A5079771346- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Neurological and metabolic disorders
- Nuclear Receptors and Signaling
- Functional Brain Connectivity Studies
- Restless Legs Syndrome Research
- Metabolomics and Mass Spectrometry Studies
- Artificial Intelligence in Healthcare and Education
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Multiple Sclerosis Research Studies
- Computational Drug Discovery Methods
- Sleep and related disorders
- Neurological Disease Mechanisms and Treatments
- Cerebral Venous Sinus Thrombosis
- Sleep and Wakefulness Research
- Alcoholism and Thiamine Deficiency
- Ethics in Clinical Research
Fondazione Santa Lucia
2016-2025
European Brain Research Institute
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
University of Rome Tor Vergata
2009-2023
Policlinico Tor Vergata
2011-2020
European University of Rome
2011
Institute of Molecular Biology and Pathology
2009
Istituto di Sessuologia Clinica
1983
<h3>Importance</h3> Nocturnal sleep disruption develops in Alzheimer disease (AD) owing to the derangement of sleep-wake cycle regulation pathways. Orexin contributes by increasing arousal levels and maintaining wakefulness. <h3>Objectives</h3> To study cerebrospinal fluid orexin patients with AD, evaluate relationship degree dementia AD biomarkers (tau proteins β-amyloid 1-42), analyze potentially related architecture changes measured polysomnography. <h3>Design, Setting, Participants</h3>...
Neuroinflammation is one of the hallmarks Parkinson's disease (PD) and may contribute to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation with failure resolve early inflammation, a process operated by specialized pro-resolving mediators, including resolvins. However, effects stimulating resolution in PD - modulate progression still remain unexplored. Here we show that rats overexpressing human α-synuclein (Syn) display altered DA properties, reduced...
In the gut of patients with Crohn's disease (CD), high Smad7 blocks immune-suppressive activity transforming growth factor (TGF)-β1, thereby contributing to amplify inflammatory signals. vivo in mice, knockdown a antisense oligonucleotide (GED0301) attenuates experimental colitis. Here, we provide results phase 1 clinical, open-label, dose-escalation study GED0301 active, steroid-dependent/resistant CD, aimed at assessing safety and tolerability drug. Patients were allocated three treatment...
Background: Chronic inflammation leads to gray matter damage in progressive multiple sclerosis (MS), but the mechanism linking and neurodegeneration is unclear. Objective: The objective of this paper investigate synaptic inflammatory forms MS. Methods: Cytokine neurofilament-light were determined cerebrospinal fluid (CSF) MS patients. In vitro electrophysiology cell swelling experiments performed measure effects cytokines CSF patients on transmission neuronal integrity. Results: Tumor...
Abstract Background and purpose Parkinson disease (PD) presents relevant sex‐related differences in epidemiology, pathophysiology, clinical features, with males being more vulnerable to the disease. Sex hormones might have a role, as experimental models suggest; however, human‐based evidence is scarce. Here, we integrated multimodal biomarkers investigate relationships between circulating sex clinical–pathological features male PD patients. Methods A cohort of 63 patients underwent...
Background: Alzheimer’s disease (AD) is the most common form of dementia. It mainly characterized by a progressive deterioration cognition, but sleep-wake cycle disturbances frequently occur. Irregular cycle, insomnia, and daytime napping usually occur in patients with AD course disease. Objective: The aim present study was to verify mild moderate compared controls, evaluate relationship between impairment neuropsychological testing, CSF biomarkers, orexin concentrations. Methods: Mild were...
Background:Although motor disturbances parallel the course of dementia, worsening both quality life and social costs, pathogenesis remains still unclear. Objective:Through combination cerebrospinal fluid (CSF) biomarkers assessment transcranial magnetic stimulation (TMS) protocols , here we provided a cross-sectional study to understand pathogenic mechanisms Alzheimer's disease (AD)-related early disturbances. Methods:The phenotype, as defined with Unified Parkinson's Disease Rating Scale...
Emerging evidence indicates that apolipoprotein E (APOE) genotype may influence Parkinson's disease (PD) course, although clinical and neurochemical correlates have not been completely established. This study aimed to determine the associations of APOE genotypes (ε4 vs. non-ε4) with cerebrospinal fluid (CSF) neurodegeneration biomarkers parameters in early-stage PD patients. One hundred seventy-five patients 89 non-neurodegenerative controls grouped APOE-ε4 carriers (28 PD; 12 controls)...
Background: Inflammation triggers secondary neurodegeneration in multiple sclerosis (MS). Objectives: It is unclear whether classical anti-inflammatory cytokines have the potential to interfere with synaptic transmission and neuronal survival MS. Methods: Correlation analyses between cerebrospinal fluid (CSF) contents of molecular, imaging, clinical, neurophysiological measures alterations were performed. Results: Our data suggest that interleukin-13 (IL-13) plays a neuroprotective role MS...
Idiopathic normal pressure hydrocephalus (iNPH) can be misdiagnosed with other neurodegenerative diseases, especially in the early disease stages. Considering opportunity of shunt surgery, iNPH should diagnosed accuracy. Here, we evaluate utility CSF biomarkers and their relationship clinical features diagnosis iNPH.We performed a multivariate analysis levels Aβ42, t-tau, p-tau collected from four groups patients: 14 iNPH, progressive supranuclear palsy (PSP), Alzheimer's (AD), controls...
Accumulation and aggregation of misfolded alpha-synuclein is believed to be a cause Parkinson's disease (PD). Phosphorylation at S129 known associated with the pathological misfolding process, but efforts investigate relevance this post-translational modification for pathology have been frustrated by difficulties in detecting quantifying it relevant samples. We report novel, ultrasensitive immunoassays based on single-molecule counting technology, useful its phosphorylated form clinical...