A5066428139- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Advanced X-ray and CT Imaging
- Acute Myocardial Infarction Research
- Sex and Gender in Healthcare
- Radiation Dose and Imaging
- Vascular Procedures and Complications
- Diversity and Career in Medicine
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Coronary Artery Anomalies
- Antiplatelet Therapy and Cardiovascular Diseases
- Medical and Biological Sciences
- Health Systems, Economic Evaluations, Quality of Life
- Health and Medical Research Impacts
- Advanced MRI Techniques and Applications
- Single-cell and spatial transcriptomics
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Potassium and Related Disorders
Imperial College Healthcare NHS Trust
2023-2024
IRCCS Humanitas Research Hospital
2022-2023
Humanitas University
2022-2023
Hammersmith Hospital
2023
Utrecht University
2018-2021
University Medical Center Utrecht
2015-2021
Heidelberg University
2018-2021
University Hospital Heidelberg
2018-2021
University Hospitals of Derby and Burton NHS Foundation Trust
2021
Background Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount data from murine atherosclerosis models, evidence B‐cell involvement in human atherosclerotic disease limited. We therefore investigated association circulating subtypes with occurrence secondary cardiovascular events advanced disease. Methods Results This cohort study consists 168 patients who were included Athero‐Express biobank between 2009 2011....
Abstract Aims This study aimed to assess the sex‐specific distribution of heart failure (HF) with preserved, mid‐range, and reduced ejection fraction across three health care settings. Methods results In this descriptive observational study, we retrieved HF types [with (HFrEF), mid‐range (HFmrEF), preserved (HFpEF)] for men women between 65 79 years age in settings from a single country: (i) patients screening‐detected high‐risk community (i.e. those shortness breath, frailty, diabetes...
Elevated serum levels of growth differentiation factor-15 (GDF-15), is an established risk factor for a range cardiovascular diseases. We aimed to evaluate the predictive value plasma GDF-15 as biomarker secondary events (CVE) in patients with atherosclerosis undergoing carotid endarterectomy (CEA). Secondly, we determined whether was associated plaque characteristics.Circulating were by Luminex assay cohort 1056 from Athero-Express biobank. Composite endpoint defined major CVE, death and...
Background Prevalence of undetected heart failure in older individuals is high the community, with patients being at increased risk morbidity and mortality due to chronic progressive nature this complex syndrome. An essential, yet currently unavailable, strategy pre-select candidates eligible for echocardiography confirm or exclude would identify earlier, enable targeted interventions prevent disease progression. The aim study was therefore develop validate such a model that can be...
Although endothelial cell adhesion molecules (CAMs) are postulated to play a key role in early atherosclerosis, studies on CAMs mainly pertained middle-aged populations and with an unfavourable cardiovascular risk burden. Therefore, this study evaluated whether circulating related magnetic resonance imaging (CMR) derived indicators of arterial wall alterations random sample young adults from the general population. This cross-sectional is part general-population-based...
Abstract Background The prevalence of undetected left ventricular diastolic dysfunction is high, especially in the elderly with comorbidities. Left a prognostic indicator heart failure, particularly failure preserved ejection fraction and future cardiovascular all-cause mortality. Therefore we aimed to develop sex-specific diagnostic models enable early identification men women at high-risk or without symptoms who require more aggressive preventative strategies. Design Individual patient...
Introduction Left ventricular diastolic dysfunction (LVDD) is a common condition in both sexes that may deteriorate into heart failure (HF) with preserved ejection fraction (pEF), although this seems to happen more often women than men. Both LVDD and HFpEF go unrecognised, necessitating the discovery of biomarkers aid identification individuals at risk developing HF most likely benefit from treatment. Methods analysis HELPFul an ongoing case-cohort study Dutch cardiology outpatient clinic...
OPINION article Front. Med., 17 October 2018 | https://doi.org/10.3389/fmed.2018.00294
Percutaneous treatment for ostial left circumflex artery (LCx) lesions is known to be associated with suboptimal results.The present study aims assess the procedural and long-term clinical outcomes of percutaneous coronary intervention (PCI) de novo LCx overall according revascularization strategy.Consecutive patients undergoing PCI second generation drug eluting stents or coated balloons in three high-volume Italian centers between 2012 2021 were retrospectively evaluated. The primary...
Despite the recent movements for female equality and empowerment, few women occupy top positions in scientific decision-making. The challenges face during their career may arise from societal biases current culture. We discuss effect of such at three different levels provide suggestions to tackle them. At level, gender roles can create a negative feedback loop which are discouraged attaining men choosing home-centred lifestyle. This be broken early life by providing children with role models...
Chronic total occlusion (CTO) revascularization is a major source of radiation for both patients and physicians. Therefore, efforts to minimize during CTO percutaneous coronary intervention (PCI) are highly encouraged.To evaluate the impact an Ultra Low fluoroscopic Dose Protocol (ULDP), based on 3.75 frames per second fluoroscopy 7.5 cine acquisition, PCI.One hundred fifty consecutive who underwent PCI were retrospectively enrolled. Eighty-five standard dose protocol (SDP) 65 ULDP....