Elisa Giorli
A5082697637- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Amyotrophic Lateral Sclerosis Research
- Migraine and Headache Studies
- Neurogenetic and Muscular Disorders Research
- Stroke Rehabilitation and Recovery
- Peripheral Neuropathies and Disorders
- Neurological Complications and Syndromes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and genetic disorders
- Functional Brain Connectivity Studies
- Hereditary Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Neurosurgical Procedures and Complications
- Cardiac Arrhythmias and Treatments
- Visual perception and processing mechanisms
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Neurological disorders and treatments
- Restless Legs Syndrome Research
CTO Andrea Alesini
2016-2025
Azienda Ospedaliera Sant'Andrea
2016-2024
Liechtenstein Institute
2023
Cognitive Neuroimaging Lab
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
St. Anne's University Hospital Brno
2017
University Hospital of Alexandroupolis
2017
Democritus University of Thrace
2017
University General Hospital Attikon
2017
Background The optimal timing to administer non–vitamin K oral anticoagulants ( NOAC s) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated the rates of early recurrence major bleeding (within 90 days) their who received s for secondary prevention. Methods Results Recurrence was defined as composite stroke, transient attack, symptomatic systemic embolism, cerebral extracranial bleeding. For analysis, 1127 were...
Background and Purpose- Despite treatment with oral anticoagulants, patients nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in AF were to identify the pathogenesis risk factors for events occurring during non-vitamin K antagonist anticoagulants (NOACs) therapy stroke prevention. Methods- Cases consecutive who had acute NOAC treatment. Controls did not have NOACs Results- Overall, 713 cases (641 strokes 72 transient...
In patients with atrial fibrillation who suffered an ischemic stroke while on treatment nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent events major bleedings remain uncertain.This prospective multicenter observational study aimed to estimate the bleeding their in follow-up consecutive acute cerebrovascular event anticoagulant treatment. Afterwards, we compared estimated risks between whom therapy was changed those continued original treatment.After a mean...
Background In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents recurrence but the risk of hemorrhagic transformation ( HT ). The aims this study were to evaluate in consecutive fibrillation (1) incidence HT, (2) time initiation , (3) association recurrences, (4) clinical outcome at 90 days. Methods Results was diagnosed by a second brain computed tomographic scan performed 24 72 hours after onset. recurrences as well mortality or disability...
<h3>Importance</h3> Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association the 2 disorders is still unconfirmed. This lack of definitive conclusion might implications in understanding pathogenesis both conditions complex relationship ischemic stroke (IS). <h3>Objective</h3> To investigate whether history its subtypes associated with occurrence CEAD. <h3>Design, Setting, Participants</h3> A prospective cohort study...
<h3>Objective</h3> To define the current treatment practice of Guillain-Barré syndrome (GBS). <h3>Methods</h3> The study was based on prospective observational data from first 1,300 patients included in International GBS Outcome Study. We described general, and for (1) severe forms (unable to walk independently), (2) no recovery after initial treatment, (3) treatment-related fluctuations, (4) mild (able (5) variant including Miller Fisher syndrome, taking patient characteristics hospital...
Background and Purpose: Observational studies have suggested a link between fibromuscular dysplasia spontaneous cervical artery dissection (sCeAD). However, whether patients with coexistence of the two conditions distinctive clinical characteristics has not been extensively investigated. Methods: In cohort consecutive first-ever sCeAD, enrolled in setting multicenter IPSYS CeAD study (Italian Project on Stroke Young Adults Cervical Artery Dissection) January 2000 June 2019, we compared...
Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as risk factor both ischemic bleeding complications with AF stroke. Based on these premises, we conducted sub-analysis the RAF RAF-NOAC studies to evaluate acute AF. Materials methods: We combined patient from studies, prospective across Stroke Units Europe, United States, Asia...
: The spatial and temporal distribution of intracerebral hemorrhage (ICH) recurrence are largely unknown. To assess timing location recurrent ICH events in relation to the index event (adjacent [adjICH] vs remote [remICH]). This cohort study was a pooled analysis individual studies from 2002 2021 among hospital-based European cohorts. Patients with 2 or more clinically distinguishable (≥1 recurrent) small vessel disease-related were included. Data performed December 2023 2024. underlying...
This study was designed to derive and validate a score predict early ischemic events major bleedings after an acute stroke in patients with atrial fibrillation.The derivation cohort consisted of 854 fibrillation included prospective series between January 2012 March 2014. Older age (hazard ratio 1.06 for each additional year; 95% confidence interval, 1.00-1.11) severe enlargement ratio, 2.05; 1.08-2.87) were predictors outcome (stroke, transient attack, systemic embolism) at 90 days from...
Background and Purpose— Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of higher incidence intracerebral bleeding. However, this practice is common in clinical settings. This observational study aimed compare (1) the profiles receiving not bridging therapy, (2) overall group outcomes, (3) outcomes according type anticoagulant prescribed. Methods— We analyzed data from prospective RAF RAF-NOACs studies....
Objective Epidemiological data to characterize the individual risk profile of patients with spontaneous cervical artery dissection (sCeAD) are rather inconsistent. Methods and Results In setting Italian Project on Stroke in Young Adults Cervical Artery Dissection (IPSYS CeAD), we compared characteristics 1,468 sCeAD (mean age = 47.3 ± 11.3 years, men 56.7%) prospectively recruited at 39 centers those 2 control groups, composed (1) whose ischemic stroke was caused by mechanisms other than...
Abstract Whether to resume antithrombotic treatment after oral anticoagulant–related intracerebral haemorrhage (OAC-ICH) is debatable. In this study, we aimed at investigating long-term outcome associated with OAC resumption warfarin-related ICH, in comparison secondary prevention strategies platelet inhibitors or discontinuation. Participants were patients who sustained an incident ICH during warfarin (2002–2014) included the Multicenter Study on Cerebral Hemorrhage Italy. Primary end-point...
<h3>Objective</h3> To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to pathogenic mechanisms underlying cerebral bleeding. <h3>Methods</h3> We performed case-control analysis, comparing cohort consecutive white patients with ICH aged 55 years older group age- sex-matched stroke-free controls, enrolled in setting Multicenter Study on Cerebral Haemorrhage Italy (MUCH-Italy) between 2002 2014. Participants were...
Introduction: Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of recurrence despite oral anticoagulation therapy. Patients cardiovascular comorbidities may take both antiplatelet and therapy (OAC/AP). Our study aims to evaluate the safety efficacy OAC/AP as secondary prevention in people AF ischaemic stroke. methods: We performed a post-hoc analysis pooled individual data from multicenter prospective cohort studies compared outcomes on DOAC/VKA alone (OAC cohort)....
The identification of patients surviving an acute intracerebral hemorrhage who are at a long-term risk arterial thrombosis is poorly defined, crucial issue for clinicians.
Introduction: It is unclear which patients with non-traumatic (spontaneous) intracerebral haemorrhage (ICH) are at risk of developing acute symptomatic seizures (provoked occurring within the first week after stroke onset; early seizures, ES) and whether ES predispose to occurrence remote (unprovoked more than 1 stroke; post-stroke epilepsy, PSE) long-term mortality. Patients Methods: In setting Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) we examined they predict PSE...
Cerebral vasomotor reserve (VMR) is the capability of cerebral arterioles to change their diameter in response various stimuli, such hypercapnia. Changes VMR due transcranial direct current stimulation (tDCS) have been poorly studied.Twenty-five healthy subjects underwent anodal/cathodal and sham tDCS on right primary motor area. Before after tDCS, we assessed by Transcranial Color-Coded Sonography (TCCS) calculating trought Breath Holding Index (BHI) Heart Rate Variability (HRV), particular...
Guillain‐Barré syndrome (GBS) is an acute immune‐mediated polyradiculoneuropathy with a worldwide incidence of 0.81‐1.89 per 100 000 person‐years. In Europe and North America only 5% patients GBS have axonal subtypes, which in South Asia account for 30%‐47% cases. The aim our study to assess the annual clinical features La Spezia area Italy. A retrospective (from 1 January 2003 31 December 2011) followed by prospective 2012 2015) analysis was carried out on admitted hospital who fulfilled...
Background— We sought to compare the benefit of percutaneous closure that medical therapy alone for secondary prevention embolism in patients with patent foramen ovale (PFO) and otherwise unexplained ischemic stroke, a propensity scored study. Methods Results— Between 2000 2012, we selected consecutive first-ever stroke aged 18 45 years PFO no other cause brain ischemia, as part IPSYS registry (Italian Project on Stroke Young Adults), who underwent either or comparative analysis. Primary end...
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Objective To explore the impact of antithrombotic therapy discontinuation in postacute phase cervical artery dissection (CeAD) on mid-term outcome these patients. Methods In a cohort consecutive patients with first-ever CeAD, enrolled setting multicentre Italian Project Stroke Young Adults Cervical Artery Dissection, we compared (beyond 6 months since index CeAD) outcomes between who discontinued and continued taking agents during follow-up. Primary was composite ischaemic stroke transient...
Introduction: Patients with ischemic stroke (IS) and atrial fibrillation (AF) face a higher risk of recurrent vascular events. This study evaluates the impact atherosclerotic disease burden across different territories on events in patients recent AF within 90 days. Methods: We included IS from International RAF network prospective 90-day follow-up. Atherosclerotic was identified by at least one following: Symptomatic heart disease, symptomatic peripheral artery internal carotid stenosis...