A5018671665- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Parkinson's Disease Mechanisms and Treatments
- PARP inhibition in cancer therapy
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Glycogen Storage Diseases and Myoclonus
- RNA regulation and disease
- Viral Infections and Outbreaks Research
- Inflammasome and immune disorders
- interferon and immune responses
- Genetic Neurodegenerative Diseases
- Genomics, phytochemicals, and oxidative stress
- Genomics and Rare Diseases
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Genetics and Neurodevelopmental Disorders
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- Protein Tyrosine Phosphatases
- Moyamoya disease diagnosis and treatment
- Autoimmune Neurological Disorders and Treatments
- Cerebrovascular and genetic disorders
Bambino Gesù Children's Hospital
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2024-2025
University of Rome Tor Vergata
2017-2024
Policlinico Tor Vergata
2020
With the aim to individuate alleles that may reflect a higher susceptibility disease, in present study we analyzed HLA allele frequency distribution group of 99 Italian patients affected by severe or extremely form COVID-19. After application Bonferroni's correction for multiple tests, significant association was found HLA-DRB1*15:01, -DQB1*06:02 and -B*27:07, after comparing results reference 1017 individuals, previously typed our laboratory. The increased frequencies observed contribute...
Effective disease-modifying treatments are an urgent need for Parkinson's disease (PD). A putative successful strategy is to counteract oxidative stress, not only with synthetic compounds, but also natural agents or dietary choices. Vitamin E, in particular, a powerful antioxidant, commonly found vegetables and other components of the diet. In this work, we performed questionnaire based case-control study on 100 PD patients healthy controls. The analysis showed that higher intake E was...
Abstract Background Coronaviruses (CoV) are a large family of viruses that common in humans and many animal species. Animal coronaviruses rarely infect with the exceptions Middle East respiratory syndrome ( MERS-CoV ), severe acute corona virus (SARS-CoV), now SARS-CoV-2, which is cause ongoing pandemic coronavirus disease 2019 (COVID-19). Several studies suggested genetic variants ACE2 gene may influence host susceptibility or resistance to SARS-CoV-2 infection according functional role...
It has been a little over one year, since SARS-CoV-2 appeared in the human population through probable zoonotic origin. However, despite discovery of animal coronaviruses related to SARS-CoV-2, evolutionary origins this virus are elusive1. There debate about origin with scrutiny and investigations2. Though World Health Organization (WHO) set up panel scientists investigate initial response COVID-19, no significant results have emerged yet3. is important define elaborate protocols action4,...
Abstract SARS-CoV-2 is responsible for the ongoing world-wide pandemic which has already taken more than two million lives. Effective treatments are urgently needed. The enzymatic activity of HECT-E3 ligase family members been implicated in cell egression phase deadly RNA viruses such as Ebola through direct interaction its VP40 Protein. Here we report that NEDD4 and WWP1 interact with ubiquitylate Spike protein. Furthermore, find HECT overexpressed primary samples derived from COVID-19...
Abstract Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) is the novel coronavirus responsible for worldwide disease (COVID‐19). We previously observed that Angiotensin‐converting enzyme 2 (ACE2) and Dipeptidyl peptidase‐4 (DPP4) are significantly overexpressed in naso‐oropharyngeal swabs (NPS) of COVID‐19 patients, suggesting their putative functional role progression. ACE2 DPP4 overexpression patients may be associated to epigenetic mechanism, such as miRNA differential...
We collect the nasopharyngeal and oropharyngeal swabs of 63 subjects with severe symptoms or contacts COVID-19 confirmed cases to perform a pilot-study aimed verify "in situ" expression SARS-CoV-2 host invasion genes (ACE2, TMPRSS2, PCSK3, EMILIN1, EMILIN2, MMRN1, MMRN2, DPP4). ACE2 (FC = +1.88, p ≤ 0.05) DPP4 +3, < 0.01) showed significant overexpression in patients. levels had good performance (AUC 0.75; 0.001) distinguishing patients from negative subjects. Interestingly, we found...
Background: Childhood-onset progressive ataxias are rare neurodegenerative disorders characterized by cerebellar signs, sometimes associated with other neurological or extra-neurological features. The autosomal dominant forms, known as spinocerebellar (SCAs), linked to trinucleotide (i.e., CAG) repeat disorders, ultra-rare in children. We describe three patients from two unrelated families affected ataxia type 2 (SCA2) and present a literature review of pediatric cases. Methods: patients’...
Background:Synaptopathy is critical in pathophysiology of Parkinson's disease (PD). Cerebrospinal fluid (CSF) levels neurogranin (NG) and amyloid-β42 (Aβ42) are considered markers synaptic dysfunction neurodegenerative diseases. Objective:To evaluate the CSF synaptopathy-related biomarkers , especially novel Aβ42/NG ratio, PD, establishing possible associations with cognitive level other clinical parameters. Methods:Levels NG, Aβ42, amyloid-β40, total phosphorylated tau, ratio were measured...