A5059682589- Surface Modification and Superhydrophobicity
- Microfluidic and Capillary Electrophoresis Applications
- Biosensors and Analytical Detection
- Nanomaterials and Printing Technologies
- Heart Failure Treatment and Management
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrohydrodynamics and Fluid Dynamics
- Microfluidic and Bio-sensing Technologies
- Pickering emulsions and particle stabilization
- Fluid Dynamics and Heat Transfer
- Electrowetting and Microfluidic Technologies
- GDF15 and Related Biomarkers
- Leaf Properties and Growth Measurement
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- Transgenic Plants and Applications
- Nutrition and Health in Aging
- Viral Infectious Diseases and Gene Expression in Insects
- Micro and Nano Robotics
- Advanced Fluorescence Microscopy Techniques
- Genetics, Bioinformatics, and Biomedical Research
- Cell Image Analysis Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
National University Health System
2015-2025
National University of Singapore
2016-2025
National University Heart Centre Singapore
2015-2025
Singapore Clinical Research Institute
2017-2024
National Heart Centre Singapore
2023
Monash University
2019-2022
Yong In University
2014-2021
University Health System
2014-2021
Center for Translational Molecular Medicine
2014-2021
Cardiovascular Institute Hospital
2011-2021
Growing interest in lanthanide-doped nanoparticles for biological and medical uses has brought particular attention to their safety concerns. However, the intrinsic toxicity of this new class optical nanomaterials systems not been fully evaluated. In work, we systematically evaluate long-term cytotoxicity (NaGdF4 NaYF4) HeLa cells by monitoring cell viability (mitochondrial activity), adenosine triphosphate (ATP) level, membrane integrity (lactate dehydrogenase release), respectively....
By virtual screening, compound 1 was found to be active against NS2B-NS3 protease (IC(50) = 13.12 ± 1.03 μM). Fourteen derivatives (22) of were synthesized, leading the discovery four new inhibitors with biological activity. In order expand chemical diversity inhibitors, small-molecule-based scaffold hopping performed on basis common compounds and 22. Twenty-one (23, 24) containing quinoline (new scaffold) designed synthesized. Protease inhibition assays revealed that 12 are protease. Taken...
The handling of chemicals in the laboratory presents a challenge instructing large class sizes and when students are relatively new to environment. In this work, we describe demonstrate an augmented reality colorimetric titration tool that operates out smartphone or tablet students. It allows multiple conduct exercise at same time, respond quickly actions made, correctly depict colors associated with changes pH values for indicator used. imbues unparalleled realism experiment offers strongly...
Vascular pathology plays an important role in the development of cognitive decline and dementia. In this context, growth differentiation factor-15 (GDF-15) has been suggested to be a biomarker due its regulatory roles inflammatory trophic responses during tissue injury. However, limited data exist on associations GDF-15 with either cerebrovascular disease (CeVD) burden or spectrum impairment. Therefore, we aimed study peripheral levels incognitive impairment no dementia (CIND) Alzheimer (AD)...
Abstract INTRODUCTION The prognostic utility of plasma proteomics for cognitive decline and dementia in a Southeast Asian population characterized by high cerebrovascular disease (CeVD) burden is underexplored. METHODS We examined this Singaporean memory clinic cohort 528 subjects ( n = 300, CeVD; 167, incident decline) followed‐up 4 years. RESULTS Of 1441 proteins surveyed, 12‐protein signature significantly predicted q ‐value < .05). Sixteen diverse biological processes were implicated...
The large number of mutations identified across all cancers represents an untapped reservoir targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available. We report here our attempt to generate such reagents: monoclonal antibodies against the most common R175H, R248Q, and R273H hotspot mutants tumor suppressor p53. These recognize their intended specific alterations without any cross-reactivity wild-type (WT) p53 or other mutants,...
Abstract Background Heart failure (HF) and diabetes are associated with increased incidence worse prognosis of each other. The prognostic value global longitudinal strain (GLS) measured by cardiovascular magnetic resonance (CMR) has not been established in HF patients diabetes. Methods In this prospective, observational study, consecutive ( n = 315) underwent CMR at 3T, including GLS, late gadolinium enhancement (LGE), native T1, extracellular volume fraction (ECV) mapping. Plasma biomarker...
The relationship of serial NT-proBNP (N-terminal pro-B-type natriuretic peptide) measurements with changes in cardiac features and outcomes heart failure (HF) remains incompletely understood. We determined whether common clinical covariates impact these relationships.
ABSTRACT The NS2B cofactor is critical for proteolytic activation of the flavivirus NS3 protease. To elucidate mechanism involved in NS2B-mediated protease, molecular dynamic simulation, principal component analysis, docking, mutagenesis, and bioassay studies were carried out on both dengue virus NS3pro NS2B-NS3pro systems. results revealed that complex more rigid than alone due to its robust hydrogen bond hydrophobic interaction networks within complex. These potent lead remodeling...