Paolo Calabrò
A5000200390- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Arrhythmias and Treatments
- Vascular Procedures and Complications
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Cancer, Lipids, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Pharmaceutical Economics and Policy
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
University of Campania "Luigi Vanvitelli"
2016-2025
Ospedale Sant'Anna
2018-2025
Ospedale Monaldi
2011-2025
I.R.C.C.S. Oasi Maria SS
2018-2024
University of Naples Federico II
2010-2024
Sorbonne Université
2024
Assistance Publique – Hôpitaux de Paris
2024
Ospedale Maggiore
2015-2024
Magna Graecia University
2024
University of Catania
2024
Abstract Aims To evaluate the impact of COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results We conducted a multicentre, observational, nationwide survey collect data for acute myocardial infarction (AMI) at CCUs throughout 1 week period during outbreak, compared with equivalent in 2019. observed 48.4% reduction AMI 2019 (P < 0.001). The was significant both ST-segment elevation [STEMI; 26.5%, 95% confidence interval (CI) 21.7–32.3; P =...
Background— Serum C-reactive protein (CRP) levels are good predictors of the development cardiovascular events in apparently healthy men and women. CRP has been believed to be produced exclusively by hepatocytes during acute-phase response. Several lines evidence have suggested that atherosclerotic arteries can also produce CRP. However, cell types locally arterial wall not clearly identified. Methods Results— Human coronary artery smooth muscle cells (HCASMCs) human umbilical vein...
Conflicting evidence exists on the efficacy and safety of bivalirudin administered as part percutaneous coronary intervention (PCI) in patients with an acute syndrome.We randomly assigned 7213 syndrome for whom PCI was anticipated to receive either or unfractionated heparin. Patients group were subsequently not a post-PCI infusion. Primary outcomes comparison between heparin occurrence major adverse cardiovascular events (a composite death, myocardial infarction, stroke) net clinical...
Abstract Background The inflammatory response occurring in acute myocardial infarction (AMI) has been proposed as a potential pharmacological target. Sodium-glucose co-transporter 2 inhibitors (SGLT2-I) currently receive intense clinical interest patients with and without diabetes mellitus (DM) for their pleiotropic beneficial effects. We tested the hypothesis that SGLT2-I have anti-inflammatory effects along glucose-lowering properties. Therefore, we investigated link between stress...
To investigate in-hospital and long-term prognosis in T2DM patients presenting with acute myocardial infarction (AMI) treated SGLT2-I versus other oral anti-diabetic agents (non-SGLT2-I users).
Abstract Background Sodium–glucose transporter 2 inhibitors (SGLT2-I) could modulate atherosclerotic plaque progression, via down-regulation of inflammatory burden, and lead to reduction major adverse cardiovascular events (MACEs) in type diabetes mellitus (T2DM) patients with ischemic heart disease (IHD). T2DM multivessel non-obstructive coronary stenosis (Mv-NOCS) have over-inflammation over-lipids’ accumulation. This reduce fibrous cap thickness (FCT), favoring rupture MACEs. Despite...
No study evaluated the incidence of intra-stent restenosis (ISR)-related events in patients with type 2 diabetes (T2DM) and acute myocardial infarction (AMI) treated or not sodium/glucose cotransporter inhibitors (SGLT2i).We recruited 377 T2DM AMI undergoing percutaneous coronary intervention (PCI). Among them, 177 were SGLT2 before PCI. The primary outcome was major adverse cardiovascular (MACE) defined as cardiac death, re-infarction, heart failure related to ISR. In without ISR, minimal...
Abstract Background Few studies explored the effect of combination glucose sodium-cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on incidence cardiovascular events in patients with type 2 diabetes (T2D) acute myocardial infarction (AMI). Methods We recruited T2D AMI undergoing percutaneous coronary intervention, treated either SGLT-2i or GLP-1RA for at least 3 months before hospitalization. Subjects HbA1c < 7% admission were considered good...
Resistin, a novel adipokine, is elevated in patients with type 2 diabetes and may play role the vascular complications of this disorder. One recent study has shown that resistin proinflammatory effect on endothelial cells. However, there no information whether could also affect smooth muscle cells (SMCs). Thus, purpose was to assess induce SMC proliferation mechanisms whereby signals SMCs.Human aortic (HASMCs) were stimulated increasing concentrations for 48 hours. Cell induced by...
Accurate echocardiographic parameters to predict maintenance of sinus rhythm in patients with atrial fibrillation (AF) are poorly defined. This study was conducted assess the myocardial properties during AF through velocity, strain rate, and compare their prognostic value maintaining lone standard transthoracic (TTE) transesophageal echocardiography (TEE).Sixty-five consecutive for < or =3 months underwent TTE, TEE, velocity rate imaging examinations before successful external cardioversion....
Context: Obesity and iron deficiency are two of the most common nutritional disorders worldwide. Several studies found higher rates in obese than normal-weight children. Hepcidin represents main inhibitor intestinal absorption, its expression is increased adipose tissue patients. Leptin able, vitro, to raise hepcidin expression. Objectives: Aims this work were 1) assess association between poor status obesity, 2) investigate whether homeostasis children may be modulated by serum variations,...
Relationship between obesity and cardiovascular (CV) disease depends not only on the amount of body fat, but also its distribution. For example, individuals with increased fat accumulation in abdominal region have atherogenic lipid profiles are at CV risk. The loss elasticity medium large arteries is an early manifestation atherosclerosis. aim this study was to evaluate whether echocardiographic epicardial adipose tissue, index cardiac adiposity, related carotid stiffness intima-media...
OBJECTIVE To evaluate the effect of metformin therapy on coronary endothelial function and major adverse cardiac events (MACE) in patients with prediabetes stable angina nonobstructive stenosis (NOCS). RESEARCH DESIGN AND METHODS Metformin may be needed to reduce heart disease risk prediabetes. A total 258 propensity score–matched (PSM) undergoing angiography were enrolled study. Data from 86 PSM subjects normoglycemia (NG), (pre-DM), treated (pre-DM metformin) analyzed. During angiography,...