A5088823694- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- Migraine and Headache Studies
- Neurotransmitter Receptor Influence on Behavior
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Multiple Sclerosis Research Studies
- Neural dynamics and brain function
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Memory and Neural Mechanisms
- Pharmacological Effects and Toxicity Studies
- Neuroscience of respiration and sleep
- Trigeminal Neuralgia and Treatments
- Long-Term Effects of COVID-19
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Dementia and Cognitive Impairment Research
Università Cattolica del Sacro Cuore
2020-2025
Agostino Gemelli University Polyclinic
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Clínica Santa María
2024
University of Catania
2023
University of Milan
2021-2023
University of Szeged
2023
University Hospital of Bern
2023
University of Bern
2023
Istituti Ospitalieri di Cremona
2023
The effect of tetanic activation corticostriatal glutamatergic fibers was studied in striatal slices by utilizing extracellular and intracellular recording techniques. Tetanic stimulation produced a long- term synaptic depression (LTD) (> 2 h) both extracellularly recorded field potentials intracellularly EPSPs. LTD not coupled with changes intrinsic membrane properties the neurons. In some neurons, repetitive cortical short-term posttetanic potentiation (1–3 min). Subthreshold...
We have studied the effects of tetanic stimulation corticostriatal pathway on amplitude striatal excitatory synaptic potentials. Recordings were obtained from a slice preparation by utilizing both extracellular and intracellular techniques. Under control condition (1.2 mM external Mg2+), postsynaptic potentials (EPSPs) evoked cortical reversibly blocked 10 microM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an antagonist dl-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)...
ABSTRACT To assess the discriminating power of multiple cerebrospinal fluid (CSF) biomarkers for Parkinson's disease (PD), we measured several proteins playing an important role in pathogenesis. The activities β‐glucocerebrosidase and other lysosomal enzymes, together with total oligomeric α‐synuclein, phosphorylated tau, were thus assessed CSF 71 PD patients compared to 45 neurological controls. Activities β‐glucocerebrosidase, β‐mannosidase, β‐hexosaminidase, β‐galactosidase established...
Neuroinflammation is one of the hallmarks Parkinson's disease (PD) and may contribute to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation with failure resolve early inflammation, a process operated by specialized pro-resolving mediators, including resolvins. However, effects stimulating resolution in PD - modulate progression still remain unexplored. Here we show that rats overexpressing human α-synuclein (Syn) display altered DA properties, reduced...