional innate-like recognizing microbial riboflavin metabolites presented by the monomorphic MR1 molecule. Here, we show that CD8 + CD4 − and subpopulations of human MAIT represent transcriptionally phenotypically discrete subsets with distinct functional profiles. Furthermore, cell receptor repertoire analysis, as well data based on fetal tissues, umbilical cord blood, culture systems indicate subset may derive from main...
The coronavirus disease 2019 (COVID-19) pandemic has had a global impact, and Singapore seen 33,000 confirmed cases. Patients with cancer, their caregivers, health care workers (HCWs) need to balance the challenges associated COVID-19 while ensuring that cancer is not compromised. This study aimed evaluate psychological effect of on these groups prevalence burnout among HCWs.
Purpose Increasing the number of hematopoietic stem and progenitor cells within an umbilical cord blood (UCB) graft shortens time to recovery after UCB transplantation. In this study, we assessed safety efficacy a that was expanded ex vivo in presence nicotinamide transplanted myeloablative conditioning as stand-alone stem-cell graft. Methods Thirty-six patients with hematologic malignancies underwent transplantation at 11 sites. Results The cumulative incidence neutrophil engraftment day 42...
Background & AimsHepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV-DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated epitopes are recognized by T cells and their presence in can be used to select HBV-specific T-cell receptors (TCRs) for immunotherapy.MethodsHCC negative antigens, based on immunohistochemistry, were analyzed the messenger RNAs (mRNAs) real-time...
Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes. The progressive shortening steady-state telomere length in normal human somatic cells is a promising biomarker for age-associated diseases. However, there remain substantial challenges quantifying due to lack high-throughput method with nucleotide resolution individual telomere. Here, we describe workflow capture telomeres using newly designed telobaits culture cell lines as well clinical patient samples...
Keratoconjunctivitis sicca (KCS) occurs in 40%-60% of patients with chronic graft-versus-host-disease (cGVHD) after allogeneic hematopoietic cell transplantation. Although immunosuppressive therapy is the primary treatment GVHD, ocular symptoms require measures to improve lubrication, decrease inflammation, and maintain mucosal integrity. The liquid corneal bandage provided by a fluid-ventilated, gas-permeable scleral lens (SL) has been effective mitigating resurfacing erosions KCS related...
The study of myelodysplastic syndromes (MDS) in murine models has now indicated the possible involvement bone marrow microenvironment generation dysplastic hematopoietic cells. However, there is scant work on patient samples and role hypomethylating agents stromal cells MDS patients unclear. We show that human MDS-MSCs exhibit phenotypic, transcriptomic epigenetic abnormalities. Stimuli provided by impaired growth function healthy HSPCs, which further sustained autonomously HSPCs for...