A5088162764- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Vascular Procedures and Complications
- Cardiac Valve Diseases and Treatments
- Educational Games and Gamification
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Stroke Rehabilitation and Recovery
- Peripheral Artery Disease Management
- Air Quality and Health Impacts
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- Digital Games and Media
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Rate Variability and Autonomic Control
- Heart rate and cardiovascular health
- Health Systems, Economic Evaluations, Quality of Life
- Climate Change and Health Impacts
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Air Quality Monitoring and Forecasting
- Cardiac Structural Anomalies and Repair
Worcestershire Royal Hospital
2013-2025
Worcestershire Acute Hospitals NHS Trust
2019-2024
University of Birmingham
2002-2012
Institut Cardiovasculaire Paris Sud
2007-2011
Queen Elizabeth University Hospital
2010
NIHR Surgical Reconstruction and Microbiology Research Centre
2005-2010
Hanson Institute
2009
South Australia Pathology
2009
Institute of Social and Preventive Medicine
2009
Clinique du Sport
2009
Percutaneous coronary intervention (PCI) is frequently performed to reduce the symptoms of stable angina. Whether PCI relieves angina more than a placebo procedure in patients who are not receiving antianginal medication remains unknown. We conducted double-blind, randomized, placebo-controlled trial with Patients stopped all medications and underwent 2-week symptom assessment phase before randomization. were then randomly assigned 1:1 ratio undergo or followed for 12 weeks. The primary end...
Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed determine whether improves major outcomes in ischaemic heart disease.ALL-HEART was multicentre, prospective, randomised, open-label, blinded-endpoint trial done 18 regional centres England and Scotland, recruited from 424 primary care practices. Eligible were aged 60 years or older, disease...
To assess the effects of 1- or ≥3-month dual antiplatelet therapy (DAPT) in high bleeding risk (HBR) patients who received biodegradable-polymer sirolimus-eluting stents for complex percutaneous coronary intervention (PCI) and/or acute syndrome (ACS).In MASTER DAPT trial, 3383 underwent non-complex (abbreviated DAPT, n = 1707; standard 1676) and 1196 588; 608) PCI. Co-primary outcomes at 335 days were net adverse clinical events [NACE; composite all-cause death, myocardial infarction,...
To measure the inflammatory and autonomic responses of healthy humans patients with coronary artery disease to controlled concentrations two specific components vehicle derived air pollution, carbon particles sulphur dioxide (SO2).Placebo controlled, double blind, random order human challenge study examining effects (50 microg/m3) SO2 (200 parts per billion (ppb)) on heart rate variability (HRV) circulating markers inflammation coagulation in volunteers stable angina.In volunteers, cardiac...
Importance Abbreviated dual antiplatelet therapy (DAPT) reduces bleeding with no increase in ischemic events patients at high risk (HBR) undergoing percutaneous coronary intervention (PCI). Objectives To evaluate the association of sex comparative effectiveness abbreviated vs standard DAPT HBR. Design, Setting, and Patients This prespecified subgroup analysis followed Management High Bleeding Risk Post Bioresorbable Polymer Coated Stent Implantation With an Standard Regimen (MASTER DAPT)...
Abstract Introduction This study investigates the relation between changes in pulse oximeter oxygen saturation (Sp O 2 ) and arterial (Sa critically ill, effects of acidosis anaemia on precision using oximetry to predict Sa . Patients methods Forty-one consecutive patients were recruited from a nine-bed general intensive care unit into 2-month study. with significant jaundice (bilirubin >40 μmol/l) or inadequate tracing excluded. Results A total 1085 paired readings demonstrated only...
Cardiac surgery is the reference treatment for patients with left main (LM) disease, although percutaneous coronary intervention drug-eluting stents emerging as a possible alternative. The objective of this registry was to evaluate 2-year outcome elective unprotected LM disease paclitaxel-eluting stents.A total 291 were prospectively included from 4 centers. Acute myocardial infarction and cardiogenic shock only exclusion criteria. Patients 69+/-11 years old, 29% diabetic, 25% had 3-vessel...
Abstract While the field of leadership studies includes a large corpus literature and studies, scientific research in e‐leadership soft skills used learning game environments are at present small scale. Towards contributing to this newly emerging study, paper presents new model, e‐Leadership Soft Skills Educational Design Model ( ELESS ) for assessing use constructing effective design multiplayer environments. The central question considers: what is role how can it be designed tested context...
In healthy young subjects there is direct evidence for sympathetic vasoconstrictor activation after drinking water, but this not accompanied by an increase in arterial blood pressure. A marked pressor response to water ingestion has, however, been observed elderly and patients with autonomic failure. We examined the effect of on haemodynamic variables heart rate variability (HRV) markers cardiac vagal control ten four transplant recipients confirmed persistent denervation. a random order...
The synthesis and the 5-HT receptor activity of a novel series N,N-dimethyltryptamines substituted in 5-position with an imidazole, triazole, or tetrazole ring are described. objective this work was to identify potent selective 5-HT1D agonists high oral bioavailability low central nervous system penetration. Compounds have been prepared which azole is attached through either nitrogen carbon indole. Conjugated methylene-bridged derivatives studied (n = 0 1). Substitution has explored alpha...
Undilatable coronary lesions, due to calcification, are encountered with increasing frequency. Percutaneous intervention of such lesions comes the risk stent underexpansion, which increases thrombosis and restenosis. A variety techniques devices available assist interventionist in treatment calcified lesions. The OPN NC (SIS-Medical AG, Winterthur, Switzerland) is a high-pressure balloon (rated burst pressure 35 atm) that uses novel, twin-layer technology ensure uniform expansion,...
Background Coronary bifurcation lesions (CBLs) are frequently encountered in clinical practice and associated with worse outcomes after percutaneous coronary intervention. However, there limited data around the prognostic impact of different CBL distributions. Methods Results All intervention procedures from prospective e‐Ultimaster (Prospective, Single‐Arm, Multi Centre Observations Ultimaster Des Registry) multicenter international registry were analyzed according to distribution as...
Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most countries, number physicians and centres with expertise EVT limited. Thus, only a small proportion eligible patients receive this potentially life-saving therapy, often after significant delays. Hence, there an unmet need train sufficient stroke intervention order...