A5053298462- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Receptor Mechanisms and Signaling
- Nuclear Receptors and Signaling
- Memory and Neural Mechanisms
- Nerve injury and regeneration
- Adenosine and Purinergic Signaling
- Multiple Sclerosis Research Studies
- Mitochondrial Function and Pathology
- Neural dynamics and brain function
- Autism Spectrum Disorder Research
- Epilepsy research and treatment
- Prenatal Substance Exposure Effects
- Botulinum Toxin and Related Neurological Disorders
- Ion channel regulation and function
- Cannabis and Cannabinoid Research
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
Agostino Gemelli University Polyclinic
2022-2025
San Raffaele University of Rome
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2021
Fondazione Santa Lucia
2012-2021
Vita-Salute San Raffaele University
2021
University of Perugia
2006-2020
European Brain Research Institute
2007
Azienda Ospedaliera di Perugia
2006
University of Ferrara
2003
University of Bari Aldo Moro
2003
Neuroinflammation is one of the hallmarks Parkinson's disease (PD) and may contribute to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation with failure resolve early inflammation, a process operated by specialized pro-resolving mediators, including resolvins. However, effects stimulating resolution in PD - modulate progression still remain unexplored. Here we show that rats overexpressing human α-synuclein (Syn) display altered DA properties, reduced...
Abnormal function of NMDA receptor has been suggested to be correlated with the pathogenesis Parkinson’s disease (PD) as well development l -3,4-dihydroxyphenylalanine ( -DOPA)-induced dyskinesia. Here we show that NR2 subunits display specific alterations their subcellular distribution in striata from unilateral 6-hydroxydopamine-lesioned, -DOPA-treated dyskinetic, and nondyskinetic rats. Dyskinetic animals have significantly higher levels NR2A subunit postsynaptic compartment than all...
To investigate the possible long-term consequences of gestational exposure to cannabinoids on cognitive functions, pregnant rats were administered with CB1 receptor agonist WIN 55,212-2 (WIN), at a dose (0.5 mg/kg) that causes neither malformations nor overt signs toxicity. Prenatal induced disruption memory retention in 40- and 80-day-old offspring subjected passive avoidance task. A hyperactive behavior ages 12 40 days was also found. The impairment caused by correlated alterations...
A correct interplay between dopamine (DA) and glutamate is essential for corticostriatal synaptic plasticity motor activity. In an experimental model of Parkinson's disease (PD) obtained in rats, the complete depletion striatal DA, mimicking advanced stages disease, results loss both forms plasticity: long-term potentiation (LTP) depression (LTD). However, early PD are characterized by incomplete reduction DA levels. The mechanism which this level affects glutamatergic synapses unknown. Here...
A(2A) adenosine receptor antagonists are currently under investigation as potential therapeutic agents for Parkinson's disease (PD). However, the molecular mechanisms underlying this effect is still unclear. A functional antagonism exists between and D(2) dopamine (DA) receptors that coexpressed in striatal medium spiny neurons (MSNs) of indirect pathway. Since interaction could also occur other neuronal subtypes, we have analyzed pharmacological modulation relationship murine MSNs direct...
Although patients with Parkinson's disease show impairments in cognitive performance even at the early stage of disease, synaptic mechanisms underlying impairment this pathology are unknown.Hippocampal long-term potentiation represents major experimental model for changes learning and memory is controlled by endogenous dopamine.We found that hippocampal altered both a neurotoxic transgenic plastic alteration associated an impaired dopaminergic transmission decrease NR2A/NR2B subunit ratio...
The aim of the present study was to evaluate role nitric oxide/cyclic guanosine monophosphate pathway in corticostriatal long-term depression induction a model levodopa-induced dyskinesia experimental parkinsonism. Moreover, we have also analysed possibility targeting striatal phosphodiesterases reduce dyskinesia. To synaptic plasticity sham-operated rats and 6-hydroxydopamine lesioned animals chronically treated with therapeutic doses levodopa, recordings from spiny neurons were taken using...
Parkinson's disease is a progressive neurodegenerative disorder characterized by altered striatal dopaminergic signalling that leads to motor and cognitive deficits. also abnormal presence of soluble toxic forms α-synuclein that, when clustered into Lewy bodies, represents one the pathological hallmarks disease. However, oligomers might directly affect synaptic transmission plasticity in models. Accordingly, combining electrophysiological, optogenetic, immunofluorescence, molecular...
Abstract Misfolding and aggregation of α-synuclein are specific features Parkinson’s disease other neurodegenerative diseases defined as synucleinopathies. progression has been correlated with the formation extracellular release aggregates, well their spread from neuron to neuron. Therapeutic interventions in initial stages require a clear understanding mechanisms by which disrupts physiological synaptic plastic activity basal ganglia. For this reason, we identified two early time points...
Intensive physical activity improves motor functions in patients with Parkinson's disease (PD) at early stages. However, the mechanisms underlying beneficial effects of exercise on PD-associated neuronal alterations have not been fully clarified yet. Here, we tested hypothesis that an intensive treadmill training program rescues striatal plasticity and cognitive deficits rats receiving intrastriatal injection alpha-synuclein (α-syn) preformed fibrils. Improved control visuospatial learning...