Filippo Angelini
A5090649823- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Pain Management and Treatment
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
- Cardiac, Anesthesia and Surgical Outcomes
- Extracellular vesicles in disease
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and Diving-Related Complications
- Cardiovascular Issues in Pregnancy
- Nuclear Structure and Function
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2018-2025
University of Turin
2018-2025
IRCCS Istituto Auxologico Italiano
2023-2024
Epatocentro Ticino
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
Policlinico San Matteo Fondazione
2023-2024
University of Padua
2023-2024
University of Pavia
2023-2024
Ospedale San Giovanni Bosco
2023-2024
Fatebenefratelli Hospital
2024
fully explained by Covid-19 cases alone. 5This observation and data from our study raise the question of wheth-
Abstract Aims To evaluate the impact of COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results We conducted a multicentre, observational, nationwide survey collect data for acute myocardial infarction (AMI) at CCUs throughout 1 week period during outbreak, compared with equivalent in 2019. observed 48.4% reduction AMI 2019 (P < 0.001). The was significant both ST-segment elevation [STEMI; 26.5%, 95% confidence interval (CI) 21.7–32.3; P =...
Abstract Background and Aims An electrical storm (ES) is a clinical emergency with paucity of established treatment options. Despite initial encouraging reports about the safety effectiveness percutaneous stellate ganglion block (PSGB), many questions remained unsettled evidence from prospective multicentre study was still lacking. For these purposes, STAR designed. Methods This observational enrolling patients suffering an ES refractory to standard 1 July 2017 30 June 2023. The primary...
Abstract Background and Aims Risk stratification for mitral valve transcatheter edge-to-edge repair (M-TEER) is paramount in the decision-making process to appropriately select patients with severe secondary regurgitation (SMR). This study sought develop validate an artificial intelligence-derived risk score (EuroSMR score) predict 1-year outcomes (survival or survival + clinical improvement) SMR undergoing M-TEER. Methods An was developed from EuroSMR cohort (4172 428 treated M-TEER...
The cardiac autonomic nervous system (CANS) plays a pivotal role in homeostasis as well pathology. first level of control, the intrinsic (ICNS), is located within epicardial fat pads and physically organized ganglionated plexi (GPs). ICNS does not only contain parasympathetic efferent neurons, long believed, but also afferent neurons local circuit neurons. Thanks to its high degree connectivity, combined with neuronal plasticity memory capacity, allows for beat-to-beat control all functions...
Background and Purpose- Despite treatment with oral anticoagulants, patients nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in AF were to identify the pathogenesis risk factors for events occurring during non-vitamin K antagonist anticoagulants (NOACs) therapy stroke prevention. Methods- Cases consecutive who had acute NOAC treatment. Controls did not have NOACs Results- Overall, 713 cases (641 strokes 72 transient...
Background Little is known about the impact of transcatheter mitral valve edge-to-edge repair on changes in left ventricular ejection fraction (LVEF) and effect an acute reduction LVEF prognosis. We aimed to assess after for both primary secondary regurgitation (PMR SMR, respectively), identify rates predictors reduction, estimate its Methods Results In this international multicenter registry, patients with PMR SMR undergoing were included. assessed (LVEFR), defined as relative decrease >15%...
Patients presenting with cardiogenic shock (CS) are at risk of developing mixed (MS), characterized by distributive-inflammatory phenotype. However, no objective definition exists for this clinical entity.
The relevance of extracellular vesicles (EV) as mediators cardiac damage or recovery upon Ischemia Reperfusion Injury (IRI) and Remote Ischemic PreConditioning (RIPC) is controversial. This study aimed to investigate whether serum-derived EV, recovered from patients with Acute Coronary Syndrome (ACS) subjected the RIPC sham procedures, may be a suitable therapeutic approach prevent IRI during Percutaneous-Coronary-Intervention (PCI). A double-blind, randomized, sham-controlled (NCT02195726)...
Abstract Aims Haemodynamic assessment can be determinant in phenotyping cardiogenic shock (CS) and guiding patient management. Aim of this study was to evaluate the correlation between echocardiographic invasive haemodynamics acute decompensated heart failure-related CS (ADHF-CS). Methods results All consecutive ADHF-CS patients (SCAI stage ≥B) undergoing right catheterization (RHC) 2020 2022 were prospectively enrolled. Patients underwent echocardiography 30 min before RHC. The evaluated...
Abstract Aims Electrical storm (ES) is a life-threatening condition requiring rapid management. Percutaneous stellate ganglion block (PSGB) proved to be safe and effective on top of standard therapy, but no data are available about its early use. Methods results We considered all patients enrolled from 1 July 2017 30 April 2024 in the STAR registry (STellate for Arrhythmic stoRm), multicentre, international, observational, prospective registry. aimed assess effectiveness first PSGB only....
Abstract Brugada syndrome is an inherited channelopathy with increased risk of sudden cardiac death (SCD) due to ventricular arrhythmias (VA) and incidence supraventricular arrhythmias, as compared the general population. For prevention SCD, guidelines recommend implantable cardioverter-defibrillator (ICD); however, ICD does not prevent VA. In this article, we provide a brief review literature on pharmacological therapy, mainly focusing quinidine treatment. The efficacy therapy in VA has...
Electrical storm (ES) is a life-threatening condition characterized by at least three separate episodes of ventricular arrhythmias (VAs) over 24 h, each requiring therapeutic intervention, including implantable cardioverter defibrillator (ICD) therapies. Patients with ICDs in secondary prevention are higher risk ES and the most common presentation that scar-related monomorphic VAs. represents major unfavourable prognostic marker history patients structural heart disease, an associated two-...
Cardiac laminopathies encompass a wide range of diseases caused by defects in nuclear envelope proteins, including cardiomyopathy, atrial and ventricular arrhythmias conduction system abnormalities. Two genes, namely LMNA EMD, are typically associated with these disorders part the routine genetic panel performed affected patients. Yet, there other markedly fewer known nesprins, encoded SYNE that play pivotal role connecting to cytoskeletal elements. So far, gene variants have been described...
Abstract Background Severe functional mitral regurgitation (FMR) may benefit from Transcathter Edge to Egde Repair (TEER), but selection of patients remains be optimised. Objectives The aim this study was use Machine-Learning (ML) approaches uncover concealed connections between clinical, echocardiographic, and hemodynamic data associated with patients’ outcomes. Methods Consecutive undergoing TEER 2009 2020 were included in the MITRA-AI registry. primary endpoint a composite cardiovascular...