A5065253955- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Sex and Gender in Healthcare
- Estrogen and related hormone effects
- Retinal Imaging and Analysis
- Vascular anomalies and interventions
- Radiopharmaceutical Chemistry and Applications
- Clinical practice guidelines implementation
- Vascular Procedures and Complications
- Medical Education and Admissions
- Diabetes Treatment and Management
- Artificial Intelligence in Healthcare and Education
- AI in cancer detection
- Cell Adhesion Molecules Research
- Pharmaceutical Economics and Policy
- Health Systems, Economic Evaluations, Quality of Life
Ente Ospedaliero Cantonale
2023-2024
Università della Svizzera italiana
2023-2024
University Hospital of Bern
2019-2023
University of Bern
2019-2023
Fujita Health University
2023
Maria Cecilia Hospital
2010
San Raffaele University of Rome
2007
Importance Abbreviated dual antiplatelet therapy (DAPT) reduces bleeding with no increase in ischemic events patients at high risk (HBR) undergoing percutaneous coronary intervention (PCI). Objectives To evaluate the association of sex comparative effectiveness abbreviated vs standard DAPT HBR. Design, Setting, and Patients This prespecified subgroup analysis followed Management High Bleeding Risk Post Bioresorbable Polymer Coated Stent Implantation With an Standard Regimen (MASTER DAPT)...
The optimal duration of antiplatelet therapy (APT) after coronary stenting in patients at high bleeding risk (HBR) presenting with an acute syndrome remains unclear. objective this study was to investigate the safety and efficacy abbreviated APT regimen HBR population or recent myocardial infarction. In MASTER DAPT trial, 4,579 were randomized 1 month dual (DAPT) (DAPT stopped 11 months single 5 oral anticoagulants) nonabbreviated for minimum 3 months) strategies. Randomization stratified by...
Disseminated tumor cells (DTCs) contribute to metastasis formation by adapting the hostile environmental conditions encountered at seeded secondary organs. This phenotypic plasticity is supported epigenetic reprogramming of cis-regulatory elements (CREs), representing a hallmark metastatic cells. DTCs can enter reversible state cancer dormancy, resulting from their ability quiescence after mitosis and escape immune surveillance. In this respect, may represent window opportunity increase...
Background: patients with long-lasting permanent atrial fibrillation (AF) are often destined to remain in AF life-long. In this cohort outcomes of ablation techniques disappointing, 20 –74% success rate and 30 –50% repeat procedure. The adjunctive clinical benefit targeting multiple right left (LA) sites beyond the pulmonary vein (PV)-LA junction aim achieving acute termination has not been prospectively evaluated a randomized study. Methods results: 60 more than 1 year duration, early...
Background: Whether there are treatment tradeoffs between bivalirudin and heparin in patients with NSTEMI undergoing PCI is controversial. Study-level meta-analyses lack granularity to provide conclusive answers or assess subgroups. Methods: We performed an individual-patient-data pooled analysis from all 5 large (n >1000) RCTs of vs (MATRIX, VALIDATE-SWEDEHEART, ISAR-REACT 4, ACUITY, BRIGHT). The primary efficacy outcome was the 30-day rate all-cause mortality. Other prespecified...
Background: Given differences in prior trial designs, the treatment tradeoffs between bivalirudin and heparin patients with STEMI undergoing PCI remain uncertain. Study-level meta-analyses lack granularity to provide conclusive answers or assess subgroups. Methods: We performed an individual-patient-data pooled analysis from all 6 large (n>1000) RCTs of vs pts (BRIGHT, EUROMAX, HEAT-PPCI, HORIZONS-AMI, MATRIX, VALIDATE-SWEDEHEART). The primary efficacy outcome was 30-day rate all-cause...